Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity

Microbes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukary-otes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasi...

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Autores: Safi, Rémi, Sánchez-Álvarez, Miguel, Bosch, Marta, Demangel, Caroline, Parton, Robert G., Pol, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349450
Acceso en línea:http://hdl.handle.net/10261/349450
Access Level:acceso abierto
Palabra clave:Bacteria
Innate immunity
Interferon
Lipid droplets
Parasites
Virus
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spelling Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunitySafi, RémiSánchez-Álvarez, MiguelBosch, MartaDemangel, CarolineParton, Robert G.Pol, AlbertBacteriaInnate immunityInterferonLipid dropletsParasitesVirusMicrobes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukary-otes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and the current view is that they “hijack” LDs to draw on substrates for host colonization. This dogma has been challenged by the recent demonstration that LDs are endowed with a protein- mediated antibiotic activity, which is upregulated in response to danger signals and sepsis. Dependence on host nutrients could be a generic “Achilles’ heel” of intracellular pathogens and LDs a suitable chokepoint harnessed by innate immunity to organize a front- line defense. Here, we will provide a brief overview of the state of the conflict and discuss potential mechanisms driving the formation of the ‘defensive- LDs’ functioning as hubs of innate immunity.RS is recipient of the Lady Tata Memorial Trust grant for leukemia research and the Marie Skłodowska-Curie Actions Postdoctoral Fellowship (MSCA-PF) granted by the European commission. MS-A is recipient of a Ramón y Cajal researcher contract and a research grant from the Spanish Ministerio de Innovación y Ciencia (RYC2020-029690 and PID2021-128106NA-I00). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the MCIN and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). AP and MB are supported by I+D+i RETOS INVESTIGACIÓN from the Ministerio de Ciencia e Investigación (MICINN, PID2021-127043OB-I00) and the CERCA Programme/Generalitat de Catalunya. AP is supported by the H2020-MSCA-ITN-2018, 953489 (ENDOCONNECT). RGP is a Laureate Fellow of the Australian Research Council. AP, RGP, and CD are supported by the ERC Synergy Grant ERC-2022-SYG, 101071784 (DRIMMS). Figures were generated using Adobe Photoshop (Adobe), Powerpoint (Microsoft), Graphpad Prism (Dotmatics), and BioRender.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2020-001041-S).Peer reviewedJohn Wiley & SonsLady Tata Memorial TrustEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIICentro Nacional de Investigaciones Oncológicas (España)Ministerio de Ciencia e Innovación (España)Generalitat de CatalunyaAustralian Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/349450reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//RYC2020-029690info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-128106NA-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2020-001041-Sinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127043OB-I00info:eu-repo/grantAgreement/EC/H2020/953489info:eu-repo/grantAgreement/EC/HE/101071784https://doi.org/10.1111/imr.13199Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3494502026-05-22T06:33:51Z
dc.title.none.fl_str_mv Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
title Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
spellingShingle Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
Safi, Rémi
Bacteria
Innate immunity
Interferon
Lipid droplets
Parasites
Virus
title_short Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
title_full Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
title_fullStr Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
title_full_unstemmed Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
title_sort Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity
dc.creator.none.fl_str_mv Safi, Rémi
Sánchez-Álvarez, Miguel
Bosch, Marta
Demangel, Caroline
Parton, Robert G.
Pol, Albert
author Safi, Rémi
author_facet Safi, Rémi
Sánchez-Álvarez, Miguel
Bosch, Marta
Demangel, Caroline
Parton, Robert G.
Pol, Albert
author_role author
author2 Sánchez-Álvarez, Miguel
Bosch, Marta
Demangel, Caroline
Parton, Robert G.
Pol, Albert
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Lady Tata Memorial Trust
European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
Centro Nacional de Investigaciones Oncológicas (España)
Ministerio de Ciencia e Innovación (España)
Generalitat de Catalunya
Australian Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bacteria
Innate immunity
Interferon
Lipid droplets
Parasites
Virus
topic Bacteria
Innate immunity
Interferon
Lipid droplets
Parasites
Virus
description Microbes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukary-otes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and the current view is that they “hijack” LDs to draw on substrates for host colonization. This dogma has been challenged by the recent demonstration that LDs are endowed with a protein- mediated antibiotic activity, which is upregulated in response to danger signals and sepsis. Dependence on host nutrients could be a generic “Achilles’ heel” of intracellular pathogens and LDs a suitable chokepoint harnessed by innate immunity to organize a front- line defense. Here, we will provide a brief overview of the state of the conflict and discuss potential mechanisms driving the formation of the ‘defensive- LDs’ functioning as hubs of innate immunity.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/349450
url http://hdl.handle.net/10261/349450
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//RYC2020-029690
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-128106NA-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2020-001041-S
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127043OB-I00
info:eu-repo/grantAgreement/EC/H2020/953489
info:eu-repo/grantAgreement/EC/HE/101071784
https://doi.org/10.1111/imr.13199
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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