The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34

Overarching themes in the terminal differentiation of the enteric nervous system, an autonomously acting unit of animal nervous systems, have so far eluded discovery. We describe here the overall regulatory logic of enteric nervous system differentiation of the nematode Caenorhabditis elegans that r...

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Autores: Vidal, Berta, Gulez, Burcu, Cao, Wen Xi, Leyva-Díaz, Eduardo, Reilly, Molly B, Tekieli, Tessa, Hobert, Oliver
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/38425
Acceso en línea:https://hdl.handle.net/11000/38425
Access Level:acceso abierto
Palabra clave:enteric nervous system
homeobox gene
neuronal fate
neuroscience
transcriptional control
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spelling The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34Vidal, BertaGulez, BurcuCao, Wen XiLeyva-Díaz, EduardoReilly, Molly BTekieli, TessaHobert, Oliverenteric nervous systemhomeobox geneneuronal fateneurosciencetranscriptional controlOverarching themes in the terminal differentiation of the enteric nervous system, an autonomously acting unit of animal nervous systems, have so far eluded discovery. We describe here the overall regulatory logic of enteric nervous system differentiation of the nematode Caenorhabditis elegans that resides within the foregut (pharynx) of the worm. A C. elegans homolog of the Drosophila Sine oculis homeobox gene, ceh-34, is expressed in all 14 classes of interconnected pharyngeal neurons from their birth throughout their life time, but in no other neuron type of the entire animal. Constitutive and temporally controlled ceh-34 removal shows that ceh-34 is required to initiate and maintain the neuron type-specific terminal differentiation program of all pharyngeal neuron classes, including their circuit assembly. Through additional genetic loss of function analysis, we show that within each pharyngeal neuron class, ceh-34 cooperates with different homeodomain transcription factors to individuate distinct pharyngeal neuron classes. Our analysis underscores the critical role of homeobox genes in neuronal identity specification and links them to the control of neuronal circuit assembly of the enteric nervous system. Together with the pharyngeal nervous system simplicity as well as its specification by a Sine oculis homolog, our findings invite speculations about the early evolution of nervous systems.Portman UniversityInstitutos de la UMH::Instituto de Neurociencias202520252022info:eu-repo/semantics/articleapplication/pdf34application/pdfhttps://hdl.handle.net/11000/38425reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.7554/eLife.76003info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/384252026-05-27T13:36:21Z
dc.title.none.fl_str_mv The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
title The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
spellingShingle The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
Vidal, Berta
enteric nervous system
homeobox gene
neuronal fate
neuroscience
transcriptional control
title_short The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
title_full The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
title_fullStr The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
title_full_unstemmed The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
title_sort The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
dc.creator.none.fl_str_mv Vidal, Berta
Gulez, Burcu
Cao, Wen Xi
Leyva-Díaz, Eduardo
Reilly, Molly B
Tekieli, Tessa
Hobert, Oliver
author Vidal, Berta
author_facet Vidal, Berta
Gulez, Burcu
Cao, Wen Xi
Leyva-Díaz, Eduardo
Reilly, Molly B
Tekieli, Tessa
Hobert, Oliver
author_role author
author2 Gulez, Burcu
Cao, Wen Xi
Leyva-Díaz, Eduardo
Reilly, Molly B
Tekieli, Tessa
Hobert, Oliver
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institutos de la UMH::Instituto de Neurociencias
dc.subject.none.fl_str_mv enteric nervous system
homeobox gene
neuronal fate
neuroscience
transcriptional control
topic enteric nervous system
homeobox gene
neuronal fate
neuroscience
transcriptional control
description Overarching themes in the terminal differentiation of the enteric nervous system, an autonomously acting unit of animal nervous systems, have so far eluded discovery. We describe here the overall regulatory logic of enteric nervous system differentiation of the nematode Caenorhabditis elegans that resides within the foregut (pharynx) of the worm. A C. elegans homolog of the Drosophila Sine oculis homeobox gene, ceh-34, is expressed in all 14 classes of interconnected pharyngeal neurons from their birth throughout their life time, but in no other neuron type of the entire animal. Constitutive and temporally controlled ceh-34 removal shows that ceh-34 is required to initiate and maintain the neuron type-specific terminal differentiation program of all pharyngeal neuron classes, including their circuit assembly. Through additional genetic loss of function analysis, we show that within each pharyngeal neuron class, ceh-34 cooperates with different homeodomain transcription factors to individuate distinct pharyngeal neuron classes. Our analysis underscores the critical role of homeobox genes in neuronal identity specification and links them to the control of neuronal circuit assembly of the enteric nervous system. Together with the pharyngeal nervous system simplicity as well as its specification by a Sine oculis homolog, our findings invite speculations about the early evolution of nervous systems.
publishDate 2022
dc.date.none.fl_str_mv 2022
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/38425
url https://hdl.handle.net/11000/38425
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.7554/eLife.76003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
34
application/pdf
dc.publisher.none.fl_str_mv Portman University
publisher.none.fl_str_mv Portman University
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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