Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew
The main aim of the present study was to determine if synapses from the exceptionally small brain of the Etruscan shrew show any peculiarities compared to the much larger human brain. We analyzed the cortical synaptic density and a variety of structural characteristics of 7,239 3D reconstructed syna...
| Autores: | , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/343098 |
| Acesso em linha: | http://hdl.handle.net/10261/343098 |
| Access Level: | acceso abierto |
| Palavra-chave: | FIB-SEM brain cerebral cortex Electron microscopy synaptic junction ultrastructure. |
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Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrewAlonso-Nanclares, LidiaRodríguez Sánchez, José RodrigoMerchán-Pérez, ÁngelGonzález-Soriano, JuncalPlaza-Alonso, SergioCano-Astorga, NicolásNaumann, Robert K.Brecht, MichaelDeFelipe, JavierFIB-SEMbraincerebral cortexElectron microscopysynaptic junctionultrastructure.The main aim of the present study was to determine if synapses from the exceptionally small brain of the Etruscan shrew show any peculiarities compared to the much larger human brain. We analyzed the cortical synaptic density and a variety of structural characteristics of 7,239 3D reconstructed synapses, using using Focused Ion Beam/Scanning Electron Microscopy (FIB/SEM). We found that some of the general synaptic characteristics are remarkably similar to those found in the human cerebral cortex. However, the cortical volume of the human brain is about 50,000 times larger than the cortical volume of the Etruscan shrew, while the total number of cortical synapses in human is only 20,000 times the number of synapses in the shrew, and synaptic junctions are 35% smaller in the Etruscan shrew. Thus, the differences in the number and size of synapses cannot be attributed to a brain size scaling effect but rather to adaptations of synaptic circuits to particular functions.This work was supported by the following Grants: PGC2018-094307-B-I00 (to J.D.) funded by MCIN/AEI/10.13039/501100011033 and the Interdisciplinary Platform Cajal Blue Brain (CSIC, Spain). Research Fellowships funded by MCIN/AEI/10.13039/501100011033 for N.C.-A. (PRE2019-089228) and S.P.-A. (FPU19/00007).We would like to thank L. Valdés and C. Álvarez for technical assistance, and Nick Guthrie for his comments and excellent editorial assistance.Peer reviewedJohn Wiley & SonsMinisterio de Ciencia e Innovación (España)Cajal Blue BrainConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420232024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/343098reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094307-B-I00info:eu-repo/grantAgreement/AEI//PRE2019-089228http://dx.doi.org/10.1002/cne.25432Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3430982026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| title |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| spellingShingle |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew Alonso-Nanclares, Lidia FIB-SEM brain cerebral cortex Electron microscopy synaptic junction ultrastructure. |
| title_short |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| title_full |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| title_fullStr |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| title_full_unstemmed |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| title_sort |
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew |
| dc.creator.none.fl_str_mv |
Alonso-Nanclares, Lidia Rodríguez Sánchez, José Rodrigo Merchán-Pérez, Ángel González-Soriano, Juncal Plaza-Alonso, Sergio Cano-Astorga, Nicolás Naumann, Robert K. Brecht, Michael DeFelipe, Javier |
| author |
Alonso-Nanclares, Lidia |
| author_facet |
Alonso-Nanclares, Lidia Rodríguez Sánchez, José Rodrigo Merchán-Pérez, Ángel González-Soriano, Juncal Plaza-Alonso, Sergio Cano-Astorga, Nicolás Naumann, Robert K. Brecht, Michael DeFelipe, Javier |
| author_role |
author |
| author2 |
Rodríguez Sánchez, José Rodrigo Merchán-Pérez, Ángel González-Soriano, Juncal Plaza-Alonso, Sergio Cano-Astorga, Nicolás Naumann, Robert K. Brecht, Michael DeFelipe, Javier |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia e Innovación (España) Cajal Blue Brain Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
FIB-SEM brain cerebral cortex Electron microscopy synaptic junction ultrastructure. |
| topic |
FIB-SEM brain cerebral cortex Electron microscopy synaptic junction ultrastructure. |
| description |
The main aim of the present study was to determine if synapses from the exceptionally small brain of the Etruscan shrew show any peculiarities compared to the much larger human brain. We analyzed the cortical synaptic density and a variety of structural characteristics of 7,239 3D reconstructed synapses, using using Focused Ion Beam/Scanning Electron Microscopy (FIB/SEM). We found that some of the general synaptic characteristics are remarkably similar to those found in the human cerebral cortex. However, the cortical volume of the human brain is about 50,000 times larger than the cortical volume of the Etruscan shrew, while the total number of cortical synapses in human is only 20,000 times the number of synapses in the shrew, and synaptic junctions are 35% smaller in the Etruscan shrew. Thus, the differences in the number and size of synapses cannot be attributed to a brain size scaling effect but rather to adaptations of synaptic circuits to particular functions. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/343098 |
| url |
http://hdl.handle.net/10261/343098 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094307-B-I00 info:eu-repo/grantAgreement/AEI//PRE2019-089228 http://dx.doi.org/10.1002/cne.25432 Sí |
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info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
John Wiley & Sons |
| publisher.none.fl_str_mv |
John Wiley & Sons |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869418414117748736 |
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15.812429 |