Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occ...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:268757 |
| Acceso en línea: | https://ddd.uab.cat/record/268757 https://dx.doi.org/urn:doi:10.1186/s13075-022-02942-3 |
| Access Level: | acceso abierto |
| Palabra clave: | Functional MRI Pain sensitization Fibromyalgia Knee osteoarthritis Somatosensory cortex Insular cortex |
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Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patientsPujol Nuez, Jesús|||0000-0002-9946-4547Blanco Hinojo, Laura, 1981-Doreste Soler, Andrea|||0000-0002-7213-2550Ojeda, Fabiola|||0000-0002-6734-9288Martinez Vilavella, Gerard|||0000-0001-8948-4918Pérez Solà, Víctor|||0000-0002-5825-2337Deus Yela, Juan|||0000-0002-3305-2662Monfort, Jordi|||0000-0002-9103-661XFunctional MRIPain sensitizationFibromyalgiaKnee osteoarthritisSomatosensory cortexInsular cortexPain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occur in fibromyalgia with no apparent origin. We investigated the distinct functional repercussion of pain sensitization in the cerebral cortex in both conditions. Thirty-one pain-sensitized knee osteoarthritis patients and 38 fibromyalgia patients were compared with matched control groups. And new samples of 34 sensitized knee osteoarthritis and 63 fibromyalgia patients were used to directly compare each condition. A combined measure of local functional connectivity was estimated to map functional alterations in the cerebral cortex at rest. In osteoarthritis, weaker local connectivity was identified in the insula, which is a cortical area processing important aspects of the brain response to painful stimulation. In contrast, fibromyalgia patients showed weaker connectivity in the sensorimotor cortex extensively affecting the cortical representation of the body. In osteoarthritis, weaker insular cortex connectivity is compatible with reduced neural activity during metabolic recovery after repeated activation. In the fibromyalgia neurophysiological context, weaker connectivity may better express both reduced neural activity and increased excitability, particularly affecting the sensorimotor cortex in patients with spontaneous body pain. Such a combination is compatible with a central gain enhancement mechanism, where low sensory tolerance results from the over-amplification of central sensory reception to compensate a presumably weak sensory input. We propose that deficient proprioception could be a factor contributing to weak sensory input. The online version contains supplementary material available at 10.1186/s13075-022-02942-3. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/268757https://dx.doi.org/urn:doi:10.1186/s13075-022-02942-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2687572026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| title |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| spellingShingle |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients Pujol Nuez, Jesús|||0000-0002-9946-4547 Functional MRI Pain sensitization Fibromyalgia Knee osteoarthritis Somatosensory cortex Insular cortex |
| title_short |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| title_full |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| title_fullStr |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| title_full_unstemmed |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| title_sort |
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients |
| dc.creator.none.fl_str_mv |
Pujol Nuez, Jesús|||0000-0002-9946-4547 Blanco Hinojo, Laura, 1981- Doreste Soler, Andrea|||0000-0002-7213-2550 Ojeda, Fabiola|||0000-0002-6734-9288 Martinez Vilavella, Gerard|||0000-0001-8948-4918 Pérez Solà, Víctor|||0000-0002-5825-2337 Deus Yela, Juan|||0000-0002-3305-2662 Monfort, Jordi|||0000-0002-9103-661X |
| author |
Pujol Nuez, Jesús|||0000-0002-9946-4547 |
| author_facet |
Pujol Nuez, Jesús|||0000-0002-9946-4547 Blanco Hinojo, Laura, 1981- Doreste Soler, Andrea|||0000-0002-7213-2550 Ojeda, Fabiola|||0000-0002-6734-9288 Martinez Vilavella, Gerard|||0000-0001-8948-4918 Pérez Solà, Víctor|||0000-0002-5825-2337 Deus Yela, Juan|||0000-0002-3305-2662 Monfort, Jordi|||0000-0002-9103-661X |
| author_role |
author |
| author2 |
Blanco Hinojo, Laura, 1981- Doreste Soler, Andrea|||0000-0002-7213-2550 Ojeda, Fabiola|||0000-0002-6734-9288 Martinez Vilavella, Gerard|||0000-0001-8948-4918 Pérez Solà, Víctor|||0000-0002-5825-2337 Deus Yela, Juan|||0000-0002-3305-2662 Monfort, Jordi|||0000-0002-9103-661X |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Functional MRI Pain sensitization Fibromyalgia Knee osteoarthritis Somatosensory cortex Insular cortex |
| topic |
Functional MRI Pain sensitization Fibromyalgia Knee osteoarthritis Somatosensory cortex Insular cortex |
| description |
Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occur in fibromyalgia with no apparent origin. We investigated the distinct functional repercussion of pain sensitization in the cerebral cortex in both conditions. Thirty-one pain-sensitized knee osteoarthritis patients and 38 fibromyalgia patients were compared with matched control groups. And new samples of 34 sensitized knee osteoarthritis and 63 fibromyalgia patients were used to directly compare each condition. A combined measure of local functional connectivity was estimated to map functional alterations in the cerebral cortex at rest. In osteoarthritis, weaker local connectivity was identified in the insula, which is a cortical area processing important aspects of the brain response to painful stimulation. In contrast, fibromyalgia patients showed weaker connectivity in the sensorimotor cortex extensively affecting the cortical representation of the body. In osteoarthritis, weaker insular cortex connectivity is compatible with reduced neural activity during metabolic recovery after repeated activation. In the fibromyalgia neurophysiological context, weaker connectivity may better express both reduced neural activity and increased excitability, particularly affecting the sensorimotor cortex in patients with spontaneous body pain. Such a combination is compatible with a central gain enhancement mechanism, where low sensory tolerance results from the over-amplification of central sensory reception to compensate a presumably weak sensory input. We propose that deficient proprioception could be a factor contributing to weak sensory input. The online version contains supplementary material available at 10.1186/s13075-022-02942-3. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/268757 https://dx.doi.org/urn:doi:10.1186/s13075-022-02942-3 |
| url |
https://ddd.uab.cat/record/268757 https://dx.doi.org/urn:doi:10.1186/s13075-022-02942-3 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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