Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010

In Catalonia, pertussis outbreaks must be reported to the Department of Health. This study analyzed pertussis outbreaks between 1997 and 2010 in general and according to the characteristics of the index cases. The outbreak rate, hospitalization rate and incidence of associated cases and their 95%CI...

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Detalles Bibliográficos
Autores: Crespo, I, Broner, S, Soldevila, N, Martinez, A, Godoy, P, Sala-Farre, MR, Company, M, Rius, C, Dominguez, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p14655
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14655
Access Level:acceso abierto
Palabra clave:pertussis
hospitalization
surveillance
whole cell pertussis vaccine
acellular pertussis vaccine
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spelling Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010Crespo, IBroner, SSoldevila, NMartinez, AGodoy, PSala-Farre, MRCompany, MRius, CDominguez, Apertussishospitalizationsurveillancewhole cell pertussis vaccineacellular pertussis vaccineIn Catalonia, pertussis outbreaks must be reported to the Department of Health. This study analyzed pertussis outbreaks between 1997 and 2010 in general and according to the characteristics of the index cases. The outbreak rate, hospitalization rate and incidence of associated cases and their 95%CI were calculated. Index cases were classified in two groups according to age (< 15 years and 15 years) and the vaccine type received: whole cell vaccine (DTwP) or acellular vaccine (DTaP). During the study period, 230 outbreaks were reported. The outbreak rate was 2.43 x 10(-6) persons-year, and outbreaks ranged from 2 to 32 cases, with a median duration of 18 days. There were 771 associated cases, with an incidence rate of 0.8 x 10(-5) persons-year. After classifying outbreaks according to the age of the index case, 126 outbreaks (1.3 x 10(-6) persons-year) had an index case aged < 15 y and 87 (0.87 x 10(-6) person-year) had an index case aged 15 y (RR = 1.44, 95%CI 1.10-1.90; P = 0.007). Between 2003 and 2010, after the introduction of the acellular vaccine, the index case was vaccinated with DTwP vaccine in 25 outbreaks (0.43 x 10(-6) persons-year) and with DTaP vaccine in 32 outbreaks (0.55 x 10(-6) person-year) (RR = 0.78, 95%CI 0.46-1.31; P = 0.35). Of cases, 37.2% were correctly vaccinated, suggesting waning immunity of pertussis vaccine protection and endogenous circulation of pertussis. A greater number of outbreaks had an index case aged < 15 y. No changes in the disease incidence, associated cases and hospitalization rate were observed after the introduction of DTaP.TAYLOR & FRANCIS INC2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14655Human Vaccines & ImmunotherapeuticsISSN: 21645515ISSNe: 2164554Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p146552026-06-14T12:41:47Z
dc.title.none.fl_str_mv Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
title Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
spellingShingle Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
Crespo, I
pertussis
hospitalization
surveillance
whole cell pertussis vaccine
acellular pertussis vaccine
title_short Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
title_full Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
title_fullStr Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
title_full_unstemmed Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
title_sort Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
dc.creator.none.fl_str_mv Crespo, I
Broner, S
Soldevila, N
Martinez, A
Godoy, P
Sala-Farre, MR
Company, M
Rius, C
Dominguez, A
author Crespo, I
author_facet Crespo, I
Broner, S
Soldevila, N
Martinez, A
Godoy, P
Sala-Farre, MR
Company, M
Rius, C
Dominguez, A
author_role author
author2 Broner, S
Soldevila, N
Martinez, A
Godoy, P
Sala-Farre, MR
Company, M
Rius, C
Dominguez, A
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv pertussis
hospitalization
surveillance
whole cell pertussis vaccine
acellular pertussis vaccine
topic pertussis
hospitalization
surveillance
whole cell pertussis vaccine
acellular pertussis vaccine
description In Catalonia, pertussis outbreaks must be reported to the Department of Health. This study analyzed pertussis outbreaks between 1997 and 2010 in general and according to the characteristics of the index cases. The outbreak rate, hospitalization rate and incidence of associated cases and their 95%CI were calculated. Index cases were classified in two groups according to age (< 15 years and 15 years) and the vaccine type received: whole cell vaccine (DTwP) or acellular vaccine (DTaP). During the study period, 230 outbreaks were reported. The outbreak rate was 2.43 x 10(-6) persons-year, and outbreaks ranged from 2 to 32 cases, with a median duration of 18 days. There were 771 associated cases, with an incidence rate of 0.8 x 10(-5) persons-year. After classifying outbreaks according to the age of the index case, 126 outbreaks (1.3 x 10(-6) persons-year) had an index case aged < 15 y and 87 (0.87 x 10(-6) person-year) had an index case aged 15 y (RR = 1.44, 95%CI 1.10-1.90; P = 0.007). Between 2003 and 2010, after the introduction of the acellular vaccine, the index case was vaccinated with DTwP vaccine in 25 outbreaks (0.43 x 10(-6) persons-year) and with DTaP vaccine in 32 outbreaks (0.55 x 10(-6) person-year) (RR = 0.78, 95%CI 0.46-1.31; P = 0.35). Of cases, 37.2% were correctly vaccinated, suggesting waning immunity of pertussis vaccine protection and endogenous circulation of pertussis. A greater number of outbreaks had an index case aged < 15 y. No changes in the disease incidence, associated cases and hospitalization rate were observed after the introduction of DTaP.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14655
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14655
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS INC
publisher.none.fl_str_mv TAYLOR & FRANCIS INC
dc.source.none.fl_str_mv Human Vaccines & Immunotherapeutics
ISSN: 21645515
ISSNe: 2164554X
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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