Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue
Omomyc; Mass spectrometry; Protein therapeutics
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/9181 |
| Acceso en línea: | https://hdl.handle.net/11351/9181 |
| Access Level: | acceso abierto |
| Palabra clave: | Mama - Càncer - Tractament Proteïnes - Ús terapèutic CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins Other subheadings::Other subheadings::Other subheadings::/pharmacokinetics DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::/therapy COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias::proteínas oncogénicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacocinética ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::/terapia |
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Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor TissueMartínez Martín, SandraCastillo Cano, VirginiaMassó Vallés, DanielLópez-Estévez, SergioThabussot, HugoBeaulieu, Marie-EveSoucek, LauraForadada Felip, LaiaKaur, JastrinjanSerrano del Pozo, ErikaMama - Càncer - TractamentProteïnes - Ús terapèuticCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene ProteinsOther subheadings::Other subheadings::Other subheadings::/pharmacokineticsDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::/therapyCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias::proteínas oncogénicasOtros calificadores::Otros calificadores::Otros calificadores::/farmacocinéticaENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::/terapiaOmomyc; Mass spectrometry; Protein therapeuticsOmomyc; Espectrometría de masas; Terapéutica de proteínasOmomyc; Espectrometria de masses; Terapèutica de proteïnesMYC is an oncoprotein causally involved in the majority of human cancers and a most wanted target for cancer treatment. Omomyc is the best-characterized MYC dominant negative to date. In the last years, it has been developed into a therapeutic miniprotein for solid tumor treatment and recently reached clinical stage. However, since the in vivo stability of therapeutic proteins, especially within the tumor vicinity, can be affected by proteolytic degradation, the perception of Omomyc as a valid therapeutic agent has been often questioned. In this study, we used a mass spectrometry approach to evaluate the stability of Omomyc in tumor biopsies from murine xenografts following its intravenous administration. Our data strongly support that the integrity of the functional domains of Omomyc (DNA binding and dimerization region) remains preserved in the tumor tissue for at least 72 hours following administration and that the protein shows superior pharmacokinetics in the tumor compartment compared with blood serum.This research has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 872212 and from the Ministerio de Ciencia e Innovacion under grant no. RTC2019-007067-1.MDPIInstitut Català de la Salut[Beaulieu ME, Martínez-Martín S, Castillo Cano V, Massó-Vallés D, Foradada Felip L, López-Estévez S, Thabussot H] Peptomyc S.L., Barcelona, Spain. [Kaur J, Serrano del Pozo E] Preclinical & Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Soucek L] Peptomyc S.L., Barcelona, Spain. Preclinical & Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9181Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésCancers;15(3)https://doi.org/10.3390/cancers15030826info:eu-repo/grantAgreement/EC/H2020/872212info:eu-repo/grantAgreement/ES/PE2017-2020/RTC2019-007067-1Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/91812026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| title |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| spellingShingle |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue Martínez Martín, Sandra Mama - Càncer - Tractament Proteïnes - Ús terapèutic CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins Other subheadings::Other subheadings::Other subheadings::/pharmacokinetics DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::/therapy COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias::proteínas oncogénicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacocinética ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::/terapia |
| title_short |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| title_full |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| title_fullStr |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| title_full_unstemmed |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| title_sort |
Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue |
| dc.creator.none.fl_str_mv |
Martínez Martín, Sandra Castillo Cano, Virginia Massó Vallés, Daniel López-Estévez, Sergio Thabussot, Hugo Beaulieu, Marie-Eve Soucek, Laura Foradada Felip, Laia Kaur, Jastrinjan Serrano del Pozo, Erika |
| author |
Martínez Martín, Sandra |
| author_facet |
Martínez Martín, Sandra Castillo Cano, Virginia Massó Vallés, Daniel López-Estévez, Sergio Thabussot, Hugo Beaulieu, Marie-Eve Soucek, Laura Foradada Felip, Laia Kaur, Jastrinjan Serrano del Pozo, Erika |
| author_role |
author |
| author2 |
Castillo Cano, Virginia Massó Vallés, Daniel López-Estévez, Sergio Thabussot, Hugo Beaulieu, Marie-Eve Soucek, Laura Foradada Felip, Laia Kaur, Jastrinjan Serrano del Pozo, Erika |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Beaulieu ME, Martínez-Martín S, Castillo Cano V, Massó-Vallés D, Foradada Felip L, López-Estévez S, Thabussot H] Peptomyc S.L., Barcelona, Spain. [Kaur J, Serrano del Pozo E] Preclinical & Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Soucek L] Peptomyc S.L., Barcelona, Spain. Preclinical & Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Mama - Càncer - Tractament Proteïnes - Ús terapèutic CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins Other subheadings::Other subheadings::Other subheadings::/pharmacokinetics DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::/therapy COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias::proteínas oncogénicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacocinética ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::/terapia |
| topic |
Mama - Càncer - Tractament Proteïnes - Ús terapèutic CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins Other subheadings::Other subheadings::Other subheadings::/pharmacokinetics DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::/therapy COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de neoplasias::proteínas oncogénicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacocinética ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::/terapia |
| description |
Omomyc; Mass spectrometry; Protein therapeutics |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11351/9181 |
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https://hdl.handle.net/11351/9181 |
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Inglés |
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Inglés |
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Cancers;15(3) https://doi.org/10.3390/cancers15030826 info:eu-repo/grantAgreement/EC/H2020/872212 info:eu-repo/grantAgreement/ES/PE2017-2020/RTC2019-007067-1 |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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