CD117 expression in canine ovarian tumours

Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase receptor CD117 is neo-expressed in many tumours and...

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Autores: Mallon, Hannah E., Ramírez, Gustavo A., Dolenšek, Tamara, Erles, Kerstin, Martí-Garcia, Bernat, Priestnall, Simon L., Suárez-Bonnet, Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/466082
Acceso en línea:https://doi.org/10.1016/j.jcpa.2024.05.001
https://hdl.handle.net/10459.1/466082
Access Level:acceso abierto
Palabra clave:Canine
CD117
Ovarian
Tumour
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spelling CD117 expression in canine ovarian tumoursMallon, Hannah E.Ramírez, Gustavo A.Dolenšek, TamaraErles, KerstinMartí-Garcia, BernatPriestnall, Simon L.Suárez-Bonnet, AlejandroCanineCD117OvarianTumourCanine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase receptor CD117 is neo-expressed in many tumours and represents a potential diagnostic and prognostic biomarker and therapeutic target. This study aimed to establish if CD117 is neoexpressed in canine ovarian tumours. Immunohistochemistry was employed to assess expression of CD117 in 29 canine ovarian tumour samples. CD117 labelling was assessed with a semiquantitative immunoreactivity score, and the location of labelling was recorded as membranous, focal cytoplasmic or diffuse cytoplasmic. Histological morphology was assessed and used to assign subgroups based on growth pattern. Cytokeratin 7 labelling was used to indicate the tumour type as epithelial or sex-cord stromal in origin. Mitotic index, percentage of necrosis and vascular invasion were also assessed and evaluated for association with CD117 expression. Overall, 81% of ovarian tumours neoexpressed CD117 and normal ovarian tissue did not express CD117. Positive immunolabelling was seen in a subset of cells in both ovarian carcinomas (n = 20) and ovarian granulosa cell tumours (n = 3). There was no association between CD117 expression and patient age, histological subtype, mitotic index, percentage of necrosis or vascular invasion. This is the largest study to identify the expression of CD117 in canine ovarian tumours, but further research is needed to elucidate its prognostic and therapeutic value.Elsevier2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1016/j.jcpa.2024.05.001https://hdl.handle.net/10459.1/466082reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.1016/j.jcpa.2024.05.001Journal of Comparative Pathology, 2024, vol. 212, p.1-5cc- by (c) Mallon et al., 2024Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4660822026-06-24T12:42:17Z
dc.title.none.fl_str_mv CD117 expression in canine ovarian tumours
title CD117 expression in canine ovarian tumours
spellingShingle CD117 expression in canine ovarian tumours
Mallon, Hannah E.
Canine
CD117
Ovarian
Tumour
title_short CD117 expression in canine ovarian tumours
title_full CD117 expression in canine ovarian tumours
title_fullStr CD117 expression in canine ovarian tumours
title_full_unstemmed CD117 expression in canine ovarian tumours
title_sort CD117 expression in canine ovarian tumours
dc.creator.none.fl_str_mv Mallon, Hannah E.
Ramírez, Gustavo A.
Dolenšek, Tamara
Erles, Kerstin
Martí-Garcia, Bernat
Priestnall, Simon L.
Suárez-Bonnet, Alejandro
author Mallon, Hannah E.
author_facet Mallon, Hannah E.
Ramírez, Gustavo A.
Dolenšek, Tamara
Erles, Kerstin
Martí-Garcia, Bernat
Priestnall, Simon L.
Suárez-Bonnet, Alejandro
author_role author
author2 Ramírez, Gustavo A.
Dolenšek, Tamara
Erles, Kerstin
Martí-Garcia, Bernat
Priestnall, Simon L.
Suárez-Bonnet, Alejandro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Canine
CD117
Ovarian
Tumour
topic Canine
CD117
Ovarian
Tumour
description Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase receptor CD117 is neo-expressed in many tumours and represents a potential diagnostic and prognostic biomarker and therapeutic target. This study aimed to establish if CD117 is neoexpressed in canine ovarian tumours. Immunohistochemistry was employed to assess expression of CD117 in 29 canine ovarian tumour samples. CD117 labelling was assessed with a semiquantitative immunoreactivity score, and the location of labelling was recorded as membranous, focal cytoplasmic or diffuse cytoplasmic. Histological morphology was assessed and used to assign subgroups based on growth pattern. Cytokeratin 7 labelling was used to indicate the tumour type as epithelial or sex-cord stromal in origin. Mitotic index, percentage of necrosis and vascular invasion were also assessed and evaluated for association with CD117 expression. Overall, 81% of ovarian tumours neoexpressed CD117 and normal ovarian tissue did not express CD117. Positive immunolabelling was seen in a subset of cells in both ovarian carcinomas (n = 20) and ovarian granulosa cell tumours (n = 3). There was no association between CD117 expression and patient age, histological subtype, mitotic index, percentage of necrosis or vascular invasion. This is the largest study to identify the expression of CD117 in canine ovarian tumours, but further research is needed to elucidate its prognostic and therapeutic value.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.jcpa.2024.05.001
https://hdl.handle.net/10459.1/466082
url https://doi.org/10.1016/j.jcpa.2024.05.001
https://hdl.handle.net/10459.1/466082
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1016/j.jcpa.2024.05.001
Journal of Comparative Pathology, 2024, vol. 212, p.1-5
dc.rights.none.fl_str_mv cc- by (c) Mallon et al., 2024
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc- by (c) Mallon et al., 2024
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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