Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models

Pancreatic Ductal Adenocarcinoma (PDAC) therapies show limited success./nIrreversible electroporation (IRE) is an innovative loco-regional therapy in which highvoltage pulses are applied to induce plasma membrane defects leading to cellular death. In the present study we evaluated the feasibility of...

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Authors: José Segarra-Martínez, Anabel, Sobrevals, Luciano, Ivorra Cano, Antoni, 1974-, Fillat i Fonts, Cristina
Format: article
Status:Versión aceptada para publicación
Publication Date:2012
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26250
Online Access:http://hdl.handle.net/10230/26250
http://dx.doi.org/10.1016/j.canlet.2011.11.004
Access Level:Open access
Keyword:Pancreatic ductal adenocarcinoma
Irreversible electroporation
Orthotopic pancreatic cancer xenografts
Bioluminescent imaging
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spelling Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse modelsJosé Segarra-Martínez, AnabelSobrevals, LucianoIvorra Cano, Antoni, 1974-Fillat i Fonts, CristinaPancreatic ductal adenocarcinomaIrreversible electroporationOrthotopic pancreatic cancer xenograftsBioluminescent imagingPancreatic Ductal Adenocarcinoma (PDAC) therapies show limited success./nIrreversible electroporation (IRE) is an innovative loco-regional therapy in which highvoltage pulses are applied to induce plasma membrane defects leading to cellular death. In the present study we evaluated the feasibility of IRE against PDAC. IRE/ntreatment exhibited significant antitumor effects and prolonged survival in mice with orthotopic xenografts. Extensive tumor necrosis, reduced tumor cell proliferation and disruption of microvessels were observed at different days post-IRE. Animals had transient increases in transaminases, amylase and lipase enzymes that normalized at/n24h post-IRE. These results suggest that IRE could be an effective treatment for locally advanced pancreatic tumors.This work was supported by the Spanish/nMinistry of Science and Innovation (MICINN), BIO2008-04692-C03-02/01 and received/npartial support from the Generalitat de Catalunya SGR091527. Anabel José was a/nrecipient of a FPU fellowship from the MICINN. Fillat’s group is also partially funded by/nCIBERER and by IIS10/00014 from Instituto de Salud Carlos III. Ivorra’s research is/ncurrently supported by a Ramón y Cajal fellowship from the Spanish Ministry for/nScience and Innovation and a Marie Curie IRG grant from the European Commission.Elsevier201620162012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26250http://dx.doi.org/10.1016/j.canlet.2011.11.004reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCancer letters. 2012;317(1):16-23.info:eu-repo/grantAgreement/EC/FP7/256376info:eu-repo/grantAgreement/ES/3PN/BIO2008-04692-C03-02© Elsevier http://dx.doi.org/10.1016/j.canlet.2011.11.004info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/262502026-06-12T07:21:37Z
dc.title.none.fl_str_mv Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
title Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
spellingShingle Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
José Segarra-Martínez, Anabel
Pancreatic ductal adenocarcinoma
Irreversible electroporation
Orthotopic pancreatic cancer xenografts
Bioluminescent imaging
title_short Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
title_full Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
title_fullStr Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
title_full_unstemmed Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
title_sort Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
dc.creator.none.fl_str_mv José Segarra-Martínez, Anabel
Sobrevals, Luciano
Ivorra Cano, Antoni, 1974-
Fillat i Fonts, Cristina
author José Segarra-Martínez, Anabel
author_facet José Segarra-Martínez, Anabel
Sobrevals, Luciano
Ivorra Cano, Antoni, 1974-
Fillat i Fonts, Cristina
author_role author
author2 Sobrevals, Luciano
Ivorra Cano, Antoni, 1974-
Fillat i Fonts, Cristina
author2_role author
author
author
dc.subject.none.fl_str_mv Pancreatic ductal adenocarcinoma
Irreversible electroporation
Orthotopic pancreatic cancer xenografts
Bioluminescent imaging
topic Pancreatic ductal adenocarcinoma
Irreversible electroporation
Orthotopic pancreatic cancer xenografts
Bioluminescent imaging
description Pancreatic Ductal Adenocarcinoma (PDAC) therapies show limited success./nIrreversible electroporation (IRE) is an innovative loco-regional therapy in which highvoltage pulses are applied to induce plasma membrane defects leading to cellular death. In the present study we evaluated the feasibility of IRE against PDAC. IRE/ntreatment exhibited significant antitumor effects and prolonged survival in mice with orthotopic xenografts. Extensive tumor necrosis, reduced tumor cell proliferation and disruption of microvessels were observed at different days post-IRE. Animals had transient increases in transaminases, amylase and lipase enzymes that normalized at/n24h post-IRE. These results suggest that IRE could be an effective treatment for locally advanced pancreatic tumors.
publishDate 2012
dc.date.none.fl_str_mv 2012
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26250
http://dx.doi.org/10.1016/j.canlet.2011.11.004
url http://hdl.handle.net/10230/26250
http://dx.doi.org/10.1016/j.canlet.2011.11.004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancer letters. 2012;317(1):16-23.
info:eu-repo/grantAgreement/EC/FP7/256376
info:eu-repo/grantAgreement/ES/3PN/BIO2008-04692-C03-02
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.canlet.2011.11.004
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.canlet.2011.11.004
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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