Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry

Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the...

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Autores: González Muñoza, Carlos, Giordano, Antonio, Ricart, Elena (Ricart Gómez), Nos, Pilar, Iglesias, Eva, Gisbert, Javier P., García López, Santiago, Mesonero, Francisco, Pascual, Isabel, Tardillo, Carlos, Rivero, Montserrat, Riestra, Sabino, Mañosa, Míriam, Zabana Abdo, Yamile, Gomollón García, Fernando, Calvet Calvo, Xavier, García Sepulcre, Mariana Fe, Gutiérrez, Ana, Pérez Calle, José Lázaro, Sierra Ausín, Mónica, Bermejo, Fernando, Arias García, Lara, Barreiro de Acosta, Manuel, Barrio, Jesús, Lorente, Rufo, Guardiola, Jordi, Varela, Pilar, Ponferrada Díaz, Ángel, Marín Jiménez, Ignacio, Martínez Pascual, Cristina, García Planella, Esther, Domènech, Eugeni, ENEIDAregistry of GETECCU
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/222232
Acesso em linha:https://hdl.handle.net/2445/222232
Access Level:acceso abierto
Palavra-chave:Malalties inflamatòries intestinals
Terapèutica
Inflammatory bowel diseases
Therapeutics
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spelling Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA RegistryGonzález Muñoza, CarlosGiordano, AntonioRicart, Elena (Ricart Gómez)Nos, PilarIglesias, EvaGisbert, Javier P.García López, SantiagoMesonero, FranciscoPascual, IsabelTardillo, CarlosRivero, MontserratRiestra, SabinoMañosa, MíriamZabana Abdo, YamileGomollón García, FernandoCalvet Calvo, XavierGarcía Sepulcre, Mariana FeGutiérrez, AnaPérez Calle, José LázaroSierra Ausín, MónicaBermejo, FernandoArias García, LaraBarreiro de Acosta, ManuelBarrio, JesúsLorente, RufoGuardiola, JordiVarela, PilarPonferrada Díaz, ÁngelMarín Jiménez, IgnacioMartínez Pascual, CristinaGarcía Planella, EstherDomènech, EugeniENEIDAregistry of GETECCUMalalties inflamatòries intestinalsTerapèuticaInflammatory bowel diseasesTherapeuticsBackground: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case-control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn's disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD.MDPI2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/222232Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm14103352Journal of Clinical Medicine, 2025, vol. 14, num. 10, 3352https://doi.org/10.3390/jcm14103352cc-by (c) González Muñoza, Carlos et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2222322026-05-29T05:05:01Z
dc.title.none.fl_str_mv Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
spellingShingle Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
González Muñoza, Carlos
Malalties inflamatòries intestinals
Terapèutica
Inflammatory bowel diseases
Therapeutics
title_short Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_full Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_fullStr Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_full_unstemmed Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
title_sort Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
dc.creator.none.fl_str_mv González Muñoza, Carlos
Giordano, Antonio
Ricart, Elena (Ricart Gómez)
Nos, Pilar
Iglesias, Eva
Gisbert, Javier P.
García López, Santiago
Mesonero, Francisco
Pascual, Isabel
Tardillo, Carlos
Rivero, Montserrat
Riestra, Sabino
Mañosa, Míriam
Zabana Abdo, Yamile
Gomollón García, Fernando
Calvet Calvo, Xavier
García Sepulcre, Mariana Fe
Gutiérrez, Ana
Pérez Calle, José Lázaro
Sierra Ausín, Mónica
Bermejo, Fernando
Arias García, Lara
Barreiro de Acosta, Manuel
Barrio, Jesús
Lorente, Rufo
Guardiola, Jordi
Varela, Pilar
Ponferrada Díaz, Ángel
Marín Jiménez, Ignacio
Martínez Pascual, Cristina
García Planella, Esther
Domènech, Eugeni
ENEIDAregistry of GETECCU
author González Muñoza, Carlos
author_facet González Muñoza, Carlos
Giordano, Antonio
Ricart, Elena (Ricart Gómez)
Nos, Pilar
Iglesias, Eva
Gisbert, Javier P.
García López, Santiago
Mesonero, Francisco
Pascual, Isabel
Tardillo, Carlos
Rivero, Montserrat
Riestra, Sabino
Mañosa, Míriam
Zabana Abdo, Yamile
Gomollón García, Fernando
Calvet Calvo, Xavier
García Sepulcre, Mariana Fe
Gutiérrez, Ana
Pérez Calle, José Lázaro
Sierra Ausín, Mónica
Bermejo, Fernando
Arias García, Lara
Barreiro de Acosta, Manuel
Barrio, Jesús
Lorente, Rufo
Guardiola, Jordi
Varela, Pilar
Ponferrada Díaz, Ángel
Marín Jiménez, Ignacio
Martínez Pascual, Cristina
García Planella, Esther
Domènech, Eugeni
ENEIDAregistry of GETECCU
author_role author
author2 Giordano, Antonio
Ricart, Elena (Ricart Gómez)
Nos, Pilar
Iglesias, Eva
Gisbert, Javier P.
García López, Santiago
Mesonero, Francisco
Pascual, Isabel
Tardillo, Carlos
Rivero, Montserrat
Riestra, Sabino
Mañosa, Míriam
Zabana Abdo, Yamile
Gomollón García, Fernando
Calvet Calvo, Xavier
García Sepulcre, Mariana Fe
Gutiérrez, Ana
Pérez Calle, José Lázaro
Sierra Ausín, Mónica
Bermejo, Fernando
Arias García, Lara
Barreiro de Acosta, Manuel
Barrio, Jesús
Lorente, Rufo
Guardiola, Jordi
Varela, Pilar
Ponferrada Díaz, Ángel
Marín Jiménez, Ignacio
Martínez Pascual, Cristina
García Planella, Esther
Domènech, Eugeni
ENEIDAregistry of GETECCU
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties inflamatòries intestinals
Terapèutica
Inflammatory bowel diseases
Therapeutics
topic Malalties inflamatòries intestinals
Terapèutica
Inflammatory bowel diseases
Therapeutics
description Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case-control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn's disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222232
url https://hdl.handle.net/2445/222232
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm14103352
Journal of Clinical Medicine, 2025, vol. 14, num. 10, 3352
https://doi.org/10.3390/jcm14103352
dc.rights.none.fl_str_mv cc-by (c) González Muñoza, Carlos et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) González Muñoza, Carlos et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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