Kinetics of Procalcitonin in Pediatric Patients on Extracorporeal Membrane Oxygenation.
OBJECTIVES: To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in pediatric patients who required extracorporeal membrane oxygenation (ECMO) and to analyze its relationship with morbidity and mortality. PATIENTS AND METHODS: Prospective observational study including pediatric...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p13462 |
| Acceso en línea: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13462 |
| Access Level: | acceso abierto |
| Palabra clave: | C-reactive protein ECMO infection multiple organ dysfunction syndrome outcome procalcitonin |
| Sumario: | OBJECTIVES: To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in pediatric patients who required extracorporeal membrane oxygenation (ECMO) and to analyze its relationship with morbidity and mortality. PATIENTS AND METHODS: Prospective observational study including pediatric patients who required ECMO. Both PCT and CRP were sequentially drawn before ECMO (P0) and until 72hours after ECMO. RESULTS: A total of 40 patients were recruited. Two cohorts were established based on the value of the P0 PCT (>10ng/mL). Comparing the kinetics of PCT and CRP in these cohorts, the described curves were the expected for each clinical situation. The cutoff for P0 PCT to predict multiple organ dysfunction syndrome was 2.55ng/mL (sensibility 83%, specificity 100%). Both PCT and CRP did not predict risk of neurologic sequelae or mortality in any group. CONCLUSIONS: Procalcitonin does not seem to be modified by ECMO and could be a good biomarker of evolution. |
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