Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?

Uveal melanoma is considered a rare disease but it is the most common intraocular malignancy in adults. Local treatments are effective, but the systemic recurrence rate is unacceptably high. Moreover, once metastasis have developed the prognosis is poor, with a 5-year survival rate of less than 5%,...

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Detalhes bibliográficos
Autores: Castet, Florian, García Mulero, Sandra, Sanz Pamplona, Rebeca, Cuellar, Andres, Casanovas i Casanovas, Oriol, Caminal Mitjana, Josep Maria, Piulats, Josep M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174839
Acesso em linha:https://hdl.handle.net/2445/174839
Access Level:acceso abierto
Palavra-chave:Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Ophthalmopathies
Neovascularization
Immunotherapy
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spelling Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?Castet, FlorianGarcía Mulero, SandraSanz Pamplona, RebecaCuellar, AndresCasanovas i Casanovas, OriolCaminal Mitjana, Josep MariaPiulats, Josep M.MelanomaOftalmopatiesAngiogènesiImmunoteràpiaMelanomaOphthalmopathiesNeovascularizationImmunotherapyUveal melanoma is considered a rare disease but it is the most common intraocular malignancy in adults. Local treatments are effective, but the systemic recurrence rate is unacceptably high. Moreover, once metastasis have developed the prognosis is poor, with a 5-year survival rate of less than 5%, and systemic therapies, including immunotherapy, have rendered poor results. The tumour biology is complex, but angiogenesis is a highly important pathway in these tumours. Vasculogenic mimicry, the ability of melanomas to generate vascular channels independently of endothelial cells, could play an important role, but no effective therapy targeting this process has been developed so far. Angiogenesis modulates the tumour microenvironment of melanomas, and a close interplay is established between them. Therefore, combining immune strategies with drugs targeting angiogenesis offers a new therapeutic paradigm. In preclinical studies, these approaches effectively target these tumours, and a phase I clinical study has shown encouraging results in cutaneous melanomas. In this review, we will discuss the importance of angiogenesis in uveal melanoma, with a special focus on vasculogenic mimicry, and describe the interplay between angiogenesis and the tumour microenvironment. In addition, we will suggest future therapeutic approaches based on these observations and mention ways in which to potentially enhance current treatments.MDPI2021202120192021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22 p.application/pdfhttps://hdl.handle.net/2445/174839Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/cancers11060834Cancers, 2019, vol. 11, num. 6https://doi.org/10.3390/cancers11060834cc by (c) Castet et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1748392026-05-29T05:05:01Z
dc.title.none.fl_str_mv Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
spellingShingle Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
Castet, Florian
Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Melanoma
Ophthalmopathies
Neovascularization
Immunotherapy
title_short Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_full Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_fullStr Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_full_unstemmed Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_sort Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
dc.creator.none.fl_str_mv Castet, Florian
García Mulero, Sandra
Sanz Pamplona, Rebeca
Cuellar, Andres
Casanovas i Casanovas, Oriol
Caminal Mitjana, Josep Maria
Piulats, Josep M.
author Castet, Florian
author_facet Castet, Florian
García Mulero, Sandra
Sanz Pamplona, Rebeca
Cuellar, Andres
Casanovas i Casanovas, Oriol
Caminal Mitjana, Josep Maria
Piulats, Josep M.
author_role author
author2 García Mulero, Sandra
Sanz Pamplona, Rebeca
Cuellar, Andres
Casanovas i Casanovas, Oriol
Caminal Mitjana, Josep Maria
Piulats, Josep M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Melanoma
Ophthalmopathies
Neovascularization
Immunotherapy
topic Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Melanoma
Ophthalmopathies
Neovascularization
Immunotherapy
description Uveal melanoma is considered a rare disease but it is the most common intraocular malignancy in adults. Local treatments are effective, but the systemic recurrence rate is unacceptably high. Moreover, once metastasis have developed the prognosis is poor, with a 5-year survival rate of less than 5%, and systemic therapies, including immunotherapy, have rendered poor results. The tumour biology is complex, but angiogenesis is a highly important pathway in these tumours. Vasculogenic mimicry, the ability of melanomas to generate vascular channels independently of endothelial cells, could play an important role, but no effective therapy targeting this process has been developed so far. Angiogenesis modulates the tumour microenvironment of melanomas, and a close interplay is established between them. Therefore, combining immune strategies with drugs targeting angiogenesis offers a new therapeutic paradigm. In preclinical studies, these approaches effectively target these tumours, and a phase I clinical study has shown encouraging results in cutaneous melanomas. In this review, we will discuss the importance of angiogenesis in uveal melanoma, with a special focus on vasculogenic mimicry, and describe the interplay between angiogenesis and the tumour microenvironment. In addition, we will suggest future therapeutic approaches based on these observations and mention ways in which to potentially enhance current treatments.
publishDate 2019
dc.date.none.fl_str_mv 2019
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174839
url https://hdl.handle.net/2445/174839
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers11060834
Cancers, 2019, vol. 11, num. 6
https://doi.org/10.3390/cancers11060834
dc.rights.none.fl_str_mv cc by (c) Castet et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Castet et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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