Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome

31 pags., 7 figs. -- Part of the Subcellular Biochemistry book series (SCBI,volume 99)

Detalles Bibliográficos
Autores: Alcorlo, Martín, Martínez-Caballero, Siseth, Molina, Rafael, Hermoso, Juan A.
Tipo de recurso: otro
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/288783
Acceso en línea:http://hdl.handle.net/10261/288783
https://api.elsevier.com/content/abstract/scopus_id/85138460772
Access Level:acceso abierto
Palabra clave:3D structure
ABC transporters
Bacterial division
Divisome
FtsE
FtsX
Lytic regulation
Mechano-transmission
PcsB
SPOR
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spelling Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial DivisomeAlcorlo, MartínMartínez-Caballero, SisethMolina, RafaelHermoso, Juan A.3D structureABC transportersBacterial divisionDivisomeFtsEFtsXLytic regulationMechano-transmissionPcsBSPOR31 pags., 7 figs. -- Part of the Subcellular Biochemistry book series (SCBI,volume 99)The essential membrane complex FtsE/FtsX (FtsEX), belonging to the ABC transporter superfamily and widespread among bacteria, plays a relevant function in some crucial cell wall remodeling processes such as cell division, elongation, or sporulation. FtsEX plays a double role by recruiting proteins to the divisome apparatus and by regulating lytic activity of the cell wall hydrolases required for daughter cell separation. Interestingly, FtsEX does not act as a transporter but uses the ATPase activity of FtsE to mechanically transmit a signal from the cytosol, through the membrane, to the periplasm that activates the attached hydrolases. While the complete molecular details of such mechanism are not yet known, evidence has been recently reported that clarify essential aspects of this complex system. In this chapter we will present recent structural advances on this topic. The three-dimensional structure of FtsE, FtsX, and some of the lytic enzymes or their cognate regulators revealed an unexpected scenario in which a delicate set of intermolecular interactions, conserved among different bacterial genera, could be at the core of this regulatory mechanism providing exquisite control in both space and time of this central process to assist bacterial survival.This study was funded by the Spanish Ministry of Science and Innovation, which is part of Agencia Estatal de Investigación (AEI), through the project PID2020-115331GB-100.Peer reviewedSpringer NatureAgencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Postprintinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/288783https://api.elsevier.com/content/abstract/scopus_id/85138460772reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115331GB-I00Sub-cellular biochemistryhttps://doi.org/10.1007/978-3-031-00793-4_9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2887832026-05-22T06:33:51Z
dc.title.none.fl_str_mv Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
title Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
spellingShingle Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
Alcorlo, Martín
3D structure
ABC transporters
Bacterial division
Divisome
FtsE
FtsX
Lytic regulation
Mechano-transmission
PcsB
SPOR
title_short Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
title_full Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
title_fullStr Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
title_full_unstemmed Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
title_sort Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
dc.creator.none.fl_str_mv Alcorlo, Martín
Martínez-Caballero, Siseth
Molina, Rafael
Hermoso, Juan A.
author Alcorlo, Martín
author_facet Alcorlo, Martín
Martínez-Caballero, Siseth
Molina, Rafael
Hermoso, Juan A.
author_role author
author2 Martínez-Caballero, Siseth
Molina, Rafael
Hermoso, Juan A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 3D structure
ABC transporters
Bacterial division
Divisome
FtsE
FtsX
Lytic regulation
Mechano-transmission
PcsB
SPOR
topic 3D structure
ABC transporters
Bacterial division
Divisome
FtsE
FtsX
Lytic regulation
Mechano-transmission
PcsB
SPOR
description 31 pags., 7 figs. -- Part of the Subcellular Biochemistry book series (SCBI,volume 99)
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Postprint
info:eu-repo/semantics/acceptedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/288783
https://api.elsevier.com/content/abstract/scopus_id/85138460772
url http://hdl.handle.net/10261/288783
https://api.elsevier.com/content/abstract/scopus_id/85138460772
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115331GB-I00
Sub-cellular biochemistry
https://doi.org/10.1007/978-3-031-00793-4_9
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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