An oncospace for human cancers

Human cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity of organisms, one can conjecture that there is order in...

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Detalles Bibliográficos
Autores: Aguadé Gorgorió, Guim, 1991-, Costa, José, Solé Vicente, Ricard, 1962-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/56843
Acceso en línea:http://hdl.handle.net/10230/56843
http://dx.doi.org/10.1002/bies.202200215
Access Level:acceso abierto
Palabra clave:Cancer morphospace
Developmental abnormalities
Genome instability
Microenvironmental complexity
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spelling An oncospace for human cancersAguadé Gorgorió, Guim, 1991-Costa, JoséSolé Vicente, Ricard, 1962-Cancer morphospaceDevelopmental abnormalitiesGenome instabilityMicroenvironmental complexityHuman cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity of organisms, one can conjecture that there is order in the cancer multiverse. Is there a way to capture the broad range of tumor types within a space of the possible? Here we define the oncospace, a coordinate system that integrates the ecological, evolutionary and developmental components of cancer complexity. The spatial position of a tumor results from its departure from the healthy tissue along these three axes, and progression trajectories inform about the components driving malignancy across cancer subtypes. We postulate that the oncospace topology encodes new information regarding tumorigenic pathways, subtype prognosis, and therapeutic opportunities: treatment design could benefit from considering how to nudge tumors toward empty evolutionary dead ends in the oncospace.This work was supported by the Botı́n Foundation by Banco Santander through its Santander Universities Global Division, the Spanish Ministry of Economy and Competitiveness, grant FIS2016-77447-R MINECO/AEI/FEDER, a Postdoctoral Fellowship 2022 of the Fundación Ramón Areces, an AGAUR FI 2018 grant, and the Santa Fe Institute.Wiley202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56843http://dx.doi.org/10.1002/bies.202200215reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBioessays. 2023 May;45(5):e2200215info:eu-repo/grantAgreement/ES/1PE/FIS2016-77447-R© 2023 The Authors. BioEssays published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/568432026-05-29T05:05:01Z
dc.title.none.fl_str_mv An oncospace for human cancers
title An oncospace for human cancers
spellingShingle An oncospace for human cancers
Aguadé Gorgorió, Guim, 1991-
Cancer morphospace
Developmental abnormalities
Genome instability
Microenvironmental complexity
title_short An oncospace for human cancers
title_full An oncospace for human cancers
title_fullStr An oncospace for human cancers
title_full_unstemmed An oncospace for human cancers
title_sort An oncospace for human cancers
dc.creator.none.fl_str_mv Aguadé Gorgorió, Guim, 1991-
Costa, José
Solé Vicente, Ricard, 1962-
author Aguadé Gorgorió, Guim, 1991-
author_facet Aguadé Gorgorió, Guim, 1991-
Costa, José
Solé Vicente, Ricard, 1962-
author_role author
author2 Costa, José
Solé Vicente, Ricard, 1962-
author2_role author
author
dc.subject.none.fl_str_mv Cancer morphospace
Developmental abnormalities
Genome instability
Microenvironmental complexity
topic Cancer morphospace
Developmental abnormalities
Genome instability
Microenvironmental complexity
description Human cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity of organisms, one can conjecture that there is order in the cancer multiverse. Is there a way to capture the broad range of tumor types within a space of the possible? Here we define the oncospace, a coordinate system that integrates the ecological, evolutionary and developmental components of cancer complexity. The spatial position of a tumor results from its departure from the healthy tissue along these three axes, and progression trajectories inform about the components driving malignancy across cancer subtypes. We postulate that the oncospace topology encodes new information regarding tumorigenic pathways, subtype prognosis, and therapeutic opportunities: treatment design could benefit from considering how to nudge tumors toward empty evolutionary dead ends in the oncospace.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/56843
http://dx.doi.org/10.1002/bies.202200215
url http://hdl.handle.net/10230/56843
http://dx.doi.org/10.1002/bies.202200215
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bioessays. 2023 May;45(5):e2200215
info:eu-repo/grantAgreement/ES/1PE/FIS2016-77447-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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