Genome-Wide Studies in Ischaemic Stroke

Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies m...

Full description

Bibliographic Details
Authors: Gallego-Fabrega, Cristina|||0000-0003-3229-5512, Muiño, Elena|||0000-0001-5839-7328, Cárcel-Márquez, Jara|||0000-0002-6949-0699, Llucià-Carol, Laia|||0000-0002-7732-0665, Lledós, Miquel|||0000-0001-8832-789X, Martín-Campos, Jesús María|||0000-0003-0414-037X, Cullell, Natalia|||0000-0001-5118-1014, Fernández Cadenas, Israel|||0000-0003-4821-2363
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:280886
Online Access:https://ddd.uab.cat/record/280886
https://dx.doi.org/urn:doi:10.3390/ijms23126840
Access Level:Open access
Keyword:Stroke
GWAS
Epigenetics
Microbiome
id ES_bf5eb57c477a16fdc69cbc9178d86aea
oai_identifier_str oai:ddd.uab.cat:280886
network_acronym_str ES
network_name_str España
repository_id_str
spelling Genome-Wide Studies in Ischaemic StrokeAre Genetics Only Useful for Finding Genes?Gallego-Fabrega, Cristina|||0000-0003-3229-5512Muiño, Elena|||0000-0001-5839-7328Cárcel-Márquez, Jara|||0000-0002-6949-0699Llucià-Carol, Laia|||0000-0002-7732-0665Lledós, Miquel|||0000-0001-8832-789XMartín-Campos, Jesús María|||0000-0003-0414-037XCullell, Natalia|||0000-0001-5118-1014Fernández Cadenas, Israel|||0000-0003-4821-2363StrokeGWASEpigeneticsMicrobiomeIschaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/280886https://dx.doi.org/urn:doi:10.3390/ijms23126840reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01338Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 D21/0006/0006Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM18/00198Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CD20/00043Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI19/00309Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CP12/03298Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 FI_DGR2020Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2020FI_B100157open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2808862026-06-06T12:50:31Z
dc.title.none.fl_str_mv Genome-Wide Studies in Ischaemic Stroke
Are Genetics Only Useful for Finding Genes?
title Genome-Wide Studies in Ischaemic Stroke
spellingShingle Genome-Wide Studies in Ischaemic Stroke
Gallego-Fabrega, Cristina|||0000-0003-3229-5512
Stroke
GWAS
Epigenetics
Microbiome
title_short Genome-Wide Studies in Ischaemic Stroke
title_full Genome-Wide Studies in Ischaemic Stroke
title_fullStr Genome-Wide Studies in Ischaemic Stroke
title_full_unstemmed Genome-Wide Studies in Ischaemic Stroke
title_sort Genome-Wide Studies in Ischaemic Stroke
dc.creator.none.fl_str_mv Gallego-Fabrega, Cristina|||0000-0003-3229-5512
Muiño, Elena|||0000-0001-5839-7328
Cárcel-Márquez, Jara|||0000-0002-6949-0699
Llucià-Carol, Laia|||0000-0002-7732-0665
Lledós, Miquel|||0000-0001-8832-789X
Martín-Campos, Jesús María|||0000-0003-0414-037X
Cullell, Natalia|||0000-0001-5118-1014
Fernández Cadenas, Israel|||0000-0003-4821-2363
author Gallego-Fabrega, Cristina|||0000-0003-3229-5512
author_facet Gallego-Fabrega, Cristina|||0000-0003-3229-5512
Muiño, Elena|||0000-0001-5839-7328
Cárcel-Márquez, Jara|||0000-0002-6949-0699
Llucià-Carol, Laia|||0000-0002-7732-0665
Lledós, Miquel|||0000-0001-8832-789X
Martín-Campos, Jesús María|||0000-0003-0414-037X
Cullell, Natalia|||0000-0001-5118-1014
Fernández Cadenas, Israel|||0000-0003-4821-2363
author_role author
author2 Muiño, Elena|||0000-0001-5839-7328
Cárcel-Márquez, Jara|||0000-0002-6949-0699
Llucià-Carol, Laia|||0000-0002-7732-0665
Lledós, Miquel|||0000-0001-8832-789X
Martín-Campos, Jesús María|||0000-0003-0414-037X
Cullell, Natalia|||0000-0001-5118-1014
Fernández Cadenas, Israel|||0000-0003-4821-2363
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Stroke
GWAS
Epigenetics
Microbiome
topic Stroke
GWAS
Epigenetics
Microbiome
description Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/280886
https://dx.doi.org/urn:doi:10.3390/ijms23126840
url https://ddd.uab.cat/record/280886
https://dx.doi.org/urn:doi:10.3390/ijms23126840
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01338
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 D21/0006/0006
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM18/00198
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CD20/00043
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI19/00309
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CP12/03298
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 FI_DGR2020
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2020FI_B100157
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418363649785856
score 15,811543

Similar Items