Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics

Microfluidic systems, especially those using capillary forces, have recently attracted considerable interest due to their potential to facilitate passive fluid management in portable diagnostic devices and point-of-care settings. These systems utilize capillary forces to autonomously regulate fluid...

Full description

Bibliographic Details
Authors: López Martínez, Joan Antoni|||0000-0002-0082-9770, Casals Terré, Jasmina|||0000-0002-1368-3950
Format: article
Publication Date:2025
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/423124
Online Access:https://hdl.handle.net/2117/423124
https://dx.doi.org/10.3389/frlct.2025.1502127
Access Level:Open access
Keyword:Microfluidics
Capillary valves
Capillary pumps
Biochemical assays
POC diagnostics
Àrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluids
id ES_bfb5ca2b7521ac5b8a968c7bae773362
oai_identifier_str oai:upcommons.upc.edu:2117/423124
network_acronym_str ES
network_name_str España
repository_id_str
spelling Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillaricsLópez Martínez, Joan Antoni|||0000-0002-0082-9770Casals Terré, Jasmina|||0000-0002-1368-3950MicrofluidicsCapillary valvesCapillary pumpsBiochemical assaysPOC diagnosticsÀrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluidsMicrofluidic systems, especially those using capillary forces, have recently attracted considerable interest due to their potential to facilitate passive fluid management in portable diagnostic devices and point-of-care settings. These systems utilize capillary forces to autonomously regulate fluid flow, eliminating the requirement for external power and providing a more straightforward and economical option compared to active microfluidic systems. This review examines the fundamental concepts of capillary-driven microfluidics, emphasizing significant progress in the design of capillary pumps and valves, as well as the influence of surface tension, wettability, and the geometrical configurations of microchannels on the enhancement of fluid dynamics. Furthermore, the review explores other configurations, such as porous and solid substrates, to illustrate their potential for healthcare and biochemical applications. Moreover, the challenges related to managing flow rates and enhancing the reproducibility of devices are addressed, alongside recent innovations designed to overcome these challenges. Capillary systems offer an effective and reliable foundation for developing miniaturized diagnostic instruments, which hold significant potential across various domains, including biological research and environmental monitoringFrontiers Media SA20252025-01-2820252025-01-31journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/423124https://dx.doi.org/10.3389/frlct.2025.1502127reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4231242026-05-27T15:37:01Z
dc.title.none.fl_str_mv Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
title Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
spellingShingle Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
López Martínez, Joan Antoni|||0000-0002-0082-9770
Microfluidics
Capillary valves
Capillary pumps
Biochemical assays
POC diagnostics
Àrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluids
title_short Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
title_full Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
title_fullStr Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
title_full_unstemmed Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
title_sort Capillary microfluidics for diagnostic applications: fundamentals, mechanisms, and capillarics
dc.creator.none.fl_str_mv López Martínez, Joan Antoni|||0000-0002-0082-9770
Casals Terré, Jasmina|||0000-0002-1368-3950
author López Martínez, Joan Antoni|||0000-0002-0082-9770
author_facet López Martínez, Joan Antoni|||0000-0002-0082-9770
Casals Terré, Jasmina|||0000-0002-1368-3950
author_role author
author2 Casals Terré, Jasmina|||0000-0002-1368-3950
author2_role author
dc.subject.none.fl_str_mv Microfluidics
Capillary valves
Capillary pumps
Biochemical assays
POC diagnostics
Àrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluids
topic Microfluidics
Capillary valves
Capillary pumps
Biochemical assays
POC diagnostics
Àrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluids
description Microfluidic systems, especially those using capillary forces, have recently attracted considerable interest due to their potential to facilitate passive fluid management in portable diagnostic devices and point-of-care settings. These systems utilize capillary forces to autonomously regulate fluid flow, eliminating the requirement for external power and providing a more straightforward and economical option compared to active microfluidic systems. This review examines the fundamental concepts of capillary-driven microfluidics, emphasizing significant progress in the design of capillary pumps and valves, as well as the influence of surface tension, wettability, and the geometrical configurations of microchannels on the enhancement of fluid dynamics. Furthermore, the review explores other configurations, such as porous and solid substrates, to illustrate their potential for healthcare and biochemical applications. Moreover, the challenges related to managing flow rates and enhancing the reproducibility of devices are addressed, alongside recent innovations designed to overcome these challenges. Capillary systems offer an effective and reliable foundation for developing miniaturized diagnostic instruments, which hold significant potential across various domains, including biological research and environmental monitoring
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-28
2025
2025-01-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/423124
https://dx.doi.org/10.3389/frlct.2025.1502127
url https://hdl.handle.net/2117/423124
https://dx.doi.org/10.3389/frlct.2025.1502127
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418414754234368
score 15.812429

Similar Items