Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression

Ovarian cancer is the most lethal gynaecological cancer and is often diagnosed in late stage, often as the result of the unavailability of sufficiently sensitive biomarkers for early detection, tumour progression and tumour-associated inflammation. Glycosylation is the most common posttranslational...

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Autores: Saldova, Radka, Piccard, Helene, Pérez Garay, Marta, Harvey, David J., Struwe, Weston B., Galligan, Marie, Berghmans, Nele, Madden, Stephen F., Peracaula Miró, Rosa, Opdenakker, Ghislain, Rudd, Pauline M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/16064
Acesso em linha:http://hdl.handle.net/10256/16064
Access Level:acceso abierto
Palavra-chave:Ovaris -- Càncer
Ovaries -- Cancer
Marcadors tumorals
Tumor markers
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spelling Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour ProgressionSaldova, RadkaPiccard, HelenePérez Garay, MartaHarvey, David J.Struwe, Weston B.Galligan, MarieBerghmans, NeleMadden, Stephen F.Peracaula Miró, RosaOpdenakker, GhislainRudd, Pauline M.Ovaris -- CàncerOvaries -- CancerMarcadors tumoralsTumor markersOvarian cancer is the most lethal gynaecological cancer and is often diagnosed in late stage, often as the result of the unavailability of sufficiently sensitive biomarkers for early detection, tumour progression and tumour-associated inflammation. Glycosylation is the most common posttranslational modification of proteins; it is altered in cancer and therefore is a potential source of biomarkers. We investigated the quantitative and qualitative effects of anti-inflammatory (acetylsalicylic acid) and pro-inflammatory (thioglycolate and chlorite-oxidized oxyamylose) drugs on glycosylation in mouse cancer serum. A significant increase in sialylation and branching of glycans in mice treated with an inflammation-inducing compound was observed. Moreover, the increases in sialylation correlated with increased tumour sizes. Increases in sialylation and branching were consistent with increased expression of sialyltransferases and the branching enzyme MGAT5. Because the sialyltransferases are highly conserved among species, the described changes in the ovarian cancer mouse model are relevant to humans and serum N-glycome analysis for monitoring disease treatment and progression might be a useful biomarkerPublic Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/16064http://hdl.handle.net/10256/16064PLoS ONE, 2013, vol. 8, núm. 8, p. e71159Articles publicats (D-B)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0071159info:eu-repo/semantics/altIdentifier/eissn/1932-6203Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/160642026-05-29T05:05:01Z
dc.title.none.fl_str_mv Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
title Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
spellingShingle Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
Saldova, Radka
Ovaris -- Càncer
Ovaries -- Cancer
Marcadors tumorals
Tumor markers
title_short Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
title_full Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
title_fullStr Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
title_full_unstemmed Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
title_sort Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression
dc.creator.none.fl_str_mv Saldova, Radka
Piccard, Helene
Pérez Garay, Marta
Harvey, David J.
Struwe, Weston B.
Galligan, Marie
Berghmans, Nele
Madden, Stephen F.
Peracaula Miró, Rosa
Opdenakker, Ghislain
Rudd, Pauline M.
author Saldova, Radka
author_facet Saldova, Radka
Piccard, Helene
Pérez Garay, Marta
Harvey, David J.
Struwe, Weston B.
Galligan, Marie
Berghmans, Nele
Madden, Stephen F.
Peracaula Miró, Rosa
Opdenakker, Ghislain
Rudd, Pauline M.
author_role author
author2 Piccard, Helene
Pérez Garay, Marta
Harvey, David J.
Struwe, Weston B.
Galligan, Marie
Berghmans, Nele
Madden, Stephen F.
Peracaula Miró, Rosa
Opdenakker, Ghislain
Rudd, Pauline M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ovaris -- Càncer
Ovaries -- Cancer
Marcadors tumorals
Tumor markers
topic Ovaris -- Càncer
Ovaries -- Cancer
Marcadors tumorals
Tumor markers
description Ovarian cancer is the most lethal gynaecological cancer and is often diagnosed in late stage, often as the result of the unavailability of sufficiently sensitive biomarkers for early detection, tumour progression and tumour-associated inflammation. Glycosylation is the most common posttranslational modification of proteins; it is altered in cancer and therefore is a potential source of biomarkers. We investigated the quantitative and qualitative effects of anti-inflammatory (acetylsalicylic acid) and pro-inflammatory (thioglycolate and chlorite-oxidized oxyamylose) drugs on glycosylation in mouse cancer serum. A significant increase in sialylation and branching of glycans in mice treated with an inflammation-inducing compound was observed. Moreover, the increases in sialylation correlated with increased tumour sizes. Increases in sialylation and branching were consistent with increased expression of sialyltransferases and the branching enzyme MGAT5. Because the sialyltransferases are highly conserved among species, the described changes in the ovarian cancer mouse model are relevant to humans and serum N-glycome analysis for monitoring disease treatment and progression might be a useful biomarker
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/16064
http://hdl.handle.net/10256/16064
url http://hdl.handle.net/10256/16064
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0071159
info:eu-repo/semantics/altIdentifier/eissn/1932-6203
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv PLoS ONE, 2013, vol. 8, núm. 8, p. e71159
Articles publicats (D-B)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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