Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study).

Background: Geographical variations in the frequency of oncogenic driver alterations in non-small cell lung cancer (NSCLC) are observed worldwide, likely influenced by genetic and environmental factors. Radon, a leading cause of lung cancer in nonsmokers, may influence NSCLC's molecular profile...

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Detalles Bibliográficos
Autores: García Pardo, Miguel, García de Herreros, Marta, Auclin, Edouard, Ferriol Galmes, Miquel, Laguna Egea, Juan Carlos, Gorría, Teresa, Caravaca, Gerard, Sart, Joan, Albarrán Artahona, Víctor, López Castro, Rafael, Teixidó Febrero, Cristina, Castellano, Giancarlo, Martínez Bedmar, Alex, Arcocha, Ainara, Alcolea, Laura, Jiménez, Manuel, Bernabeu, Mario, Delgado Cano, David, Navarro, Alejandro, Prat Aparicio, Aleix, Reguart, Noemí, Elio, Javier, Garrido, Pilar, Leighl, Natasha B., Besse, Benjamin, Mezquita, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226172
Acceso en línea:https://hdl.handle.net/2445/226172
Access Level:acceso abierto
Palabra clave:Càncer de pulmó
Radó
Genòmica
Lung cancer
Radon
Genomics
Descripción
Sumario:Background: Geographical variations in the frequency of oncogenic driver alterations in non-small cell lung cancer (NSCLC) are observed worldwide, likely influenced by genetic and environmental factors. Radon, a leading cause of lung cancer in nonsmokers, may influence NSCLC's molecular profile. Objectives: This study aims to explore the potential correlation between estimated indoor radon concentrations and the frequency of driver alterations in NSCLC across Europe. Design: Ecological study of European countries with available data on indoor radon exposure (estimated mean levels and the proportion (%) of dwellings with concentrations >200 and >400 Bq/m3), and frequency of NSCLC actionable genomic alterations (EGFR, ALK) from PubMed articles and meeting abstracts with sample size >100 patients. Methods: We retrospectively analyzed NSCLC molecular data and radon exposure levels from European countries. Radon data, including the mean and proportion (%) of dwellings with concentrations >200 and >400 Bq/m3, were sourced from the European Commission Report 2005. NSCLC molecular alteration frequency (EGFR, ALK) was extracted from PubMed articles with sample sizes >100 patients. The correlation between molecular alteration frequencies and country-specific radon data were assessed. Results: Data on radon exposure and EGFR/ALK frequency were available for 21 European countries. Five countries had mean radon levels >100 Bq/m3, and eight countries had ⩾3% of dwellings with concentrations >400 Bq/m3. The median frequency of EGFR mutations and ALK fusions was 11.3% (range 7%-18.1%) and 4.1% (range 3.4%-12%), respectively. A positive correlation was found between estimated ALK-fusion frequency and the percentage of dwellings with >400 Bq/m3 (r = 0.72, p = 0.001). No correlation was found between EGFR mutation frequency and radon exposure. Conclusion: We found a positive correlation between estimated ALK fusion frequency in NSCLC and the proportion of dwellings exceeding 400 Bq/m3 radon exposure in 21 European countries. Further research is needed to explore the potential influence of radon and other environmental factors on NSCLC with driver alterations.

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