Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations

The decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures a...

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Autores: Delgado González, José Carlos, Mansilla Legorburo, Francisco, Florensa Vila, José, Insausti Serrano, Ana María, Viñuela, Antonio, Tuñón Álvarez, Teresa, Cruz, Marcos, Mohedano Moriano, Alicia, Insausti, Ricardo, Artacho Pérula, Emilio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Recursos:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/30550
Acesso em linha:https://hdl.handle.net/2454/30550
Access Level:acceso abierto
Palavra-chave:Ex-vivo MRI
Medial temporal lobe structures
Histological preparations
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spelling Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparationsDelgado González, José CarlosMansilla Legorburo, FranciscoFlorensa Vila, JoséInsausti Serrano, Ana MaríaViñuela, AntonioTuñón Álvarez, TeresaCruz, MarcosMohedano Moriano, AliciaInsausti, RicardoArtacho Pérula, EmilioEx-vivo MRIMedial temporal lobe structuresHistological preparationsThe decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures and their quantitative estimate in microscopic examination. Twelve control cases had ex-vivo MRI, and thereafter, the temporal lobe of both hemispheres was sectioned from the pole as far as the level of the splenium of the corpus callosum. Nissl stain was used to establish anatomical boundaries between structures in the medial temporal lobe. The study included morphometrical and stereological estimates of the amygdaloid complex, hippocampus, and temporal horn of the lateral ventricle, as well as different regions of grey and white matter in the temporal lobe. Data showed a close association between morphometric MRI images values and those based on the histological determination of boundaries. Only values in perimeter and circularity of the piamater were different. This correspondence is also revealed by the stereological study, although irregular compartments resulted in a lesser agreement. Neither age (< 65 yr and > 65yr) nor hemisphere had any effect. Our results indicate that ex-vivo MRI is highly associated with quantitative information gathered by histological examination, and these data could be used as structural MRI biomarker in neurodegenerative diseases.This study was funded by the Spanish Ministry of Science and Innovation I+D+i Project BFU-2009-14705 (EAP and RI), the Education, Culture and Sports of Castilla-La Mancha Autonomic Government Project PPII-2014-013-A (EAP and RI), and from the Health Research Foundation of Castilla- La Mancha (FISCAM) Project PI-2007-59.PLOSCiencias de la SaludOsasun Zientziak2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/30550reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© 2015 Delgado-González et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/305502026-06-17T12:41:47Z
dc.title.none.fl_str_mv Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
title Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
spellingShingle Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
Delgado González, José Carlos
Ex-vivo MRI
Medial temporal lobe structures
Histological preparations
title_short Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
title_full Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
title_fullStr Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
title_full_unstemmed Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
title_sort Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
dc.creator.none.fl_str_mv Delgado González, José Carlos
Mansilla Legorburo, Francisco
Florensa Vila, José
Insausti Serrano, Ana María
Viñuela, Antonio
Tuñón Álvarez, Teresa
Cruz, Marcos
Mohedano Moriano, Alicia
Insausti, Ricardo
Artacho Pérula, Emilio
author Delgado González, José Carlos
author_facet Delgado González, José Carlos
Mansilla Legorburo, Francisco
Florensa Vila, José
Insausti Serrano, Ana María
Viñuela, Antonio
Tuñón Álvarez, Teresa
Cruz, Marcos
Mohedano Moriano, Alicia
Insausti, Ricardo
Artacho Pérula, Emilio
author_role author
author2 Mansilla Legorburo, Francisco
Florensa Vila, José
Insausti Serrano, Ana María
Viñuela, Antonio
Tuñón Álvarez, Teresa
Cruz, Marcos
Mohedano Moriano, Alicia
Insausti, Ricardo
Artacho Pérula, Emilio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Ex-vivo MRI
Medial temporal lobe structures
Histological preparations
topic Ex-vivo MRI
Medial temporal lobe structures
Histological preparations
description The decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures and their quantitative estimate in microscopic examination. Twelve control cases had ex-vivo MRI, and thereafter, the temporal lobe of both hemispheres was sectioned from the pole as far as the level of the splenium of the corpus callosum. Nissl stain was used to establish anatomical boundaries between structures in the medial temporal lobe. The study included morphometrical and stereological estimates of the amygdaloid complex, hippocampus, and temporal horn of the lateral ventricle, as well as different regions of grey and white matter in the temporal lobe. Data showed a close association between morphometric MRI images values and those based on the histological determination of boundaries. Only values in perimeter and circularity of the piamater were different. This correspondence is also revealed by the stereological study, although irregular compartments resulted in a lesser agreement. Neither age (< 65 yr and > 65yr) nor hemisphere had any effect. Our results indicate that ex-vivo MRI is highly associated with quantitative information gathered by histological examination, and these data could be used as structural MRI biomarker in neurodegenerative diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/30550
url https://hdl.handle.net/2454/30550
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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repository.mail.fl_str_mv
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