miR-203 drives breast cancer cell differentiation

Breast cancer; Cell differentiation

Detalhes bibliográficos
Autores: Martínez-Illescas, Nuria G., Leal, Silvia, González, Patricia, Graña Castro, Osvaldo, Muñoz-Oliveira, Juan José, Cortés-Peña, Alfonso, Malumbres, Marcos
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10178
Acesso em linha:https://hdl.handle.net/11351/10178
http://hdl.handle.net/11351/10178
Access Level:acceso abierto
Palavra-chave:Mama - Càncer - Aspectes genètics
MicroARN
Cèl·lules canceroses
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
ANATOMY::Cells::Stem Cells::Neoplastic Stem Cells
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN
ANATOMÍA::células::células madre::células madre neoplásicas
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oai_identifier_str oai:recercat.cat:11351/10178
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv miR-203 drives breast cancer cell differentiation
title miR-203 drives breast cancer cell differentiation
spellingShingle miR-203 drives breast cancer cell differentiation
Martínez-Illescas, Nuria G.
Mama - Càncer - Aspectes genètics
MicroARN
Cèl·lules canceroses
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
ANATOMY::Cells::Stem Cells::Neoplastic Stem Cells
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN
ANATOMÍA::células::células madre::células madre neoplásicas
title_short miR-203 drives breast cancer cell differentiation
title_full miR-203 drives breast cancer cell differentiation
title_fullStr miR-203 drives breast cancer cell differentiation
title_full_unstemmed miR-203 drives breast cancer cell differentiation
title_sort miR-203 drives breast cancer cell differentiation
dc.creator.none.fl_str_mv Martínez-Illescas, Nuria G.
Leal, Silvia
González, Patricia
Graña Castro, Osvaldo
Muñoz-Oliveira, Juan José
Cortés-Peña, Alfonso
Malumbres, Marcos
author Martínez-Illescas, Nuria G.
author_facet Martínez-Illescas, Nuria G.
Leal, Silvia
González, Patricia
Graña Castro, Osvaldo
Muñoz-Oliveira, Juan José
Cortés-Peña, Alfonso
Malumbres, Marcos
author_role author
author2 Leal, Silvia
González, Patricia
Graña Castro, Osvaldo
Muñoz-Oliveira, Juan José
Cortés-Peña, Alfonso
Malumbres, Marcos
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Martínez-Illescas NG] Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain. Breast and Gynecologic Cancer Group, Research Institute i+12, Madrid, Spain. Cell Division and Cancer Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [Leal S] Molecular Imaging Unit, CNIO, Madrid, Spain. [González P] Histopathology Unit, CNIO, Madrid, Spain. [Graña-Castro O] Bioinformatics Unit, CNIO, Madrid, Spain. Department of Basic Medical Sciences, Institute of Applied Molecular Medicine (IMMA Nemesio Díez), San Pablo-CEU University, Madrid, Spain. [Muñoz-Oliveira JJ, Cortés-Peña A] Flow Cytometry and Fluorescence Microscopy Unit (CAI), Complutense University, Madrid, Spain. [Malumbres M] Cell Division and Cancer Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Cancer Cell Cycle Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. ICREA, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Mama - Càncer - Aspectes genètics
MicroARN
Cèl·lules canceroses
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
ANATOMY::Cells::Stem Cells::Neoplastic Stem Cells
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN
ANATOMÍA::células::células madre::células madre neoplásicas
topic Mama - Càncer - Aspectes genètics
MicroARN
Cèl·lules canceroses
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
ANATOMY::Cells::Stem Cells::Neoplastic Stem Cells
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN
ANATOMÍA::células::células madre::células madre neoplásicas
description Breast cancer; Cell differentiation
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10178
http://hdl.handle.net/11351/10178
url https://hdl.handle.net/11351/10178
http://hdl.handle.net/11351/10178
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Breast Cancer Research;25
https://doi.org/10.1186/s13058-023-01690-9
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418277560647680
spelling miR-203 drives breast cancer cell differentiationMartínez-Illescas, Nuria G.Leal, SilviaGonzález, PatriciaGraña Castro, OsvaldoMuñoz-Oliveira, Juan JoséCortés-Peña, AlfonsoMalumbres, MarcosMama - Càncer - Aspectes genèticsMicroARNCèl·lules cancerosesDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::Other subheadings::/geneticsCHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAsANATOMY::Cells::Stem Cells::Neoplastic Stem CellsENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::Otros calificadores::/genéticaCOMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARNANATOMÍA::células::células madre::células madre neoplásicasBreast cancer; Cell differentiationCáncer de mama; Diferenciación celularCàncer de mama; Diferenciació cel·lularA hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mouse in vivo approaches and both mouse and human-derived tridimensional organoid cultures, we report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells.This work has been in part financed by the crowdfunding project “Match point against breast cancer” (PRECIPITA PR242, 2019; FECYT; Spanish Ministry of Science and Innovation, MICINN, led by MS-R) and donations to Asociación Española contra el Cáncer (AECC). The work has been funded also by the Comunidad de Madrid (Y2020/BIO-6519 and S2022/BMD-7437) to MM, the Spanish Ministry of Science and Innovation through CNS2022-135364 to MS-R and PID2021-128726 to MM and the Spanish Ministry of Economy and Competitiveness by Instituto de Salud Carlos III (ISC III) through PI20/00590 to CS and co-funded by the European Union. MS-R was supported by AECC (AIOA120833SALA and INVES18005SALA), a Juan de la Cierva Incorporación and a Ramón y Cajal contract (RYC2020-028929-I, from the MICINN, FSE/ Agencia Estatal de Investigación). NGM-I was supported by AECC (PRDMA19003GARC).BMCInstitut Català de la Salut[Martínez-Illescas NG] Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain. Breast and Gynecologic Cancer Group, Research Institute i+12, Madrid, Spain. Cell Division and Cancer Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [Leal S] Molecular Imaging Unit, CNIO, Madrid, Spain. [González P] Histopathology Unit, CNIO, Madrid, Spain. [Graña-Castro O] Bioinformatics Unit, CNIO, Madrid, Spain. Department of Basic Medical Sciences, Institute of Applied Molecular Medicine (IMMA Nemesio Díez), San Pablo-CEU University, Madrid, Spain. [Muñoz-Oliveira JJ, Cortés-Peña A] Flow Cytometry and Fluorescence Microscopy Unit (CAI), Complutense University, Madrid, Spain. [Malumbres M] Cell Division and Cancer Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Cancer Cell Cycle Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. ICREA, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/10178http://hdl.handle.net/11351/10178Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBreast Cancer Research;25https://doi.org/10.1186/s13058-023-01690-9Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/101782026-05-29T05:05:01Z
score 15.812429

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