Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD t...

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Autores: Galluzzi, L. (Lorenzo)|||/items/a8408d1f-8344-4d64-82a7-a8775587ef8d, Vitale, I. (Ilio)|||/items/9347592d-2429-40b2-bd8f-3767db69b71f, Warren, S. (Sarah)|||/items/9e123407-bbae-4935-b8dd-bf7c268e8019, Adjemian, S. (Sandy)|||/items/c3dab013-a0b6-4b18-a9c9-0cfdf4b3c046, Agostinis, P. (Patrizia)|||/items/213b267b-bfda-4518-9719-8a92eab98764, Buqué-Martinez, A. (Aitziber)|||/items/72a4d0d3-9113-4b9e-b28d-6b0906cb4e46, Chan, T.A. (Timothy A.)|||/items/ec3f7943-9bab-464d-9c6c-0ca9f9320468, Coukos, G. (George)|||/items/efed5fa1-2d63-4857-b88b-db87c76ddb13, Demaria, S. (Sandra)|||/items/986e51ce-321e-49b4-ad13-6221dcf18730, Deutsch, É. (Éric)|||/items/ef1c66e9-c315-436e-9ba7-d7bd479e903a, Draganov, D. (Dobrin)|||/items/356e480d-5a92-4eb3-9a91-272e08725048, Edelson, R.L. (Richard L.)|||/items/aa9c73c3-829c-4514-b2af-f0f7510125eb, Formenti, S.C. (Silvia C.)|||/items/74a16880-1965-41de-aa88-d7cae7339d0d, Fucíková, J. (Jitka)|||/items/f2113303-ffc9-4f30-96a5-732bc7400535, Gabriele, L. (Lucia)|||/items/744dbe2d-d5c3-4105-9ae2-c0eef7cbcda4, Gaipl, U.S. (Udo S.)|||/items/5bc3d4bf-f9d7-48f8-96c9-5df5ab20123d, Gameiro, S.R. (Sofa R.)|||/items/c2464cf7-0212-463c-bcdc-8d17157a5cfb, Garg, A. (Abhishek)|||/items/4ec306cb-0a8a-4465-86c9-65493487177f, Golden, E. (Encouse)|||/items/bb19f522-d9d8-42fc-925d-8da220ce3794, Han, J. (Jian)|||/items/e4d4d7f8-1252-4cf1-9d51-cda90903bf94, Harrington, K. (K.)|||/items/49c3b81c-f669-4160-831b-6855088e8025, Hemmink, A. (Akseli)|||/items/7ab68488-1bc1-4dcf-8d56-011d73c29ac6, Hodge, J.W. (James W.)|||/items/9a01618a-96c5-4c29-8774-bb165090fb4f, Sakib-Hossain, D. (Dewan)|||/items/2926a608-6893-4fcc-93b9-162b9abe5461, Illidge, T. (Tim)|||/items/dd339f30-e7e4-4c31-a491-49d4890f9afe, Karin, M. (Michael)|||/items/232b1790-447c-43d3-8f1b-2a2bd649a76b, Kaufman, H.L. (Howard L.)|||/items/4870639e-d97e-4f4a-884c-64be7128c5f4, Kepp, O. (Oliver)|||/items/9b6da306-5f4f-4516-9c04-01d5fd19b583, Kroemer, G. (Guido)|||/items/ae5c18f3-0594-4a44-b71d-a367305f464f, Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c, Loi, S. (Sherene)|||/items/13f77762-2435-4c03-915b-732b96ede0b4, Lotze, M.T. (Michael T.)|||/items/b8069a66-92e6-4407-9e36-5f73338612b5, Manic, G. (Gwenola)|||/items/2feb01d3-bd45-4ee4-ad83-f2fd2b7cb168, Merghoub, T. (Taha)|||/items/eac00cc5-f2c8-4c5b-9b1d-8bb125dcd6f9, Melcher, A. (Alan)|||/items/3fa02d4b-997e-4390-87b6-d4de93c57e24, Mossman, K.L. (Karen L.)|||/items/06b61333-08e2-4d4e-a76b-78f25f6e9723, Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1, Rekdal, O. (Oystein)|||/items/c348d531-475e-4d4d-bb11-a270acf5ef7f, Rescigno, M. (Maria)|||/items/33e8d0be-fcd6-4d2f-9a34-94f9c53009db, Riganti, C. (Chiara)|||/items/cdee6f87-3e56-446c-815d-90b138051416, Sistigu, A. (Antonella)|||/items/213b1d98-cfbb-45eb-a2be-4bb51fd81a3e, Smyth, M.J. (Mark J.)|||/items/5543b488-243d-43b1-ba90-98634818aa58, Spisek, R. (Radek)|||/items/8076e046-13b6-4154-b2b3-c43fa0c4bfd2, Stagg, J. (John)|||/items/a1c58830-b446-4e9d-bbef-44ac198606c5, Strauss, B.E. (Bryan E.)|||/items/98d56cd3-d217-4331-8d22-8e8815fcad21, Tang, D. (Daolin)|||/items/801aefa9-d401-4b3f-b968-d2968e7530a4, Tatsuno, K. (Kazuko)|||/items/28c69efb-a468-4d1a-99c0-0689c6eda34b, Gool, S.W. (Stefaan W.) van|||/items/e8e0789d-0cbb-4406-ab93-e4e4ae07f7aa, Vandenabeele, P. (Peter)|||/items/f8ba98e3-bf62-4998-bee2-a2051af13e9d, Yamazaki, T. (Takahiro)|||/items/94725f58-7690-4476-83e5-45187bb94082, Zamarin, D. (Dmitriy)|||/items/4e6f38db-675b-4cea-8234-4e045ae1123b, Zitvogel, L. (Laurence)|||/items/ad85ff59-7ca2-4f87-8931-a921648eb97b, Cesano, A. (Alessandra)|||/items/78f96971-0af2-4ada-96bc-be26363b487f, Marincola, F.M. (Francesco M.)|||/items/395db413-7b2d-4710-8fc2-ad614536c516
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/66750
Acesso em linha:https://hdl.handle.net/10171/66750
Access Level:acceso abierto
Palavra-chave:Immunology
Molecular biology
Oncology
Descrição
Resumo:Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

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