Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer

Purpose: Current clinical prognostic factors are not accurate enough to identify and monitor those muscle-invasive bladder cancer (MIBC) patients at high risk of progression after radical cystectomy (RC). Here, we determined genetic alterations in the tumor and circulating tumor cell (CTC) enumerati...

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Autores: Carrasco, Raquel, Ingelmo-Torres, Mercedes, Gómez, Ascensión, Roldán, Fiorella L., Segura, Natalia, Ribal, María José, Alcaraz Asensio, Antonio, Izquierdo Reyes, Laura, Mengual Brichs, Lourdes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214269
Acceso en línea:https://hdl.handle.net/2445/214269
Access Level:acceso abierto
Palabra clave:Pronòstic mèdic
Urologia
Càncer de bufeta
Marcadors tumorals
Prognosis
Urology
Bladder cancer
Tumor markers
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spelling Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancerCarrasco, RaquelIngelmo-Torres, MercedesGómez, AscensiónRoldán, Fiorella L.Segura, NataliaRibal, María JoséAlcaraz Asensio, AntonioIzquierdo Reyes, LauraMengual Brichs, LourdesPronòstic mèdicUrologiaCàncer de bufetaMarcadors tumoralsPrognosisUrologyBladder cancerTumor markersPurpose: Current clinical prognostic factors are not accurate enough to identify and monitor those muscle-invasive bladder cancer (MIBC) patients at high risk of progression after radical cystectomy (RC). Here, we determined genetic alterations in the tumor and circulating tumor cell (CTC) enumeration to find biomarkers useful for the management of MIBC after RC. Methods: Thirty-nine MIBC patients undergoing RC were included. Tumoral tissue DNA was analyzed by next generation sequencing. CTCs were isolated from blood collected before RC and one, four and 12 months later. Results: Sixteen (41%) patients progressed in a median time of 8.5 months and 11 (69%) of these patients harbored the TERT c.-124C > T mutation. All progressive patients harboring the TERT c.-124C > T mutation presented a significant increase in CTC number 12 months after RC compared to those without the mutation. Additionally, CTC number at 12 months was identified as an independent prognostic biomarker for tumor progression and cancer specific survival (CSS). Ten (63%) progressive patients showed an increment of CTC number with a median anticipation period of four months compared with imaging techniques. Conclusions: The TERT c.-124C > T mutation could be considered a biomarker of aggressivity. CTC enumeration is a useful tool for identifying MIBC patients at high risk of progression and CSS after RC and for detecting tumor progression earlier than imaging techniques.Springer Verlag2024202420222024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/214269Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00345-022-04061-9World Journal of Urology, 2022, vol. 40, num.8, p. 2033-2039https://doi.org/10.1007/s00345-022-04061-9cc by (c) Carrasco, Raquel et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2142692026-05-29T05:05:01Z
dc.title.none.fl_str_mv Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
title Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
spellingShingle Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
Carrasco, Raquel
Pronòstic mèdic
Urologia
Càncer de bufeta
Marcadors tumorals
Prognosis
Urology
Bladder cancer
Tumor markers
title_short Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
title_full Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
title_fullStr Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
title_full_unstemmed Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
title_sort Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
dc.creator.none.fl_str_mv Carrasco, Raquel
Ingelmo-Torres, Mercedes
Gómez, Ascensión
Roldán, Fiorella L.
Segura, Natalia
Ribal, María José
Alcaraz Asensio, Antonio
Izquierdo Reyes, Laura
Mengual Brichs, Lourdes
author Carrasco, Raquel
author_facet Carrasco, Raquel
Ingelmo-Torres, Mercedes
Gómez, Ascensión
Roldán, Fiorella L.
Segura, Natalia
Ribal, María José
Alcaraz Asensio, Antonio
Izquierdo Reyes, Laura
Mengual Brichs, Lourdes
author_role author
author2 Ingelmo-Torres, Mercedes
Gómez, Ascensión
Roldán, Fiorella L.
Segura, Natalia
Ribal, María José
Alcaraz Asensio, Antonio
Izquierdo Reyes, Laura
Mengual Brichs, Lourdes
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pronòstic mèdic
Urologia
Càncer de bufeta
Marcadors tumorals
Prognosis
Urology
Bladder cancer
Tumor markers
topic Pronòstic mèdic
Urologia
Càncer de bufeta
Marcadors tumorals
Prognosis
Urology
Bladder cancer
Tumor markers
description Purpose: Current clinical prognostic factors are not accurate enough to identify and monitor those muscle-invasive bladder cancer (MIBC) patients at high risk of progression after radical cystectomy (RC). Here, we determined genetic alterations in the tumor and circulating tumor cell (CTC) enumeration to find biomarkers useful for the management of MIBC after RC. Methods: Thirty-nine MIBC patients undergoing RC were included. Tumoral tissue DNA was analyzed by next generation sequencing. CTCs were isolated from blood collected before RC and one, four and 12 months later. Results: Sixteen (41%) patients progressed in a median time of 8.5 months and 11 (69%) of these patients harbored the TERT c.-124C > T mutation. All progressive patients harboring the TERT c.-124C > T mutation presented a significant increase in CTC number 12 months after RC compared to those without the mutation. Additionally, CTC number at 12 months was identified as an independent prognostic biomarker for tumor progression and cancer specific survival (CSS). Ten (63%) progressive patients showed an increment of CTC number with a median anticipation period of four months compared with imaging techniques. Conclusions: The TERT c.-124C > T mutation could be considered a biomarker of aggressivity. CTC enumeration is a useful tool for identifying MIBC patients at high risk of progression and CSS after RC and for detecting tumor progression earlier than imaging techniques.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214269
url https://hdl.handle.net/2445/214269
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00345-022-04061-9
World Journal of Urology, 2022, vol. 40, num.8, p. 2033-2039
https://doi.org/10.1007/s00345-022-04061-9
dc.rights.none.fl_str_mv cc by (c) Carrasco, Raquel et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Carrasco, Raquel et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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