Antitumoral effect of ocoxin in hepatocellular carcinoma

[EN]Hepatocellular carcinoma (HCC) is becoming one of the most prevalent types of cancer worldwide. The most efficient types of treatment at present include surgical resection and liver transplantation, but these treatments may only be used in a small percentage of patients. In order to identify nov...

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Autores: Díaz Rodríguez, María Elena, El-Mallah, Al-Mahy, Sanz, Eduardo, Pandiella Alonso, Atanasio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:dnet:gredos______::710422c2d2eb9a48ab00f5891d6678dd
Acceso en línea:http://hdl.handle.net/10366/170913
Access Level:acceso embargado
Palabra clave:Antioxidants
Cell cycle
Hepatocellular carcinoma
Carcinoma, Hepatocellular
Cell Cycle
2302 Bioquímica
3207.13 Oncología
ciclo celular
antioxidantes
carcinoma hepatocelular
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oai_identifier_str oai:dnet:gredos______::710422c2d2eb9a48ab00f5891d6678dd
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spelling Antitumoral effect of ocoxin in hepatocellular carcinomaDíaz Rodríguez, María ElenaEl-Mallah, Al-MahySanz, EduardoPandiella Alonso, AtanasioAntioxidantsCell cycleHepatocellular carcinomaAntioxidantsCarcinoma, HepatocellularCell Cycle2302 Bioquímica3207.13 Oncologíaciclo celularantioxidantescarcinoma hepatocelular[EN]Hepatocellular carcinoma (HCC) is becoming one of the most prevalent types of cancer worldwide. The most efficient types of treatment at present include surgical resection and liver transplantation, but these treatments may only be used in a small percentage of patients. In order to identify novel therapeutic strategies for this disease, the present study explored the potential antitumoral effect of Ocoxin® oral solution (OOS) in HCC. OOS inhibited the proliferation of HCC cell lines in a time- and dose-dependent manner, being more efficient when used in combination with sorafenib, a standard of care treatment for patients diagnosed with advanced-stage disease. Mechanistic studies indicated that the effect of OOS was due to the induction of cell cycle arrest rather than the stimulation of apoptotic cell death. The cell cycle was slowed down in all phases in the HCC cell lines treated with OOS. Finally, when tested in animal models of HCC, OOS reduced tumor progression through the induction of necrosis in xenograft tumor models. Considering the poor prognosis and high resistance to antitumor treatments of HCC, the antiproliferative action of OOS, particularly in combination with sorafenib, provides the opportunity to investigate the effect of combined therapy in a clinical setting.Spandidos Publicationsinfo202620262017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/170913reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésBFU2012-39151AECC12/GC02Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:dnet:gredos______::710422c2d2eb9a48ab00f5891d6678dd2026-06-07T06:28:51Z
dc.title.none.fl_str_mv Antitumoral effect of ocoxin in hepatocellular carcinoma
title Antitumoral effect of ocoxin in hepatocellular carcinoma
spellingShingle Antitumoral effect of ocoxin in hepatocellular carcinoma
Díaz Rodríguez, María Elena
Antioxidants
Cell cycle
Hepatocellular carcinoma
Antioxidants
Carcinoma, Hepatocellular
Cell Cycle
2302 Bioquímica
3207.13 Oncología
ciclo celular
antioxidantes
carcinoma hepatocelular
title_short Antitumoral effect of ocoxin in hepatocellular carcinoma
title_full Antitumoral effect of ocoxin in hepatocellular carcinoma
title_fullStr Antitumoral effect of ocoxin in hepatocellular carcinoma
title_full_unstemmed Antitumoral effect of ocoxin in hepatocellular carcinoma
title_sort Antitumoral effect of ocoxin in hepatocellular carcinoma
dc.creator.none.fl_str_mv Díaz Rodríguez, María Elena
El-Mallah, Al-Mahy
Sanz, Eduardo
Pandiella Alonso, Atanasio
author Díaz Rodríguez, María Elena
author_facet Díaz Rodríguez, María Elena
El-Mallah, Al-Mahy
Sanz, Eduardo
Pandiella Alonso, Atanasio
author_role author
author2 El-Mallah, Al-Mahy
Sanz, Eduardo
Pandiella Alonso, Atanasio
author2_role author
author
author
dc.subject.none.fl_str_mv Antioxidants
Cell cycle
Hepatocellular carcinoma
Antioxidants
Carcinoma, Hepatocellular
Cell Cycle
2302 Bioquímica
3207.13 Oncología
ciclo celular
antioxidantes
carcinoma hepatocelular
topic Antioxidants
Cell cycle
Hepatocellular carcinoma
Antioxidants
Carcinoma, Hepatocellular
Cell Cycle
2302 Bioquímica
3207.13 Oncología
ciclo celular
antioxidantes
carcinoma hepatocelular
description [EN]Hepatocellular carcinoma (HCC) is becoming one of the most prevalent types of cancer worldwide. The most efficient types of treatment at present include surgical resection and liver transplantation, but these treatments may only be used in a small percentage of patients. In order to identify novel therapeutic strategies for this disease, the present study explored the potential antitumoral effect of Ocoxin® oral solution (OOS) in HCC. OOS inhibited the proliferation of HCC cell lines in a time- and dose-dependent manner, being more efficient when used in combination with sorafenib, a standard of care treatment for patients diagnosed with advanced-stage disease. Mechanistic studies indicated that the effect of OOS was due to the induction of cell cycle arrest rather than the stimulation of apoptotic cell death. The cell cycle was slowed down in all phases in the HCC cell lines treated with OOS. Finally, when tested in animal models of HCC, OOS reduced tumor progression through the induction of necrosis in xenograft tumor models. Considering the poor prognosis and high resistance to antitumor treatments of HCC, the antiproliferative action of OOS, particularly in combination with sorafenib, provides the opportunity to investigate the effect of combined therapy in a clinical setting.
publishDate 2017
dc.date.none.fl_str_mv 2017
2026
2026
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/170913
url http://hdl.handle.net/10366/170913
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BFU2012-39151
AECC12/GC02
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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