Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults

Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people ≥65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016,...

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Autores: Ciruela, Pilar, Broner, Sonia, Izquierdo, Conchita, Pallarés Giner, Roman, Muñoz-Almagro, Carmen, Hernandez, Sergi, Grau, Immaculada, Domínguez García, Àngela, Jané, Mireia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/161441
Acesso em linha:https://hdl.handle.net/2445/161441
Access Level:acceso abierto
Palavra-chave:Infeccions per pneumococs
Vacunació
Mortalitat
Meningitis cerebrospinal epidèmica
Pneumococcal Infections
Vaccination
Mortality
Cerebrospinal meningitis
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repository_id_str
spelling Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adultsCiruela, PilarBroner, SoniaIzquierdo, ConchitaPallarés Giner, RomanMuñoz-Almagro, CarmenHernandez, SergiGrau, ImmaculadaDomínguez García, ÀngelaJané, MireiaInfeccions per pneumococsVacunacióMortalitatMeningitis cerebrospinal epidèmicaPneumococcal InfectionsVaccinationMortalityCerebrospinal meningitisObjectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people ≥65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age ≥85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and ≥1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people ≥65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, ≥1 high-risk condition, and PCV13 serotypes.Elsevier B.V.2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/161441Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.ijid.2019.06.030International Journal of Infectious Diseases, 2019, vol. 86, p. 122-130https://doi.org/10.1016/j.ijid.2019.06.030http://dx.doi.org/10.1016/j.ijid.2019.12.027cc-by-nc-nd (c) Ciruela, Pilar et al., 2019http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1614412026-05-27T06:46:51Z
dc.title.none.fl_str_mv Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
spellingShingle Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
Ciruela, Pilar
Infeccions per pneumococs
Vacunació
Mortalitat
Meningitis cerebrospinal epidèmica
Pneumococcal Infections
Vaccination
Mortality
Cerebrospinal meningitis
title_short Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_full Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_fullStr Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_full_unstemmed Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_sort Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
dc.creator.none.fl_str_mv Ciruela, Pilar
Broner, Sonia
Izquierdo, Conchita
Pallarés Giner, Roman
Muñoz-Almagro, Carmen
Hernandez, Sergi
Grau, Immaculada
Domínguez García, Àngela
Jané, Mireia
author Ciruela, Pilar
author_facet Ciruela, Pilar
Broner, Sonia
Izquierdo, Conchita
Pallarés Giner, Roman
Muñoz-Almagro, Carmen
Hernandez, Sergi
Grau, Immaculada
Domínguez García, Àngela
Jané, Mireia
author_role author
author2 Broner, Sonia
Izquierdo, Conchita
Pallarés Giner, Roman
Muñoz-Almagro, Carmen
Hernandez, Sergi
Grau, Immaculada
Domínguez García, Àngela
Jané, Mireia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infeccions per pneumococs
Vacunació
Mortalitat
Meningitis cerebrospinal epidèmica
Pneumococcal Infections
Vaccination
Mortality
Cerebrospinal meningitis
topic Infeccions per pneumococs
Vacunació
Mortalitat
Meningitis cerebrospinal epidèmica
Pneumococcal Infections
Vaccination
Mortality
Cerebrospinal meningitis
description Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people ≥65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age ≥85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and ≥1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people ≥65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, ≥1 high-risk condition, and PCV13 serotypes.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/161441
url https://hdl.handle.net/2445/161441
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2019.06.030
International Journal of Infectious Diseases, 2019, vol. 86, p. 122-130
https://doi.org/10.1016/j.ijid.2019.06.030
http://dx.doi.org/10.1016/j.ijid.2019.12.027
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Ciruela, Pilar et al., 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Ciruela, Pilar et al., 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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