Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices

The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites e...

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Autores: Sergi, Pier Nicola|||0000-0002-7872-1591, Del Valle, Jaume|||0000-0002-6703-8244, Stieglitz, Thomas|||0000-0002-7349-4254, Navarro, X. (Xavier)|||0000-0001-9849-902X, Micera, Silvestro|||0000-0003-4396-8217
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:308169
Acceso en línea:https://ddd.uab.cat/record/308169
https://dx.doi.org/urn:doi:10.3390/app142210741
Access Level:acceso abierto
Palabra clave:Neural implants
Foreign body reaction
Scar tissue
Peripheral nerves
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spelling Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C DevicesSergi, Pier Nicola|||0000-0002-7872-1591Del Valle, Jaume|||0000-0002-6703-8244Stieglitz, Thomas|||0000-0002-7349-4254Navarro, X. (Xavier)|||0000-0001-9849-902XMicera, Silvestro|||0000-0003-4396-8217Neural implantsForeign body reactionScar tissuePeripheral nervesThe implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data ((Formula presented.)), definitely improving on previous approaches.Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/308169https://dx.doi.org/urn:doi:10.3390/app142210741reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 101099366open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3081692026-06-06T12:50:31Z
dc.title.none.fl_str_mv Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
title Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
spellingShingle Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
Sergi, Pier Nicola|||0000-0002-7872-1591
Neural implants
Foreign body reaction
Scar tissue
Peripheral nerves
title_short Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
title_full Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
title_fullStr Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
title_full_unstemmed Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
title_sort Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
dc.creator.none.fl_str_mv Sergi, Pier Nicola|||0000-0002-7872-1591
Del Valle, Jaume|||0000-0002-6703-8244
Stieglitz, Thomas|||0000-0002-7349-4254
Navarro, X. (Xavier)|||0000-0001-9849-902X
Micera, Silvestro|||0000-0003-4396-8217
author Sergi, Pier Nicola|||0000-0002-7872-1591
author_facet Sergi, Pier Nicola|||0000-0002-7872-1591
Del Valle, Jaume|||0000-0002-6703-8244
Stieglitz, Thomas|||0000-0002-7349-4254
Navarro, X. (Xavier)|||0000-0001-9849-902X
Micera, Silvestro|||0000-0003-4396-8217
author_role author
author2 Del Valle, Jaume|||0000-0002-6703-8244
Stieglitz, Thomas|||0000-0002-7349-4254
Navarro, X. (Xavier)|||0000-0001-9849-902X
Micera, Silvestro|||0000-0003-4396-8217
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
dc.subject.none.fl_str_mv Neural implants
Foreign body reaction
Scar tissue
Peripheral nerves
topic Neural implants
Foreign body reaction
Scar tissue
Peripheral nerves
description The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data ((Formula presented.)), definitely improving on previous approaches.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/308169
https://dx.doi.org/urn:doi:10.3390/app142210741
url https://ddd.uab.cat/record/308169
https://dx.doi.org/urn:doi:10.3390/app142210741
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 101099366
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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