Purinergic receptors in ocular inflammation
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly 'tuned,' can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ....
| Autores: | , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/60525 |
| Acesso em linha: | https://hdl.handle.net/2445/60525 |
| Access Level: | acceso abierto |
| Palavra-chave: | Inflamació Adenosina Nucleòtids Oftalmologia Inflammation Adenosine Nucleotides Ophthalmology |
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Purinergic receptors in ocular inflammationGuzman-Aranguez, A.Gasull Casanova, XavierDiebold, Y.Pintor, Jesús J.InflamacióAdenosinaNucleòtidsOftalmologiaInflammationAdenosineNucleotidesOphthalmologyInflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly 'tuned,' can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P(1),P(4)-diadenosine tetraphosphate (Ap4A), and P(1),P(5)-diadenosine pentaphosphate (Ap5A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A3 receptor, selective agonists like N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation.Hindawi Publishing Corporation2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/60525Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1155/2014/320906Mediators of Inflammation, 2014, vol. 2014, p. 1-11http://dx.doi.org/10.1155/2014/320906cc-by (c) Guzman-Aranguez, A. et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/605252026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Purinergic receptors in ocular inflammation |
| title |
Purinergic receptors in ocular inflammation |
| spellingShingle |
Purinergic receptors in ocular inflammation Guzman-Aranguez, A. Inflamació Adenosina Nucleòtids Oftalmologia Inflammation Adenosine Nucleotides Ophthalmology |
| title_short |
Purinergic receptors in ocular inflammation |
| title_full |
Purinergic receptors in ocular inflammation |
| title_fullStr |
Purinergic receptors in ocular inflammation |
| title_full_unstemmed |
Purinergic receptors in ocular inflammation |
| title_sort |
Purinergic receptors in ocular inflammation |
| dc.creator.none.fl_str_mv |
Guzman-Aranguez, A. Gasull Casanova, Xavier Diebold, Y. Pintor, Jesús J. |
| author |
Guzman-Aranguez, A. |
| author_facet |
Guzman-Aranguez, A. Gasull Casanova, Xavier Diebold, Y. Pintor, Jesús J. |
| author_role |
author |
| author2 |
Gasull Casanova, Xavier Diebold, Y. Pintor, Jesús J. |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Inflamació Adenosina Nucleòtids Oftalmologia Inflammation Adenosine Nucleotides Ophthalmology |
| topic |
Inflamació Adenosina Nucleòtids Oftalmologia Inflammation Adenosine Nucleotides Ophthalmology |
| description |
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly 'tuned,' can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P(1),P(4)-diadenosine tetraphosphate (Ap4A), and P(1),P(5)-diadenosine pentaphosphate (Ap5A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A3 receptor, selective agonists like N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation. |
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2014 |
| dc.date.none.fl_str_mv |
2014 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/60525 |
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https://hdl.handle.net/2445/60525 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Reproducció del document publicat a: http://dx.doi.org/10.1155/2014/320906 Mediators of Inflammation, 2014, vol. 2014, p. 1-11 http://dx.doi.org/10.1155/2014/320906 |
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cc-by (c) Guzman-Aranguez, A. et al., 2014 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
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cc-by (c) Guzman-Aranguez, A. et al., 2014 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
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application/pdf |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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Articles publicats en revistes (Ciències Fisiològiques) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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