Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain

Monoaminergic systems, including serotonin, dopamine, and norepinephrine, are essential for regulating brain activity and facilitating behavioral flexibility. These systems originate from brainstem nuclei and project widely to modulate functions such as mood, attention, memory, and adaptability. Usi...

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Autores: Saiz-Masvidal, C, De la Peña-Arteaga, V, Bertolín, S, Diez, I, Juaneda-Seguí, A, Martínez-Zalacaín, I, Chavarría-Elizondo, P, Subirà, M, Menchón, JM, Sepulcre, J, Fullana, MA, Soriano-Mas, C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p20257
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20257
Access Level:acceso abierto
Palabra clave:Monoaminergic signaling
Resting-state functional magnetic resonance imaging
Resting-state functional connectivity
Resting-state networks
Neurotransmitter mapping
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spelling Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brainSaiz-Masvidal, CDe la Peña-Arteaga, VBertolín, SDiez, IJuaneda-Seguí, AMartínez-Zalacaín, IChavarría-Elizondo, PSubirà, MMenchón, JMSepulcre, JFullana, MASoriano-Mas, CMonoaminergic signalingResting-state functional magnetic resonance imagingResting-state functional connectivityResting-state networksNeurotransmitter mappingMonoaminergic systems, including serotonin, dopamine, and norepinephrine, are essential for regulating brain activity and facilitating behavioral flexibility. These systems originate from brainstem nuclei and project widely to modulate functions such as mood, attention, memory, and adaptability. Using resting-state functional MRI (rs-fMRI), this study aimed to investigate the connectivity networks of key monoaminergic nuclei in 193 healthy adults and explore their correspondence with molecular imaging maps of neurotransmitter-specific biochemical markers. Functional connectivity (FC) was assessed using seed-based rs-fMRI analyses with seeds placed in the dorsal raphe nucleus (DRN), nucleus centralis superior (NCS), ventral tegmental area (VTA), substantia nigra pars compacta (SNc), and locus coeruleus (LC). Cross-modal analyses using molecular imaging data were performed to correlate these rs-FC maps with the distribution of neurotransmitter-related receptors, transporters, and synthesis enzymes, providing insights into the molecular architecture underlying the FC of monoaminergic systems. Whole-brain FC maps revealed distinct patterns for each nucleus. DRN projections were extensive, connecting to subcortical regions such as the hippocampus and amygdala and cortical areas including the precuneus, cingulate, and medial frontal cortex. NCS projections overlapped partially but uniquely targeted the orbitofrontal and insular cortices. Dopaminergic pathways exhibited connectivity with the striatum, thalamus, and prefrontal cortex, while noradrenergic LC projections displayed lateralized connectivity to occipital, temporal, and frontal regions. Cross-modal correlations with molecular imaging demonstrated significant spatial associations between rs-FC maps and neurotransmitter-specific markers, including 5HTT, DAT, and FDOPA. This study enhances our understanding of neurotransmitter networks, highlighting their relevance in brain function and potential as biomarkers for neuropsychiatric conditions.SPRINGER HEIDELBERG2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20257Brain Structure & FunctionISSN: 18632653ISSNe: 18632661reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p202572026-06-14T12:41:47Z
dc.title.none.fl_str_mv Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
spellingShingle Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
Saiz-Masvidal, C
Monoaminergic signaling
Resting-state functional magnetic resonance imaging
Resting-state functional connectivity
Resting-state networks
Neurotransmitter mapping
title_short Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_full Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_fullStr Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_full_unstemmed Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_sort Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
dc.creator.none.fl_str_mv Saiz-Masvidal, C
De la Peña-Arteaga, V
Bertolín, S
Diez, I
Juaneda-Seguí, A
Martínez-Zalacaín, I
Chavarría-Elizondo, P
Subirà, M
Menchón, JM
Sepulcre, J
Fullana, MA
Soriano-Mas, C
author Saiz-Masvidal, C
author_facet Saiz-Masvidal, C
De la Peña-Arteaga, V
Bertolín, S
Diez, I
Juaneda-Seguí, A
Martínez-Zalacaín, I
Chavarría-Elizondo, P
Subirà, M
Menchón, JM
Sepulcre, J
Fullana, MA
Soriano-Mas, C
author_role author
author2 De la Peña-Arteaga, V
Bertolín, S
Diez, I
Juaneda-Seguí, A
Martínez-Zalacaín, I
Chavarría-Elizondo, P
Subirà, M
Menchón, JM
Sepulcre, J
Fullana, MA
Soriano-Mas, C
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Monoaminergic signaling
Resting-state functional magnetic resonance imaging
Resting-state functional connectivity
Resting-state networks
Neurotransmitter mapping
topic Monoaminergic signaling
Resting-state functional magnetic resonance imaging
Resting-state functional connectivity
Resting-state networks
Neurotransmitter mapping
description Monoaminergic systems, including serotonin, dopamine, and norepinephrine, are essential for regulating brain activity and facilitating behavioral flexibility. These systems originate from brainstem nuclei and project widely to modulate functions such as mood, attention, memory, and adaptability. Using resting-state functional MRI (rs-fMRI), this study aimed to investigate the connectivity networks of key monoaminergic nuclei in 193 healthy adults and explore their correspondence with molecular imaging maps of neurotransmitter-specific biochemical markers. Functional connectivity (FC) was assessed using seed-based rs-fMRI analyses with seeds placed in the dorsal raphe nucleus (DRN), nucleus centralis superior (NCS), ventral tegmental area (VTA), substantia nigra pars compacta (SNc), and locus coeruleus (LC). Cross-modal analyses using molecular imaging data were performed to correlate these rs-FC maps with the distribution of neurotransmitter-related receptors, transporters, and synthesis enzymes, providing insights into the molecular architecture underlying the FC of monoaminergic systems. Whole-brain FC maps revealed distinct patterns for each nucleus. DRN projections were extensive, connecting to subcortical regions such as the hippocampus and amygdala and cortical areas including the precuneus, cingulate, and medial frontal cortex. NCS projections overlapped partially but uniquely targeted the orbitofrontal and insular cortices. Dopaminergic pathways exhibited connectivity with the striatum, thalamus, and prefrontal cortex, while noradrenergic LC projections displayed lateralized connectivity to occipital, temporal, and frontal regions. Cross-modal correlations with molecular imaging demonstrated significant spatial associations between rs-FC maps and neurotransmitter-specific markers, including 5HTT, DAT, and FDOPA. This study enhances our understanding of neurotransmitter networks, highlighting their relevance in brain function and potential as biomarkers for neuropsychiatric conditions.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20257
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20257
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER HEIDELBERG
publisher.none.fl_str_mv SPRINGER HEIDELBERG
dc.source.none.fl_str_mv Brain Structure & Function
ISSN: 18632653
ISSNe: 18632661
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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