Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD

Objective: to compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD). Methods: clinical features and VPSG measures were evaluated in 110 consecutive nondemented...

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Detalhes bibliográficos
Autores: Iranzo, Alex, Santamaria Cano, Joan, Rye, D. B., Valldeoriola Serra, Francesc, Martí Domènech, Ma. Josep, Muñoz, E., Vilaseca González, Isabel, Tolosa, Eduardo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/157417
Acesso em linha:https://hdl.handle.net/2445/157417
Access Level:acceso abierto
Palavra-chave:Cervell
Malaltia de Parkinson
Trastorns del son
Etiologia
Brain
Parkinson's disease
Sleep disorders
Etiology
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spelling Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PDIranzo, AlexSantamaria Cano, JoanRye, D. B.Valldeoriola Serra, FrancescMartí Domènech, Ma. JosepMuñoz, E.Vilaseca González, IsabelTolosa, EduardoCervellMalaltia de ParkinsonTrastorns del sonEtiologiaBrainParkinson's diseaseSleep disordersEtiologyObjective: to compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD). Methods: clinical features and VPSG measures were evaluated in 110 consecutive nondemented subjects (26 MSA, 45 PD, and 39 idiopathic RBD) free of psychoactive medications referred for suspected RBD to our sleep unit over a 5-year period, with extended follow-up (mean 26.9 +/- 21.3 months). Results: across the three groups studied, logistic regression analysis demonstrated that there were no differences in the quality of RBD symptoms (e.g., nature of unpleasant dream recall or behaviors witnessed by bed partners), most PSG variables, abnormal behaviors captured by VPSG, and clinical response to clonazepam. When compared to subjects with PD, however, patients with MSA had a significantly shorter duration of disease, a higher REM sleep without atonia percentage, a greater periodic leg movement index, and less total sleep time. Subjects with idiopathic RBD, as compared to those with either MSA or PD, were more often male, had greater self-reported clinical RBD severity, and were more often aware of their abnormal sleep behaviors. Conclusions: REM sleep behavior disorder (RBD)-related symptoms and neurophysiologic features are qualitatively similar in RBD subjects with the idiopathic form, multiple system atrophy (MSA), and Parkinson disease (PD). Polysomnographic abnormalities associated with RBD in the setting of MSA are greater than in PD, suggesting a more severe dysfunction in the structures that modulate REM sleep.Lippincott, Williams & Wilkins. Wolters Kluwer Health2020202020052020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/157417Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1212/01.wnl.0000168864.97813.e0Neurology, 2005, vol. 65, num. 2, p. 247-252https://doi.org/10.1212/01.wnl.0000168864.97813.e0(c) American Academy of Neurology, 2005info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1574172026-05-29T05:05:01Z
dc.title.none.fl_str_mv Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
title Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
spellingShingle Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
Iranzo, Alex
Cervell
Malaltia de Parkinson
Trastorns del son
Etiologia
Brain
Parkinson's disease
Sleep disorders
Etiology
title_short Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
title_full Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
title_fullStr Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
title_full_unstemmed Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
title_sort Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
dc.creator.none.fl_str_mv Iranzo, Alex
Santamaria Cano, Joan
Rye, D. B.
Valldeoriola Serra, Francesc
Martí Domènech, Ma. Josep
Muñoz, E.
Vilaseca González, Isabel
Tolosa, Eduardo
author Iranzo, Alex
author_facet Iranzo, Alex
Santamaria Cano, Joan
Rye, D. B.
Valldeoriola Serra, Francesc
Martí Domènech, Ma. Josep
Muñoz, E.
Vilaseca González, Isabel
Tolosa, Eduardo
author_role author
author2 Santamaria Cano, Joan
Rye, D. B.
Valldeoriola Serra, Francesc
Martí Domènech, Ma. Josep
Muñoz, E.
Vilaseca González, Isabel
Tolosa, Eduardo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cervell
Malaltia de Parkinson
Trastorns del son
Etiologia
Brain
Parkinson's disease
Sleep disorders
Etiology
topic Cervell
Malaltia de Parkinson
Trastorns del son
Etiologia
Brain
Parkinson's disease
Sleep disorders
Etiology
description Objective: to compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD). Methods: clinical features and VPSG measures were evaluated in 110 consecutive nondemented subjects (26 MSA, 45 PD, and 39 idiopathic RBD) free of psychoactive medications referred for suspected RBD to our sleep unit over a 5-year period, with extended follow-up (mean 26.9 +/- 21.3 months). Results: across the three groups studied, logistic regression analysis demonstrated that there were no differences in the quality of RBD symptoms (e.g., nature of unpleasant dream recall or behaviors witnessed by bed partners), most PSG variables, abnormal behaviors captured by VPSG, and clinical response to clonazepam. When compared to subjects with PD, however, patients with MSA had a significantly shorter duration of disease, a higher REM sleep without atonia percentage, a greater periodic leg movement index, and less total sleep time. Subjects with idiopathic RBD, as compared to those with either MSA or PD, were more often male, had greater self-reported clinical RBD severity, and were more often aware of their abnormal sleep behaviors. Conclusions: REM sleep behavior disorder (RBD)-related symptoms and neurophysiologic features are qualitatively similar in RBD subjects with the idiopathic form, multiple system atrophy (MSA), and Parkinson disease (PD). Polysomnographic abnormalities associated with RBD in the setting of MSA are greater than in PD, suggesting a more severe dysfunction in the structures that modulate REM sleep.
publishDate 2005
dc.date.none.fl_str_mv 2005
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/157417
url https://hdl.handle.net/2445/157417
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1212/01.wnl.0000168864.97813.e0
Neurology, 2005, vol. 65, num. 2, p. 247-252
https://doi.org/10.1212/01.wnl.0000168864.97813.e0
dc.rights.none.fl_str_mv (c) American Academy of Neurology, 2005
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Academy of Neurology, 2005
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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