Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia

We investigated the influence of 55 583 autophagy-related single-nucleotide polymorphisms (SNPs) on chronic lymphocytic leukemia (CLL) risk across 4 independent populations comprising 5472 CLL cases and 726 465 controls. We also examined their impact on overall survival (OS), time to first treatment...

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Detalles Bibliográficos
Autores: Cabrera Serrano, Antonio José, Sánchez Maldonado, José Manuel, Rodríguez Sevilla, Juan José, Reyes-Zurita, Fernando Jesús, Collado, Rosa, Puiggros, Anna, Cornejo-Calvo, Elena, García-Martín, Paloma, Ter Horst, Rob, Benavente, Yolanda, Jerez, Andrés, Landi, Stefano, Espinet, Blanca, Maffei, Rossana, López-Nevot, Miguel Ángel, Ramos-Campoy, Silvia, González-Olmedo, Carmen, Chen-Liang, Tzu-Hua, Moreno, Víctor, Jannus, Fatin, Marcos-Gragera, Rafael, Carretero-Fernández, María, Sampaio-Marques, Belém, Gámez, Irene, García-Alvarez, María, Camp, Nicola J., Dierssen-Sotos, Trinidad, Kamaso, Joanna, Pérez, Eva María, Norman, Aaron D., Luppi, Mario, Li, Yang, Alcoceba, Miguel, Campa, Daniele, San José, Silvia de, Marasca, Roberto, Ludovico, Paula, Clay-Gilmour, Alyssa, Canzian, Federico, Ibañez, Marian, Netea, Mihai G., McKay, James, Casabonne, Delphine, Berndt, Sonja I., Slager, Susan L., Sainz, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/425053
Acceso en línea:http://hdl.handle.net/10261/425053
https://api.elsevier.com/content/abstract/scopus_id/105022659497
Access Level:acceso abierto
Palabra clave:Health Services and Outcomes
Lymphoid Neoplasia
Descripción
Sumario:We investigated the influence of 55 583 autophagy-related single-nucleotide polymorphisms (SNPs) on chronic lymphocytic leukemia (CLL) risk across 4 independent populations comprising 5472 CLL cases and 726 465 controls. We also examined their impact on overall survival (OS), time to first treatment (TTFT), autophagy flux, and immune responses. A meta-analysis of the 4 populations identified, to our knowledge, for the first time, significant associations between CDKN2A (rs3731204) and BCL2 (rs4940571, rs12457371, and rs1026825) SNPs and CLL risk, with CDKN2A showing the strongest association (P = 1.57 × 10−12). We also validated previously reported associations for FAS, BCL2, and BAK1 SNPs with CLL risk (P = 4.73 × 10−21 to 3.39 × 10−9). The CDKN2Ars3731204 and FASrs1926194 SNPs associated with increased CDKN2A and ACTA2 messenger RNA expression levels in the whole blood and/or lymphocytes (P = 5.1 × 10−7, P = 1.58 × 10−21, and P = 7.8 × 10−41), although no significant effect on autophagy flux was observed. However, associations were found between CDKN2A, BCL2, and FAS SNPs and various T-cell subsets, cytokine production, and circulating concentrations of interferon gamma, tumor necrosis factor–related apoptosis-inducing ligand, CD40, chemokine ligand 20, and interleukin-2 receptor subunit β proteins (P ≤ .005). No significant association was detected between autophagy variants and OS or TTFT, suggesting that these variants drive disease initiation rather than progression. In conclusion, this study identified 4 novel associations for CLL and provided insights into the biological pathways that influence CLL development.

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