Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network

GEIDIS is a national-based research-net registry of patients with bronchopulmonary dysplasia (BPD) from public and private Spanish hospitals. It was created to provide data on the clinical characterization and follow-up of infants with BPD until adulthood. The purpose of this observational study was...

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Autores: Ramos-Navarro, Cristina, Maderuelo-Rodríguez, Elena, Concheiro-Guisán, Ana, Pérez-Tarazona, Santiago, Rueda-Esteban, Santiago, Sánchez-Torres, Ana, Sánchez-Solís, Manuel, Sanz-López, Ester, Sánchez-Luna, Manuel, Andrés Martín, Anselmo, Delgado Pecellín, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/139520
Acceso en línea:https://hdl.handle.net/11441/139520
https://doi.org/10.1007/s00431-021-04248-z
Access Level:acceso abierto
Palabra clave:Bronchopulmonary dysplasia
GEIDIS network
Preterm infants
Mechanical ventilation
Intrauterine growth restriction
Oligohydramnios
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network_name_str España
repository_id_str
spelling Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research NetworkRamos-Navarro, CristinaMaderuelo-Rodríguez, ElenaConcheiro-Guisán, AnaPérez-Tarazona, SantiagoRueda-Esteban, SantiagoSánchez-Torres, AnaSánchez-Solís, ManuelSanz-López, EsterSánchez-Luna, ManuelAndrés Martín, AnselmoDelgado Pecellín, IsabelBronchopulmonary dysplasiaGEIDIS networkPreterm infantsMechanical ventilationIntrauterine growth restrictionOligohydramniosGEIDIS is a national-based research-net registry of patients with bronchopulmonary dysplasia (BPD) from public and private Spanish hospitals. It was created to provide data on the clinical characterization and follow-up of infants with BPD until adulthood. The purpose of this observational study was to analyze the characteristics and the impact of perinatal risk factors on BPD severity. The study included 1755 preterm patients diagnosed with BPD. Of the total sample, 90.6% (n = 1591) were less than 30 weeks of gestation. The median gestational age was 27.1 weeks (25.8–28.5) and median birth weight 885 g (740–1,070 g). A total of 52.5% (n = 922) were classified as mild (type 1), 25.3% (n = 444) were moderate (type 2), and 22.2% (n = 389) were severe BPD (type 3). In patients born at under 30 weeks’ gestation, most pre-and postnatal risk factors for type 2/3 BPD were associated with the length of exposure to mechanical ventilation (MV). Independent prenatal risk factors were male gender, oligohydramnios, and intrauterine growth restriction. Postnatal risk factors included the need for FiO 2 of > 0.30 in the delivery room, nosocomial pneumonia, and the length of exposure to MV. Conclusion: In this national-based research-net registry of BPD patients, the length of MV is the most important risk factor associated with type 2/3 BPD. Among type 3 BPD patients, those who required an FiO2 > .30 at 36 weeks’ postmenstrual age had a higher morbidity, during hospitalization and at discharge, compared to those with nasal positive pressure but FiO2 < .30.SpringerFarmacología, Pediatría y Radiología2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/139520https://doi.org/10.1007/s00431-021-04248-zreponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésEuropean Journal of Pediatrics, 181 (2), 789-799.http://doi.org/10.1007/s00431-021-04248-zinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1395202026-06-17T12:51:07Z
dc.title.none.fl_str_mv Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
title Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
spellingShingle Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
Ramos-Navarro, Cristina
Bronchopulmonary dysplasia
GEIDIS network
Preterm infants
Mechanical ventilation
Intrauterine growth restriction
Oligohydramnios
title_short Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
title_full Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
title_fullStr Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
title_full_unstemmed Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
title_sort Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
dc.creator.none.fl_str_mv Ramos-Navarro, Cristina
Maderuelo-Rodríguez, Elena
Concheiro-Guisán, Ana
Pérez-Tarazona, Santiago
Rueda-Esteban, Santiago
Sánchez-Torres, Ana
Sánchez-Solís, Manuel
Sanz-López, Ester
Sánchez-Luna, Manuel
Andrés Martín, Anselmo
Delgado Pecellín, Isabel
author Ramos-Navarro, Cristina
author_facet Ramos-Navarro, Cristina
Maderuelo-Rodríguez, Elena
Concheiro-Guisán, Ana
Pérez-Tarazona, Santiago
Rueda-Esteban, Santiago
Sánchez-Torres, Ana
Sánchez-Solís, Manuel
Sanz-López, Ester
Sánchez-Luna, Manuel
Andrés Martín, Anselmo
Delgado Pecellín, Isabel
author_role author
author2 Maderuelo-Rodríguez, Elena
Concheiro-Guisán, Ana
Pérez-Tarazona, Santiago
Rueda-Esteban, Santiago
Sánchez-Torres, Ana
Sánchez-Solís, Manuel
Sanz-López, Ester
Sánchez-Luna, Manuel
Andrés Martín, Anselmo
Delgado Pecellín, Isabel
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Farmacología, Pediatría y Radiología
dc.subject.none.fl_str_mv Bronchopulmonary dysplasia
GEIDIS network
Preterm infants
Mechanical ventilation
Intrauterine growth restriction
Oligohydramnios
topic Bronchopulmonary dysplasia
GEIDIS network
Preterm infants
Mechanical ventilation
Intrauterine growth restriction
Oligohydramnios
description GEIDIS is a national-based research-net registry of patients with bronchopulmonary dysplasia (BPD) from public and private Spanish hospitals. It was created to provide data on the clinical characterization and follow-up of infants with BPD until adulthood. The purpose of this observational study was to analyze the characteristics and the impact of perinatal risk factors on BPD severity. The study included 1755 preterm patients diagnosed with BPD. Of the total sample, 90.6% (n = 1591) were less than 30 weeks of gestation. The median gestational age was 27.1 weeks (25.8–28.5) and median birth weight 885 g (740–1,070 g). A total of 52.5% (n = 922) were classified as mild (type 1), 25.3% (n = 444) were moderate (type 2), and 22.2% (n = 389) were severe BPD (type 3). In patients born at under 30 weeks’ gestation, most pre-and postnatal risk factors for type 2/3 BPD were associated with the length of exposure to mechanical ventilation (MV). Independent prenatal risk factors were male gender, oligohydramnios, and intrauterine growth restriction. Postnatal risk factors included the need for FiO 2 of > 0.30 in the delivery room, nosocomial pneumonia, and the length of exposure to MV. Conclusion: In this national-based research-net registry of BPD patients, the length of MV is the most important risk factor associated with type 2/3 BPD. Among type 3 BPD patients, those who required an FiO2 > .30 at 36 weeks’ postmenstrual age had a higher morbidity, during hospitalization and at discharge, compared to those with nasal positive pressure but FiO2 < .30.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/139520
https://doi.org/10.1007/s00431-021-04248-z
url https://hdl.handle.net/11441/139520
https://doi.org/10.1007/s00431-021-04248-z
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Journal of Pediatrics, 181 (2), 789-799.
http://doi.org/10.1007/s00431-021-04248-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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