Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?

Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data Sys...

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Autores: Morote Robles, Juan|||0000-0002-2168-323X, Celma, Ana|||0000-0002-3128-3811, Semidey, M. Eugenia, Antolín, Andreu|||0000-0001-6973-4246, Miró, Berta|||0000-0001-6049-8697, Méndez Fernández, Olga|||0000-0003-4237-330X, Trilla Herrera, Enrique|||0000-0001-9401-0872
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:307932
Acesso em linha:https://ddd.uab.cat/record/307932
https://dx.doi.org/urn:doi:10.3390/cancers17010053
Access Level:acceso abierto
Palavra-chave:Prostate cancer
Inflammation
Prostatitis
Magnetic resonance imaging
Prostate biopsy
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spelling Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?Morote Robles, Juan|||0000-0002-2168-323XCelma, Ana|||0000-0002-3128-3811Semidey, M. EugeniaAntolín, Andreu|||0000-0001-6973-4246Miró, Berta|||0000-0001-6049-8697Méndez Fernández, Olga|||0000-0003-4237-330XTrilla Herrera, Enrique|||0000-0001-9401-0872Prostate cancerInflammationProstatitisMagnetic resonance imagingProstate biopsyBackground. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69.6%, compared to 48.1% in those with PCa (p < 0.001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68.6% to 71.2% across the PI-RADS categories (p = 0.870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66.7%, compared to 42.7% in those with significant PCa (grade group 2 to 5; p = 0.027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0.326 (95% CI 0.196-0.541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0.398 (95% CI 0.268-0.590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/307932https://dx.doi.org/urn:doi:10.3390/cancers17010053reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01666open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3079322026-06-06T12:50:31Z
dc.title.none.fl_str_mv Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
title Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
spellingShingle Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
Morote Robles, Juan|||0000-0002-2168-323X
Prostate cancer
Inflammation
Prostatitis
Magnetic resonance imaging
Prostate biopsy
title_short Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
title_full Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
title_fullStr Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
title_full_unstemmed Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
title_sort Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
dc.creator.none.fl_str_mv Morote Robles, Juan|||0000-0002-2168-323X
Celma, Ana|||0000-0002-3128-3811
Semidey, M. Eugenia
Antolín, Andreu|||0000-0001-6973-4246
Miró, Berta|||0000-0001-6049-8697
Méndez Fernández, Olga|||0000-0003-4237-330X
Trilla Herrera, Enrique|||0000-0001-9401-0872
author Morote Robles, Juan|||0000-0002-2168-323X
author_facet Morote Robles, Juan|||0000-0002-2168-323X
Celma, Ana|||0000-0002-3128-3811
Semidey, M. Eugenia
Antolín, Andreu|||0000-0001-6973-4246
Miró, Berta|||0000-0001-6049-8697
Méndez Fernández, Olga|||0000-0003-4237-330X
Trilla Herrera, Enrique|||0000-0001-9401-0872
author_role author
author2 Celma, Ana|||0000-0002-3128-3811
Semidey, M. Eugenia
Antolín, Andreu|||0000-0001-6973-4246
Miró, Berta|||0000-0001-6049-8697
Méndez Fernández, Olga|||0000-0003-4237-330X
Trilla Herrera, Enrique|||0000-0001-9401-0872
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Prostate cancer
Inflammation
Prostatitis
Magnetic resonance imaging
Prostate biopsy
topic Prostate cancer
Inflammation
Prostatitis
Magnetic resonance imaging
Prostate biopsy
description Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69.6%, compared to 48.1% in those with PCa (p < 0.001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68.6% to 71.2% across the PI-RADS categories (p = 0.870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66.7%, compared to 42.7% in those with significant PCa (grade group 2 to 5; p = 0.027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0.326 (95% CI 0.196-0.541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0.398 (95% CI 0.268-0.590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/307932
https://dx.doi.org/urn:doi:10.3390/cancers17010053
url https://ddd.uab.cat/record/307932
https://dx.doi.org/urn:doi:10.3390/cancers17010053
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01666
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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