Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

We recently observed reduced autophagy in Crohn's disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn...

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Autores: Cosin-Roger J, Canet F, Macias-Ceja DC, Gisbert-Ferrándiz L, Ortiz-Masiá D, Esplugues JV, Alós R, Navarro F, Barrachina MD, Calatayud S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p3972
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/3972
Access Level:acceso abierto
Palabra clave:intestinal fibrosis
autophagy
inflammation
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spelling Autophagy Stimulation as a Potential Strategy Against Intestinal FibrosisCosin-Roger JCanet FMacias-Ceja DCGisbert-Ferrándiz LOrtiz-Masiá DEsplugues JVAlós RNavarro FBarrachina MDCalatayud Sintestinal fibrosisautophagyinflammationWe recently observed reduced autophagy in Crohn's disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn's disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/3972CellsISSN: 20734409reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p39722026-06-11T12:45:17Z
dc.title.none.fl_str_mv Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
spellingShingle Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
Cosin-Roger J
intestinal fibrosis
autophagy
inflammation
title_short Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_full Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_fullStr Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_full_unstemmed Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_sort Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
dc.creator.none.fl_str_mv Cosin-Roger J
Canet F
Macias-Ceja DC
Gisbert-Ferrándiz L
Ortiz-Masiá D
Esplugues JV
Alós R
Navarro F
Barrachina MD
Calatayud S
author Cosin-Roger J
author_facet Cosin-Roger J
Canet F
Macias-Ceja DC
Gisbert-Ferrándiz L
Ortiz-Masiá D
Esplugues JV
Alós R
Navarro F
Barrachina MD
Calatayud S
author_role author
author2 Canet F
Macias-Ceja DC
Gisbert-Ferrándiz L
Ortiz-Masiá D
Esplugues JV
Alós R
Navarro F
Barrachina MD
Calatayud S
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv intestinal fibrosis
autophagy
inflammation
topic intestinal fibrosis
autophagy
inflammation
description We recently observed reduced autophagy in Crohn's disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn's disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/3972
url https://fisabio.portalinvestigacion.com/publicaciones/3972
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Cells
ISSN: 20734409
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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