Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy

Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for Enterococcus faecalis infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy...

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Autores: Fernández Rubio, Beatriz, Herrera Hidalgo, Laura, Luque Márquez, Rafael, Alarcón, Arístides de, López-Cortés, Luis E., Luque Pardos, Sònia, Gutiérrez Urbón, José María, Fernández Polo, Antoni, Gil Navarro, María V., Gutiérrez Valencia, Alicia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/59879
Acceso en línea:http://hdl.handle.net/10230/59879
http://dx.doi.org/10.3390/antibiotics12030432
Access Level:acceso abierto
Palabra clave:Stability
Outpatient parenteral antimicrobial therapy
Elastomers
Ampicillin
Ceftriaxone
Infective endocarditis
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spelling Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapyFernández Rubio, BeatrizHerrera Hidalgo, LauraLuque Márquez, RafaelAlarcón, Arístides deLópez-Cortés, Luis E.Luque Pardos, SòniaGutiérrez Urbón, José MaríaFernández Polo, AntoniGil Navarro, María V.Gutiérrez Valencia, AliciaStabilityOutpatient parenteral antimicrobial therapyElastomersAmpicillinCeftriaxoneInfective endocarditisCurrently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for Enterococcus faecalis infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy (OPAT) programs is challenging. The objective of the study was to determine the stability of AC in elastomeric pumps when stored at 8 ± 2 °C, 25 ± 2 °C, 30 ± 2 °C and 37 ± 2 °C using LC-MS/MS. The combination was diluted in 0.9% sodium chloride and the final concentrations were ampicillin 24 g/L plus ceftriaxone 8 g/L. Physical and chemical stability were evaluated at 12, 20, 24, 36 and 48 h after preparation. Stability was met at each time point if the percentage of intact drug was ≥90% of its respective baseline concentration and color and clearness remained unchanged. The drug combination was stable for 48 h when it was kept at 8 ± 2 °C. At 25 ± 2 °C and 30 ± 2 °C, they were stable for 24 h of storage. At 37 ± 2 °C, the stability criterion was not met at any time point. These results prove that AC could be included in OPAT programs using elastomeric infusion devices for the treatment of E. faecalis infections.MDPI202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59879http://dx.doi.org/10.3390/antibiotics12030432reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésAntibiotics (Basel). 2023 Feb 22;12(3):432© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/598792026-06-12T07:21:37Z
dc.title.none.fl_str_mv Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
title Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
spellingShingle Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
Fernández Rubio, Beatriz
Stability
Outpatient parenteral antimicrobial therapy
Elastomers
Ampicillin
Ceftriaxone
Infective endocarditis
title_short Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
title_full Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
title_fullStr Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
title_full_unstemmed Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
title_sort Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
dc.creator.none.fl_str_mv Fernández Rubio, Beatriz
Herrera Hidalgo, Laura
Luque Márquez, Rafael
Alarcón, Arístides de
López-Cortés, Luis E.
Luque Pardos, Sònia
Gutiérrez Urbón, José María
Fernández Polo, Antoni
Gil Navarro, María V.
Gutiérrez Valencia, Alicia
author Fernández Rubio, Beatriz
author_facet Fernández Rubio, Beatriz
Herrera Hidalgo, Laura
Luque Márquez, Rafael
Alarcón, Arístides de
López-Cortés, Luis E.
Luque Pardos, Sònia
Gutiérrez Urbón, José María
Fernández Polo, Antoni
Gil Navarro, María V.
Gutiérrez Valencia, Alicia
author_role author
author2 Herrera Hidalgo, Laura
Luque Márquez, Rafael
Alarcón, Arístides de
López-Cortés, Luis E.
Luque Pardos, Sònia
Gutiérrez Urbón, José María
Fernández Polo, Antoni
Gil Navarro, María V.
Gutiérrez Valencia, Alicia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Stability
Outpatient parenteral antimicrobial therapy
Elastomers
Ampicillin
Ceftriaxone
Infective endocarditis
topic Stability
Outpatient parenteral antimicrobial therapy
Elastomers
Ampicillin
Ceftriaxone
Infective endocarditis
description Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for Enterococcus faecalis infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy (OPAT) programs is challenging. The objective of the study was to determine the stability of AC in elastomeric pumps when stored at 8 ± 2 °C, 25 ± 2 °C, 30 ± 2 °C and 37 ± 2 °C using LC-MS/MS. The combination was diluted in 0.9% sodium chloride and the final concentrations were ampicillin 24 g/L plus ceftriaxone 8 g/L. Physical and chemical stability were evaluated at 12, 20, 24, 36 and 48 h after preparation. Stability was met at each time point if the percentage of intact drug was ≥90% of its respective baseline concentration and color and clearness remained unchanged. The drug combination was stable for 48 h when it was kept at 8 ± 2 °C. At 25 ± 2 °C and 30 ± 2 °C, they were stable for 24 h of storage. At 37 ± 2 °C, the stability criterion was not met at any time point. These results prove that AC could be included in OPAT programs using elastomeric infusion devices for the treatment of E. faecalis infections.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/59879
http://dx.doi.org/10.3390/antibiotics12030432
url http://hdl.handle.net/10230/59879
http://dx.doi.org/10.3390/antibiotics12030432
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antibiotics (Basel). 2023 Feb 22;12(3):432
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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