Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population

Introduction: NAFLD has emerged as a significant public health concern, with its prevalence increasing globally. Emphasizing the complex relationship between dietary patterns and epigenetic modifications such as DNA-methylation or miRNA expression can exert positive impact on preventing and managing...

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Author: Martín Barraza, Josefina Inés
Format: master thesis
Publication Date:2024
Country:España
Institution:Universitat Oberta de Catalunya (UOC)
Repository:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/151203
Online Access:http://hdl.handle.net/10609/151203
Access Level:Open access
Keyword:dietary pattern
epigenetic
NAFLD
nutrition
DNA-methylation
miRNA
patrón dietético
nutrición
epigenética
metilación del ADN
miARN
Liver -- Diseases -- FMDP
Fetge -- Malalties -- TFM
id ES_bf7960c33d4e7cf58c843f80e921c9ad
oai_identifier_str oai:openaccess.uoc.edu:10609/151203
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
title Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
spellingShingle Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
Martín Barraza, Josefina Inés
dietary pattern
epigenetic
NAFLD
nutrition
DNA-methylation
miRNA
patrón dietético
nutrición
epigenética
metilación del ADN
miARN
NAFLD
Liver -- Diseases -- FMDP
Fetge -- Malalties -- TFM
title_short Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
title_full Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
title_fullStr Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
title_full_unstemmed Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
title_sort Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
dc.creator.none.fl_str_mv Martín Barraza, Josefina Inés
author Martín Barraza, Josefina Inés
author_facet Martín Barraza, Josefina Inés
author_role author
dc.contributor.none.fl_str_mv Bars-Cortina, David
dc.subject.none.fl_str_mv dietary pattern
epigenetic
NAFLD
nutrition
DNA-methylation
miRNA
patrón dietético
nutrición
epigenética
metilación del ADN
miARN
NAFLD
Liver -- Diseases -- FMDP
Fetge -- Malalties -- TFM
topic dietary pattern
epigenetic
NAFLD
nutrition
DNA-methylation
miRNA
patrón dietético
nutrición
epigenética
metilación del ADN
miARN
NAFLD
Liver -- Diseases -- FMDP
Fetge -- Malalties -- TFM
description Introduction: NAFLD has emerged as a significant public health concern, with its prevalence increasing globally. Emphasizing the complex relationship between dietary patterns and epigenetic modifications such as DNA-methylation or miRNA expression can exert positive impact on preventing and managing metabolic disorders, including NAFLD within the 2030 SDG. This review aims to evaluate the influence of dietary patterns on hepatic epigenetic gene modulation and provide dietary recommendations for the prevention and management of NAFLD in the general population. Methods: A comprehensive screening and eligibility criteria were applied to identify relevant articles focusing on the interplay between dietary regimens and epigenetic mechanisms, specifically concerning hepatic function in response to dietary intake or supplementation. A total of 11 articles were included in the ultimate analysis, encompassing studies evaluating epigenetic changes in NAFLD patients through modifications in dietary patterns o nutrient supplementation. Results: Collected data was organized based on the type of studies, categorizing them into evaluations of epigenetic changes in NAFLD patients by modifying dietary patterns or by the modification/supplementation of different types of nutrients. Conclusions: The study underscored the importance of considering dietary interventions in the management and prevention of NAFLD, shedding light on the potential of dietary patterns to influence hepatic epigenetic gene modulation. This review provides valuable insights into the role of dietary interventions in NAFLD and offers recommendations for the general population to mitigate the risk of developing this metabolic disorder.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10609/151203
url http://hdl.handle.net/10609/151203
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat Oberta de Catalunya (UOC)
publisher.none.fl_str_mv Universitat Oberta de Catalunya (UOC)
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418394341605376
spelling Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general populationMartín Barraza, Josefina Inésdietary patternepigeneticNAFLDnutritionDNA-methylationmiRNApatrón dietéticonutriciónepigenéticametilación del ADNmiARNNAFLDLiver -- Diseases -- FMDPFetge -- Malalties -- TFMIntroduction: NAFLD has emerged as a significant public health concern, with its prevalence increasing globally. Emphasizing the complex relationship between dietary patterns and epigenetic modifications such as DNA-methylation or miRNA expression can exert positive impact on preventing and managing metabolic disorders, including NAFLD within the 2030 SDG. This review aims to evaluate the influence of dietary patterns on hepatic epigenetic gene modulation and provide dietary recommendations for the prevention and management of NAFLD in the general population. Methods: A comprehensive screening and eligibility criteria were applied to identify relevant articles focusing on the interplay between dietary regimens and epigenetic mechanisms, specifically concerning hepatic function in response to dietary intake or supplementation. A total of 11 articles were included in the ultimate analysis, encompassing studies evaluating epigenetic changes in NAFLD patients through modifications in dietary patterns o nutrient supplementation. Results: Collected data was organized based on the type of studies, categorizing them into evaluations of epigenetic changes in NAFLD patients by modifying dietary patterns or by the modification/supplementation of different types of nutrients. Conclusions: The study underscored the importance of considering dietary interventions in the management and prevention of NAFLD, shedding light on the potential of dietary patterns to influence hepatic epigenetic gene modulation. This review provides valuable insights into the role of dietary interventions in NAFLD and offers recommendations for the general population to mitigate the risk of developing this metabolic disorder.Introducción: NAFLD se ha convertido en un importante problema de salud pública y su prevalencia está aumentando a nivel mundial. Hacer hincapié en la compleja relación entre los patrones dietéticos y las modificaciones epigenéticas, como la metilación del ADN o la expresión de miARNs, puede ejercer un impacto positivo en la prevención y el manejo de los trastornos metabólicos, incluida la NAFLD dentro de los ODS 2030. Esta revisión tiene como objetivo evaluar la influencia de los patrones dietéticos en la modulación epigenética de genes hepáticos y proporcionar recomendaciones dietéticas para la prevención y el tratamiento de la NAFLD en la población general. Métodos: Se aplicaron criterios integrales de selección y elegibilidad para identificar artículos relevantes que se centren en la interacción entre los regímenes dietéticos y los mecanismos epigenéticos, específicamente en relación con la función hepática en respuesta a la ingesta dietética o la suplementación. En el análisis final se incluyeron un total de 11 artículos, que abarcan estudios que evalúan los cambios epigenéticos en pacientes con NAFLD mediante modificaciones en los patrones dietéticos o suplementación de nutrientes. Resultados: Los datos recopilados se organizaron según el tipo de estudios, categorizándolos en evaluaciones de cambios epigenéticos en pacientes con NAFLD mediante la modificación de patrones dietéticos o mediante la modificación/suplementación de diferentes tipos de nutrientes. Conclusiones: El estudio subrayó la importancia de considerar intervenciones dietéticas en el tratamiento y la prevención de NAFLD, arrojando luz sobre el potencial de los patrones dietéticos para influir en la modulación epigenética del hígado. Esta revisión proporciona información valiosa sobre el papel de las intervenciones dietéticas en la NAFLD y ofrece recomendaciones para que la población general mitigue el riesgo de desarrollar este trastorno metabólico.Universitat Oberta de Catalunya (UOC)Bars-Cortina, David202420242024info:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfhttp://hdl.handle.net/10609/151203reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésCC BY-NC-NDhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1512032026-05-28T12:42:01Z
score 15,812429

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