Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients

Introducción: Early published series suggest that most renal transplant recipients remain at high risk of SARS-CoV-2 infection due to poor humoral response after vaccination. The aim was to study the occurrence of adverse events after two doses of mRNA-1273 vaccine in a population of renal transplan...

Descripción completa

Detalles Bibliográficos
Autores: Gimeno Hernán, Verónica, Peix Jiménez, Belén, Pérez Flores, Isabel María, Aiffil Meneses, Arrianne, Ortuño Soriano, Ismael, Sánchez Fructuoso, Ana Isabel
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/118880
Acceso en línea:https://hdl.handle.net/20.500.14352/118880
Access Level:acceso abierto
Palabra clave:61
Renal transplantation
mRNA-1273 vaccine
SARS-CoV-2 adverse reactions
Ciencias Biomédicas
3299 Otras Especialidades Médicas
id ES_bfd463e32d49498ef4db6ed23f2b72ab
oai_identifier_str oai:docta.ucm.es:20.500.14352/118880
network_acronym_str ES
network_name_str España
repository_id_str
spelling Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipientsGimeno Hernán, VerónicaPeix Jiménez, BelénPérez Flores, Isabel MaríaAiffil Meneses, ArrianneOrtuño Soriano, IsmaelSánchez Fructuoso, Ana Isabel61Renal transplantationmRNA-1273 vaccineSARS-CoV-2 adverse reactionsCiencias Biomédicas3299 Otras Especialidades MédicasIntroducción: Early published series suggest that most renal transplant recipients remain at high risk of SARS-CoV-2 infection due to poor humoral response after vaccination. The aim was to study the occurrence of adverse events after two doses of mRNA-1273 vaccine in a population of renal transplant recipients. Material and Method: Analytical, observational, and prospective study. Subjects were injected with two doses of mRNA-1273 vaccine against SARS-CoV-2 according to the schedule established by the laboratory. After injection of each dose, and up to 72 hours later, participants recorded local and/or systemic symptoms and their intensity. Results: 187 patients were included. Eighteen percent of them became infected with SARS-CoV-2 in the pre-vaccination period or between the 1st and 2nd dose. The incidence of adverse events was 91.2%. Of these, the incidence of local (62%) was higher than that of systemic (55%). Past infection was a risk factor for the occurrence of local adverse events after vaccination (OR= 2.4; p=0.045). The same association was detected for systemic adverse events, which were more frequent among those who had passed the disease (OR=3.83; p=0.003). Conclusions: The mRNA-1273 vaccine does not appear to cause serious side effects. The incidence of local and systemic adverse events was higher in those patients with past disease.Sociedad Espanola de Enfermeria NefrologicaUniversidad Complutense de Madrid20242024-06-3020242024-06-30journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/118880reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1188802026-06-02T12:44:21Z
dc.title.none.fl_str_mv Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
title Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
spellingShingle Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
Gimeno Hernán, Verónica
61
Renal transplantation
mRNA-1273 vaccine
SARS-CoV-2 adverse reactions
Ciencias Biomédicas
3299 Otras Especialidades Médicas
title_short Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
title_full Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
title_fullStr Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
title_full_unstemmed Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
title_sort Incidence of adverse events of the Covid-19 vaccine in a population of kidney transplant recipients
dc.creator.none.fl_str_mv Gimeno Hernán, Verónica
Peix Jiménez, Belén
Pérez Flores, Isabel María
Aiffil Meneses, Arrianne
Ortuño Soriano, Ismael
Sánchez Fructuoso, Ana Isabel
author Gimeno Hernán, Verónica
author_facet Gimeno Hernán, Verónica
Peix Jiménez, Belén
Pérez Flores, Isabel María
Aiffil Meneses, Arrianne
Ortuño Soriano, Ismael
Sánchez Fructuoso, Ana Isabel
author_role author
author2 Peix Jiménez, Belén
Pérez Flores, Isabel María
Aiffil Meneses, Arrianne
Ortuño Soriano, Ismael
Sánchez Fructuoso, Ana Isabel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 61
Renal transplantation
mRNA-1273 vaccine
SARS-CoV-2 adverse reactions
Ciencias Biomédicas
3299 Otras Especialidades Médicas
topic 61
Renal transplantation
mRNA-1273 vaccine
SARS-CoV-2 adverse reactions
Ciencias Biomédicas
3299 Otras Especialidades Médicas
description Introducción: Early published series suggest that most renal transplant recipients remain at high risk of SARS-CoV-2 infection due to poor humoral response after vaccination. The aim was to study the occurrence of adverse events after two doses of mRNA-1273 vaccine in a population of renal transplant recipients. Material and Method: Analytical, observational, and prospective study. Subjects were injected with two doses of mRNA-1273 vaccine against SARS-CoV-2 according to the schedule established by the laboratory. After injection of each dose, and up to 72 hours later, participants recorded local and/or systemic symptoms and their intensity. Results: 187 patients were included. Eighteen percent of them became infected with SARS-CoV-2 in the pre-vaccination period or between the 1st and 2nd dose. The incidence of adverse events was 91.2%. Of these, the incidence of local (62%) was higher than that of systemic (55%). Past infection was a risk factor for the occurrence of local adverse events after vaccination (OR= 2.4; p=0.045). The same association was detected for systemic adverse events, which were more frequent among those who had passed the disease (OR=3.83; p=0.003). Conclusions: The mRNA-1273 vaccine does not appear to cause serious side effects. The incidence of local and systemic adverse events was higher in those patients with past disease.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-06-30
2024
2024-06-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/118880
url https://hdl.handle.net/20.500.14352/118880
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Espanola de Enfermeria Nefrologica
publisher.none.fl_str_mv Sociedad Espanola de Enfermeria Nefrologica
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418425255723008
score 15,812455

Similares en LA Referencia