Lysosomal cell death mechanisms in aging

25 p.-4 fig.

Bibliographic Details
Authors: Gómez-Sintes, Raquel, Ledesma, M. Dolores, Boya, Patricia
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/151084
Online Access:http://hdl.handle.net/10261/151084
Access Level:Open access
Keyword:Aging
Autophagy
Cathepsins
Lipids
Lysosomal cell death
Lysosomal membrane permeabilization
Lysosomes
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spelling Lysosomal cell death mechanisms in agingGómez-Sintes, RaquelLedesma, M. DoloresBoya, PatriciaAgingAutophagyCathepsinsLipidsLysosomal cell deathLysosomal membrane permeabilizationLysosomes25 p.-4 fig.Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety of processes, from calcium signaling and nutrient responses to autophagic degradation of intracellular components. Lysosomal cell death is mediated by the lethal effects of cathepsins, which are released into the cytoplasm following lysosomal damage. This process of lysosomal membrane permeabilization and cathepsin release is observed in several physiopathological conditions and plays a role in tissue remodeling, the immune response to intracellular pathogens and neurodegenerative diseases. Many evidences indicate that aging strongly influences lysosomal activity by altering the physical and chemical properties of these organelles, rendering them more sensitive to stress. In this review we focus on how aging alters lysosomal function and increases cell sensitivity to lysosomal membrane permeabilization and lysosomal cell death, both in physiological conditions and age-related pathologies.Work in our laboratories is supported by grants from MINECO Consolider CSD2010-00045 to PB and MDL, SAF2012-36079 to PB and SAF2014-57539-R to MDL.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201720172016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/151084reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-57539-Rhttp://dx.doi.org/10.1016/j.arr.2016.02.009Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1510842026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lysosomal cell death mechanisms in aging
title Lysosomal cell death mechanisms in aging
spellingShingle Lysosomal cell death mechanisms in aging
Gómez-Sintes, Raquel
Aging
Autophagy
Cathepsins
Lipids
Lysosomal cell death
Lysosomal membrane permeabilization
Lysosomes
title_short Lysosomal cell death mechanisms in aging
title_full Lysosomal cell death mechanisms in aging
title_fullStr Lysosomal cell death mechanisms in aging
title_full_unstemmed Lysosomal cell death mechanisms in aging
title_sort Lysosomal cell death mechanisms in aging
dc.creator.none.fl_str_mv Gómez-Sintes, Raquel
Ledesma, M. Dolores
Boya, Patricia
author Gómez-Sintes, Raquel
author_facet Gómez-Sintes, Raquel
Ledesma, M. Dolores
Boya, Patricia
author_role author
author2 Ledesma, M. Dolores
Boya, Patricia
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aging
Autophagy
Cathepsins
Lipids
Lysosomal cell death
Lysosomal membrane permeabilization
Lysosomes
topic Aging
Autophagy
Cathepsins
Lipids
Lysosomal cell death
Lysosomal membrane permeabilization
Lysosomes
description 25 p.-4 fig.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/151084
url http://hdl.handle.net/10261/151084
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-57539-R
http://dx.doi.org/10.1016/j.arr.2016.02.009
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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