(2E)-4-Methoxy-2,4-pentadienamides as New Dienes in the Diels-Alder Reaction

(2E)-4-Methoxy-2,4-pentadienamides have been stereoselectively prepared by treatment of (2E,4E)-5-tosyl-2,4-pentadienamides with 1M methanolic potassium hydroxide in good yields. They behave as new electron-rich dienes in Diels-Alder reactions to give stereoselectively highly functionalized adducts...

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Detalles Bibliográficos
Autores: Bernabeu, M.C., Chinchilla, R. [0000-0002-9894-1671], Nájera, C. [0000-0003-0063-5527], Rodríguez, M.A. [0000-0003-0123-9905]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1996
País:España
Institución:Universidad de La Rioja (UR)
Repositorio:RIUR. Repositorio Institucional de la Universidad de La Rioja
OAI Identifier:oai:portal.dialnet.es:doc/5bbc68e2b750603269e81147
Acceso en línea:https://investigacion.unirioja.es/documentos/5bbc68e2b750603269e81147
Access Level:acceso abierto
Descripción
Sumario:(2E)-4-Methoxy-2,4-pentadienamides have been stereoselectively prepared by treatment of (2E,4E)-5-tosyl-2,4-pentadienamides with 1M methanolic potassium hydroxide in good yields. They behave as new electron-rich dienes in Diels-Alder reactions to give stereoselectively highly functionalized adducts 3 mainly with endo-selectivity and, after hydrolysis, only their corresponding cyclohexanone derivatives 4. Semi-empirical calculations corroborate their reactivity.