Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila

In bilateral animals, the left and right sides of the body usually present asymmetric structures, the genetic bases of whose generation are still largely unknown [CIBA Foundation (1991) Biological Asymmetry and Handedness, CIBA Foundation Symposium 162 (Wiley, New York), pp. 1-327]. In Drosophila me...

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Detalles Bibliográficos
Autores: Martín-Blanco, Enrique, García-Bellido, Antonio
Tipo de recurso: artículo
Fecha de publicación:1996
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/48126
Acceso en línea:http://hdl.handle.net/10261/48126
Access Level:acceso embargado
Palabra clave:Drosophila
Metamorphosis
Bilateral
Asymmetry
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spelling Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in DrosophilaMartín-Blanco, EnriqueGarcía-Bellido, AntonioDrosophilaMetamorphosisBilateralAsymmetryIn bilateral animals, the left and right sides of the body usually present asymmetric structures, the genetic bases of whose generation are still largely unknown [CIBA Foundation (1991) Biological Asymmetry and Handedness, CIBA Foundation Symposium 162 (Wiley, New York), pp. 1-327]. In Drosophila melanogaster, mutations in the rotated abdomen (rt) locus cause a clockwise helical rotation of the body. Even null alleles are viable but exhibit defects in embryonic muscle development, rotation of the whole larval body, and helical staggering of cuticular patterns in abdominal segments of the adult. rotated abdomen is expressed in the embryonic mesoderm and midgut but not in the ectoderm; it encodes a putative integral membrane glycoprotein (homologous to key yeast mannosyltransferases). Mesodermal cells defective in O-glycosylation lead to an impaired larval muscular system. We propose that the staggering of the adult abdominal segments would be a consequence of the relaxation of intrinsic rotational torque of muscle architecture, preventing the colateral alignment of the segmental histoblast cells during their proliferation at metamorphosis.Peer reviewedNational Academy of Sciences (U.S.)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220121996info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/48126reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1073/pnas.93.12.6048Síinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/481262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
title Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
spellingShingle Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
Martín-Blanco, Enrique
Drosophila
Metamorphosis
Bilateral
Asymmetry
title_short Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
title_full Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
title_fullStr Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
title_full_unstemmed Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
title_sort Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila
dc.creator.none.fl_str_mv Martín-Blanco, Enrique
García-Bellido, Antonio
author Martín-Blanco, Enrique
author_facet Martín-Blanco, Enrique
García-Bellido, Antonio
author_role author
author2 García-Bellido, Antonio
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila
Metamorphosis
Bilateral
Asymmetry
topic Drosophila
Metamorphosis
Bilateral
Asymmetry
description In bilateral animals, the left and right sides of the body usually present asymmetric structures, the genetic bases of whose generation are still largely unknown [CIBA Foundation (1991) Biological Asymmetry and Handedness, CIBA Foundation Symposium 162 (Wiley, New York), pp. 1-327]. In Drosophila melanogaster, mutations in the rotated abdomen (rt) locus cause a clockwise helical rotation of the body. Even null alleles are viable but exhibit defects in embryonic muscle development, rotation of the whole larval body, and helical staggering of cuticular patterns in abdominal segments of the adult. rotated abdomen is expressed in the embryonic mesoderm and midgut but not in the ectoderm; it encodes a putative integral membrane glycoprotein (homologous to key yeast mannosyltransferases). Mesodermal cells defective in O-glycosylation lead to an impaired larval muscular system. We propose that the staggering of the adult abdominal segments would be a consequence of the relaxation of intrinsic rotational torque of muscle architecture, preventing the colateral alignment of the segmental histoblast cells during their proliferation at metamorphosis.
publishDate 1996
dc.date.none.fl_str_mv 1996
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/48126
url http://hdl.handle.net/10261/48126
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1073/pnas.93.12.6048
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv National Academy of Sciences (U.S.)
publisher.none.fl_str_mv National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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