Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction
© Mary Ann Liebert, Inc.,
| Autores: | , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/349520 |
| Acceso en línea: | http://hdl.handle.net/10261/349520 https://api.elsevier.com/content/abstract/scopus_id/85167481603 |
| Access Level: | acceso abierto |
| Palabra clave: | Heart failure Heart failure with preserved ejection fraction Triiodothyronine Thyroid hormones Metabolic syndrome Diastolic function |
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Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| title |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| spellingShingle |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction Neves, João Sérgio Heart failure Heart failure with preserved ejection fraction Triiodothyronine Thyroid hormones Metabolic syndrome Diastolic function |
| title_short |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| title_full |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| title_fullStr |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| title_full_unstemmed |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| title_sort |
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction |
| dc.creator.none.fl_str_mv |
Neves, João Sérgio Leite, Ana Rita Conceição, Glória Gonçalves, Alexandre Borges-Canha, Marta Vale, Catarina Von-Hafe, Madalena Martins, Diana Miranda-Silva, Daniela Leite, Sara Rocha-Oliveira, Estela Sousa-Mendes, Cláudia Chaves, Joana Lourenço, Inês Mariana Grijota Martínez, María del Carmen Bárez-López, Soledad Miranda, Isabel M. Almeida-Coelho, João Vasques-Nóvoa, Francisco Carvalho, Davide Lourenço, André Falcão-Pires, Inês Leite-Moreira, Adelino |
| author |
Neves, João Sérgio |
| author_facet |
Neves, João Sérgio Leite, Ana Rita Conceição, Glória Gonçalves, Alexandre Borges-Canha, Marta Vale, Catarina Von-Hafe, Madalena Martins, Diana Miranda-Silva, Daniela Leite, Sara Rocha-Oliveira, Estela Sousa-Mendes, Cláudia Chaves, Joana Lourenço, Inês Mariana Grijota Martínez, María del Carmen Bárez-López, Soledad Miranda, Isabel M. Almeida-Coelho, João Vasques-Nóvoa, Francisco Carvalho, Davide Lourenço, André Falcão-Pires, Inês Leite-Moreira, Adelino |
| author_role |
author |
| author2 |
Leite, Ana Rita Conceição, Glória Gonçalves, Alexandre Borges-Canha, Marta Vale, Catarina Von-Hafe, Madalena Martins, Diana Miranda-Silva, Daniela Leite, Sara Rocha-Oliveira, Estela Sousa-Mendes, Cláudia Chaves, Joana Lourenço, Inês Mariana Grijota Martínez, María del Carmen Bárez-López, Soledad Miranda, Isabel M. Almeida-Coelho, João Vasques-Nóvoa, Francisco Carvalho, Davide Lourenço, André Falcão-Pires, Inês Leite-Moreira, Adelino |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission Fundação para a Ciência e a Tecnologia (Portugal) Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Heart failure Heart failure with preserved ejection fraction Triiodothyronine Thyroid hormones Metabolic syndrome Diastolic function |
| topic |
Heart failure Heart failure with preserved ejection fraction Triiodothyronine Thyroid hormones Metabolic syndrome Diastolic function |
| description |
© Mary Ann Liebert, Inc., |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Postprint info:eu-repo/semantics/acceptedVersion |
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article |
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acceptedVersion |
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http://hdl.handle.net/10261/349520 https://api.elsevier.com/content/abstract/scopus_id/85167481603 |
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http://hdl.handle.net/10261/349520 https://api.elsevier.com/content/abstract/scopus_id/85167481603 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-86342-R Thyroid : official journal of the American Thyroid Association The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1089/thy.2022.0717 http://doi.org/10.1089/thy.2022.0717 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
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Mary Ann Liebert |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869418286449426432 |
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Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection FractionNeves, João SérgioLeite, Ana RitaConceição, GlóriaGonçalves, AlexandreBorges-Canha, MartaVale, CatarinaVon-Hafe, MadalenaMartins, DianaMiranda-Silva, DanielaLeite, SaraRocha-Oliveira, EstelaSousa-Mendes, CláudiaChaves, JoanaLourenço, Inês MarianaGrijota Martínez, María del CarmenBárez-López, SoledadMiranda, Isabel M.Almeida-Coelho, JoãoVasques-Nóvoa, FranciscoCarvalho, DavideLourenço, AndréFalcão-Pires, InêsLeite-Moreira, AdelinoHeart failureHeart failure with preserved ejection fractionTriiodothyronineThyroid hormonesMetabolic syndromeDiastolic function© Mary Ann Liebert, Inc.,[Background]: Low levels of triiodothyronine (T3) are common in patients with heart failure (HF). Our aim was to evaluate the effects of supplementation with low and replacement doses of T3 in an animal model of HF with preserved ejection fraction (HFpEF).[Methods]: We evaluated four groups: ZSF1 Lean (n = 8, Lean-Ctrl), ZSF1 Obese (rat model of metabolic-induced HFpEF, n = 13, HFpEF), ZSF1 Obese treated with a replacement dose of T3 (n = 8, HFpEF-T3high), and ZSF1 Obese treated with a low-dose of T3 (n = 8, HFpEF-T3low). T3 was administered in drinking water from weeks 13 to 24. The animals underwent anthropometric and metabolic assessments, echocardiography, and peak effort testing with maximum O2 consumption (VO2max) determination at 22 weeks, and a terminal hemodynamic evaluation at 24 weeks. Afterwhile myocardial samples were collected for single cardiomyocyte evaluation and molecular studies.[Results]: HFpEF animals showed lower serum and myocardial thyroid hormone levels than Lean-Ctrl. Treatment with T3 did not normalize serum T3 levels, but increased myocardial T3 levels to normal levels in the HFpEF-T3high group. Body weight was significantly decreased in both the T3-treated groups, comparing with HFpEF. An improvement in glucose metabolism was observed only in HFpEF-T3high. Both the treated groups had improved diastolic and systolic function in vivo, as well as improved Ca2+ transients and sarcomere shortening and relaxation in vitro. Comparing with HFpEF animals, HFpEF-T3high had increased heart rate and a higher rate of premature ventricular contractions. Animals treated with T3 had higher myocardial expression of calcium transporter ryanodine receptor 2 (RYR2) and α-myosin heavy chain (MHC), with a lower expression of β-MHC. VO2max was not influenced by treatment with T3. Myocardial fibrosis was reduced in both the treated groups. Three animals died in the HFpEF-T3high group.[Conclusions]: Treatment with T3 was shown to improve metabolic profile, myocardial calcium handling, and cardiac function. While the low dose was well-tolerated and safe, the replacement dose was associated with increased heart rate, and increased risk of arrhythmias and sudden death. Modulation of thyroid hormones may be a potential therapeutic target in HFpEF; however, it is important to take into account the narrow therapeutic window of T3 in this condition.This study was supported by grants from the European Union (FP7-HEALTH-2010-MEDIA), and national funds through FCT—Portuguese Foundation for Science and Technology (UIDB/00051/2020, UIDP/00051/2020, 2021. 06947.BD., PTDC/DTP-PIC/4104/2014, NORTE-01-0145-FEDER-000003-DocNET, SAICT-PAC/0047/2015, and 01/ 12/2016-NETDIAMOND) and the Spanish Ministry of Science and Innovation (MCIN)/AEI/10.13039/501100011033 (Grant No. SAF2017-86342-R).Peer reviewedMary Ann LiebertEuropean CommissionFundação para a Ciência e a Tecnologia (Portugal)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/349520https://api.elsevier.com/content/abstract/scopus_id/85167481603reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-86342-RThyroid : official journal of the American Thyroid AssociationThe underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1089/thy.2022.0717http://doi.org/10.1089/thy.2022.0717Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3495202026-05-22T06:33:51Z |
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15,812429 |