The Role of RNA and RNA-related Proteins in the Regulation of DNA Double Strand Break Repair Pathway Choice
DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation...
| Autores: | , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/166621 |
| Acesso em linha: | https://hdl.handle.net/11441/166621 https://doi.org/10.1016/j.dnarep.2019.102662 |
| Access Level: | acceso abierto |
| Palavra-chave: | DNA double strand break repair Homologous recombination NHEJ R-loops RNA |
| Resumo: | DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation of resection by RNA molecules and RNA-related proteins. Moreover, we aim to reconcile contradictory reports on the positive or negative effect of DNA:RNA hybrids in the resection process. |
|---|