Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder

Aim: To analyze cognitive reserve (CR) in child and adolescent offspring of patients diagnosed with schizophrenia (SZ-off) or bipolar disorder (BD-off) and compare them with a group of community controls (CC-off). We also aimed to investigate whether there was an association between CR and clinical...

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Autores: Baeza, Inmaculada, 1970-, Castro Fornieles, Josefina, Camprodon Boadas, Patricia, Moreno, Dolores, Rosa Justicia, Mireia, Sugranyes, Gisela, Ilzarbe Simorte, Daniel, Martínez Díaz-Caneja, Covadonga, Ayora, Miriam, Merchán, Jessica, Martín, Nuria, Borràs, Roger, García Rizo, Clemente, Torrent Font, Carla, Serna, Elena de la, 1978-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/210140
Acceso en línea:https://hdl.handle.net/2445/210140
Access Level:acceso abierto
Palabra clave:Trastorn bipolar
Esquizofrènia
Psicopatologia
Manic-depressive illness
Schizophrenia
Pathological psychology
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spelling Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorderBaeza, Inmaculada, 1970-Castro Fornieles, JosefinaCamprodon Boadas, PatriciaMoreno, DoloresRosa Justicia, MireiaSugranyes, GiselaIlzarbe Simorte, DanielMartínez Díaz-Caneja, CovadongaAyora, MiriamMerchán, JessicaMartín, NuriaBorràs, RogerGarcía Rizo, ClementeTorrent Font, CarlaSerna, Elena de la, 1978-Trastorn bipolarEsquizofrèniaPsicopatologiaManic-depressive illnessSchizophreniaPathological psychologyAim: To analyze cognitive reserve (CR) in child and adolescent offspring of patients diagnosed with schizophrenia (SZ-off) or bipolar disorder (BD-off) and compare them with a group of community controls (CC-off). We also aimed to investigate whether there was an association between CR and clinical and neuropsychological variables according to group. Methods: The study included 46 SZ-off, 105 BD-off and 102 CC-off. All participants completed assessments regarding CR and clinical, neuropsychological and psychosocial functioning. CR was measured with a proxy based on premorbid intelligence, parental occupational level, educational attainment, developmental milestones and sociability. The clinical assessment included the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime, the Semi-structured Interview for Prodromal Syndromes, and the Global Assessment Functioning scale. The neuropsychological assessment included measures of executive functioning, attention, verbal memory, working memory and processing speed. Results: SZ-off showed a lower level of CR compared to BD-off and CC-off, while BD-off showed an intermediate level of CR between SZ-off and CC-off. Moreover, an association between higher CR and less lifetime psychopathology, fewer prodromal psychotic symptoms, higher psychosocial functioning, and a higher working memory score was observed in all groups, but it was stronger in SZ-off. Conclusions: CR seemed to be associated with psychopathology, clinical symptoms, psychosocial functioning, and some cognitive functions. SZ-off appeared to benefit more from a higher CR, therefore it could be considered a protective factor against the development of clinical symptomatology and cognitive impairment.Springer Verlag2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/210140Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1007/s00787-022-01957-0European Child & Adolescent Psychiatry, 2023, vol. 32, p. 1463-1473https://doi.org/10.1007/s00787-022-01957-0(c) Springer Verlag, 2023info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2101402026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
title Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
spellingShingle Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
Baeza, Inmaculada, 1970-
Trastorn bipolar
Esquizofrènia
Psicopatologia
Manic-depressive illness
Schizophrenia
Pathological psychology
title_short Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
title_full Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
title_fullStr Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
title_full_unstemmed Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
title_sort Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder
dc.creator.none.fl_str_mv Baeza, Inmaculada, 1970-
Castro Fornieles, Josefina
Camprodon Boadas, Patricia
Moreno, Dolores
Rosa Justicia, Mireia
Sugranyes, Gisela
Ilzarbe Simorte, Daniel
Martínez Díaz-Caneja, Covadonga
Ayora, Miriam
Merchán, Jessica
Martín, Nuria
Borràs, Roger
García Rizo, Clemente
Torrent Font, Carla
Serna, Elena de la, 1978-
author Baeza, Inmaculada, 1970-
author_facet Baeza, Inmaculada, 1970-
Castro Fornieles, Josefina
Camprodon Boadas, Patricia
Moreno, Dolores
Rosa Justicia, Mireia
Sugranyes, Gisela
Ilzarbe Simorte, Daniel
Martínez Díaz-Caneja, Covadonga
Ayora, Miriam
Merchán, Jessica
Martín, Nuria
Borràs, Roger
García Rizo, Clemente
Torrent Font, Carla
Serna, Elena de la, 1978-
author_role author
author2 Castro Fornieles, Josefina
Camprodon Boadas, Patricia
Moreno, Dolores
Rosa Justicia, Mireia
Sugranyes, Gisela
Ilzarbe Simorte, Daniel
Martínez Díaz-Caneja, Covadonga
Ayora, Miriam
Merchán, Jessica
Martín, Nuria
Borràs, Roger
García Rizo, Clemente
Torrent Font, Carla
Serna, Elena de la, 1978-
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorn bipolar
Esquizofrènia
Psicopatologia
Manic-depressive illness
Schizophrenia
Pathological psychology
topic Trastorn bipolar
Esquizofrènia
Psicopatologia
Manic-depressive illness
Schizophrenia
Pathological psychology
description Aim: To analyze cognitive reserve (CR) in child and adolescent offspring of patients diagnosed with schizophrenia (SZ-off) or bipolar disorder (BD-off) and compare them with a group of community controls (CC-off). We also aimed to investigate whether there was an association between CR and clinical and neuropsychological variables according to group. Methods: The study included 46 SZ-off, 105 BD-off and 102 CC-off. All participants completed assessments regarding CR and clinical, neuropsychological and psychosocial functioning. CR was measured with a proxy based on premorbid intelligence, parental occupational level, educational attainment, developmental milestones and sociability. The clinical assessment included the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime, the Semi-structured Interview for Prodromal Syndromes, and the Global Assessment Functioning scale. The neuropsychological assessment included measures of executive functioning, attention, verbal memory, working memory and processing speed. Results: SZ-off showed a lower level of CR compared to BD-off and CC-off, while BD-off showed an intermediate level of CR between SZ-off and CC-off. Moreover, an association between higher CR and less lifetime psychopathology, fewer prodromal psychotic symptoms, higher psychosocial functioning, and a higher working memory score was observed in all groups, but it was stronger in SZ-off. Conclusions: CR seemed to be associated with psychopathology, clinical symptoms, psychosocial functioning, and some cognitive functions. SZ-off appeared to benefit more from a higher CR, therefore it could be considered a protective factor against the development of clinical symptomatology and cognitive impairment.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/210140
url https://hdl.handle.net/2445/210140
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/s00787-022-01957-0
European Child & Adolescent Psychiatry, 2023, vol. 32, p. 1463-1473
https://doi.org/10.1007/s00787-022-01957-0
dc.rights.none.fl_str_mv (c) Springer Verlag, 2023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Verlag, 2023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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