ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample

Background Dopamine is believed to be a key neurotransmitter in the development of attention-deficit/ hyperactivity disorder (ADHD). Several recent studies point to an association of the dopamine D4 receptor (DRD4) gene and this condition. More specifically, the 7 repeat variant of a variable number...

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Autores: Krämer, Ulrike M., Rojo Fité, Nuria, Schüle, Rebecca, Cunillera, Toni, Schöls, Ludger, Marco Pallarés, Josep, Cucurell, David, Camara Mancha, Estela, Rodríguez Fornells, Antoni, Münte, Thomas F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/56825
Acceso en línea:https://hdl.handle.net/2445/56825
Access Level:acceso abierto
Palabra clave:Neurotransmissors
Dopamina
Neurofisiologia
Neurotransmitters
Dopamine
Neurophysiology
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spelling ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sampleKrämer, Ulrike M.Rojo Fité, NuriaSchüle, RebeccaCunillera, ToniSchöls, LudgerMarco Pallarés, JosepCucurell, DavidCamara Mancha, EstelaRodríguez Fornells, AntoniMünte, Thomas F.NeurotransmissorsDopaminaNeurofisiologiaNeurotransmittersDopamineNeurophysiologyBackground Dopamine is believed to be a key neurotransmitter in the development of attention-deficit/ hyperactivity disorder (ADHD). Several recent studies point to an association of the dopamine D4 receptor (DRD4) gene and this condition. More specifically, the 7 repeat variant of a variable number of tandem repeats (VNTR) polymorphism in exon III of this gene is suggested to bear a higher risk for ADHD. In the present study, we investigated the role of this polymorphism in the modulation of neurophysiological correlates of response inhibition (Go/Nogo task) in a healthy, high-functioning sample. Results Homozygous 7 repeat carriers showed a tendency for more accurate behavior in the Go/Nogo task compared to homozygous 4 repeat carriers. Moreover, 7 repeat carriers presented an increased nogo-related theta band response together with a reduced go-related beta decrease. Conclusions These data point to improved cognitive functions and prefrontal control in the 7 repeat carriers, probably due to the D4 receptor's modulatory role in prefrontal areas. The results are discussed with respect to previous behavioral data on this polymorphism and animal studies on the impact of the D4 receptor on cognitive functions.BioMed Central2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/56825Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1186/1471-2202-10-150; http://dx.doi.org/10.1186/1471-2202-10-150BMC Neuroscience, 2009, vol. 10, num. 150http://dx.doi.org/10.1186/1471-2202-10-150cc-by (c) Krämer, UM. et al., 2009http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/568252026-05-27T06:46:51Z
dc.title.none.fl_str_mv ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
title ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
spellingShingle ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
Krämer, Ulrike M.
Neurotransmissors
Dopamina
Neurofisiologia
Neurotransmitters
Dopamine
Neurophysiology
title_short ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
title_full ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
title_fullStr ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
title_full_unstemmed ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
title_sort ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
dc.creator.none.fl_str_mv Krämer, Ulrike M.
Rojo Fité, Nuria
Schüle, Rebecca
Cunillera, Toni
Schöls, Ludger
Marco Pallarés, Josep
Cucurell, David
Camara Mancha, Estela
Rodríguez Fornells, Antoni
Münte, Thomas F.
author Krämer, Ulrike M.
author_facet Krämer, Ulrike M.
Rojo Fité, Nuria
Schüle, Rebecca
Cunillera, Toni
Schöls, Ludger
Marco Pallarés, Josep
Cucurell, David
Camara Mancha, Estela
Rodríguez Fornells, Antoni
Münte, Thomas F.
author_role author
author2 Rojo Fité, Nuria
Schüle, Rebecca
Cunillera, Toni
Schöls, Ludger
Marco Pallarés, Josep
Cucurell, David
Camara Mancha, Estela
Rodríguez Fornells, Antoni
Münte, Thomas F.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurotransmissors
Dopamina
Neurofisiologia
Neurotransmitters
Dopamine
Neurophysiology
topic Neurotransmissors
Dopamina
Neurofisiologia
Neurotransmitters
Dopamine
Neurophysiology
description Background Dopamine is believed to be a key neurotransmitter in the development of attention-deficit/ hyperactivity disorder (ADHD). Several recent studies point to an association of the dopamine D4 receptor (DRD4) gene and this condition. More specifically, the 7 repeat variant of a variable number of tandem repeats (VNTR) polymorphism in exon III of this gene is suggested to bear a higher risk for ADHD. In the present study, we investigated the role of this polymorphism in the modulation of neurophysiological correlates of response inhibition (Go/Nogo task) in a healthy, high-functioning sample. Results Homozygous 7 repeat carriers showed a tendency for more accurate behavior in the Go/Nogo task compared to homozygous 4 repeat carriers. Moreover, 7 repeat carriers presented an increased nogo-related theta band response together with a reduced go-related beta decrease. Conclusions These data point to improved cognitive functions and prefrontal control in the 7 repeat carriers, probably due to the D4 receptor's modulatory role in prefrontal areas. The results are discussed with respect to previous behavioral data on this polymorphism and animal studies on the impact of the D4 receptor on cognitive functions.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/56825
url https://hdl.handle.net/2445/56825
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1186/1471-2202-10-150; http://dx.doi.org/10.1186/1471-2202-10-150
BMC Neuroscience, 2009, vol. 10, num. 150
http://dx.doi.org/10.1186/1471-2202-10-150
dc.rights.none.fl_str_mv cc-by (c) Krämer, UM. et al., 2009
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Krämer, UM. et al., 2009
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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