Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response

Background After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods...

Descripción completa

Detalles Bibliográficos
Autores: Martín-Carmona, J, Corma-Gómez, A, Moyano, JM, Téllez, F, Arenga-Barrios, D, Serrano-Fuentes, M, Vázquez, ACM, Corona-Mata, D, Lorite, MNN, Vera-Méndez, FJ, Barroso, I, Palacios, R, de los Santos, I, Belinchón, O, Galera, C, Imaz, A, Merino, D, Reus-Bañuls, SJ, Galindo, MJ, López-Zuñiga, MA, Pineda, JA, Macías, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20652
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/20652
Access Level:acceso abierto
Palabra clave:Liver stiffness
HIV
Hepatitis C
Sustained viral response
Transient elastography
id ES_bf1ca4be3fad642a347de2edbb499785
oai_identifier_str oai:incliva.fundanetsuite.com:p20652
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological responseMartín-Carmona, JCorma-Gómez, AMoyano, JMTéllez, FArenga-Barrios, DSerrano-Fuentes, MVázquez, ACMCorona-Mata, DLorite, MNNVera-Méndez, FJBarroso, IPalacios, Rde los Santos, IBelinchón, OGalera, CImaz, AMerino, DReus-Bañuls, SJGalindo, MJLópez-Zuñiga, MAPineda, JAMacías, JLiver stiffnessHIVHepatitis CSustained viral responseTransient elastographyBackground After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods Prospective study conducted in the GEHEP-011 multicenter cohort (initiated in October 2011-November 2023, ID NCT04460157), including patients with chronic HCV infection, with or without HIV co-infection, fulfilling: 1) SVR with direct-acting antivirals; 2) pre-treatment LS >= 9.5 kPa; 3) available measurement of LS at SVR. Pre-treatment, SVR and annual post-treatment LS were assessed. The primary outcome was time to LS normalization achievement (<= 7.2 kPa) in two consecutive examinations. Findings 1138 patients were included, 678 (60%) of whom were living with HIV (PLWH). The median time between the first to the last measure was 35 (17-69) months. In total, 390 [34% (95% confidence interval, 31%-37%)] patients achieved LS normalization, 169 [37% (CI 95%, 34%-43%)] individuals with HCV mono-infection vs. 221 [32% (CI 95%, 29%-36%)] PLWH achieved LS normalization (p = 0.003). The propensity score (PS) for HIV infection was calculated. In a multivariate model for competing risks (death was the competing event) adjusted for HIV, PS and diabetes, HIV infection was associated with a lower probability of achieving normalization [sHR = 0.82 (95% CI, 0.67-1.00), p = 0.045]. Matching by closer PS was performed. In the resultant subset, the probability of achieving LS normalization was again lower in PLWH [sHR = 0.76 (0.56-0.97), p < 0.001]. Interpretation After SVR, the probability of reaching LS normalization is significantly lower in PLWH. This could have implications on the development of long-term clinical events. Copyright (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).ELSEVIER2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20652EClinicalMedicineISSN: 25895370reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p206522026-06-07T16:35:31Z
dc.title.none.fl_str_mv Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
spellingShingle Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
Martín-Carmona, J
Liver stiffness
HIV
Hepatitis C
Sustained viral response
Transient elastography
title_short Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_full Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_fullStr Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_full_unstemmed Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
title_sort Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
dc.creator.none.fl_str_mv Martín-Carmona, J
Corma-Gómez, A
Moyano, JM
Téllez, F
Arenga-Barrios, D
Serrano-Fuentes, M
Vázquez, ACM
Corona-Mata, D
Lorite, MNN
Vera-Méndez, FJ
Barroso, I
Palacios, R
de los Santos, I
Belinchón, O
Galera, C
Imaz, A
Merino, D
Reus-Bañuls, SJ
Galindo, MJ
López-Zuñiga, MA
Pineda, JA
Macías, J
author Martín-Carmona, J
author_facet Martín-Carmona, J
Corma-Gómez, A
Moyano, JM
Téllez, F
Arenga-Barrios, D
Serrano-Fuentes, M
Vázquez, ACM
Corona-Mata, D
Lorite, MNN
Vera-Méndez, FJ
Barroso, I
Palacios, R
de los Santos, I
Belinchón, O
Galera, C
Imaz, A
Merino, D
Reus-Bañuls, SJ
Galindo, MJ
López-Zuñiga, MA
Pineda, JA
Macías, J
author_role author
author2 Corma-Gómez, A
Moyano, JM
Téllez, F
Arenga-Barrios, D
Serrano-Fuentes, M
Vázquez, ACM
Corona-Mata, D
Lorite, MNN
Vera-Méndez, FJ
Barroso, I
Palacios, R
de los Santos, I
Belinchón, O
Galera, C
Imaz, A
Merino, D
Reus-Bañuls, SJ
Galindo, MJ
López-Zuñiga, MA
Pineda, JA
Macías, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Liver stiffness
HIV
Hepatitis C
Sustained viral response
Transient elastography
topic Liver stiffness
HIV
Hepatitis C
Sustained viral response
Transient elastography
description Background After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods Prospective study conducted in the GEHEP-011 multicenter cohort (initiated in October 2011-November 2023, ID NCT04460157), including patients with chronic HCV infection, with or without HIV co-infection, fulfilling: 1) SVR with direct-acting antivirals; 2) pre-treatment LS >= 9.5 kPa; 3) available measurement of LS at SVR. Pre-treatment, SVR and annual post-treatment LS were assessed. The primary outcome was time to LS normalization achievement (<= 7.2 kPa) in two consecutive examinations. Findings 1138 patients were included, 678 (60%) of whom were living with HIV (PLWH). The median time between the first to the last measure was 35 (17-69) months. In total, 390 [34% (95% confidence interval, 31%-37%)] patients achieved LS normalization, 169 [37% (CI 95%, 34%-43%)] individuals with HCV mono-infection vs. 221 [32% (CI 95%, 29%-36%)] PLWH achieved LS normalization (p = 0.003). The propensity score (PS) for HIV infection was calculated. In a multivariate model for competing risks (death was the competing event) adjusted for HIV, PS and diabetes, HIV infection was associated with a lower probability of achieving normalization [sHR = 0.82 (95% CI, 0.67-1.00), p = 0.045]. Matching by closer PS was performed. In the resultant subset, the probability of achieving LS normalization was again lower in PLWH [sHR = 0.76 (0.56-0.97), p < 0.001]. Interpretation After SVR, the probability of reaching LS normalization is significantly lower in PLWH. This could have implications on the development of long-term clinical events. Copyright (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/20652
url https://incliva.portalinvestigacion.com/publicaciones/20652
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv EClinicalMedicine
ISSN: 25895370
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418342277709824
score 15,811543

Similares en LA Referencia