Supercritical fluid extraction of emulsions to nanoencapsulate vitamin E in polycaprolactone
Supercritical fluid extraction of emulsions (SFEE) was used to encapsulate a liquid lipophilic compound, concretely vitamin E in polycaprolactone. The influence of the initial formulation on the characteristics of the nanoparticles (encapsulation efficiency, particle size distribution, and morpholog...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/378952 |
| Acceso en línea: | http://hdl.handle.net/10261/378952 https://api.elsevier.com/content/abstract/scopus_id/84992695914 |
| Access Level: | acceso abierto |
| Palabra clave: | Encapsulation Nanocapsules Polycaprolactone Supercritical fluid extraction of emulsions Vitamin E |
| Sumario: | Supercritical fluid extraction of emulsions (SFEE) was used to encapsulate a liquid lipophilic compound, concretely vitamin E in polycaprolactone. The influence of the initial formulation on the characteristics of the nanoparticles (encapsulation efficiency, particle size distribution, and morphology) was studied. The obtained particles exhibited a high encapsulation efficiency (around 90%), narrow particle size distribution (polydispersity index between 0.24 and 0.54), and nanoscale particle sizes (between 8 and 276 nm). The morphological analysis indicated that the particles were spherical, with a core-shell structure, and non-aggregated. Operating at 8 MPa and 313 K, with a CO2 flow rate of 7.2 kg h−1 kg emulsion−1, a low residual concentration of organic solvent (50 ppm) was obtained in 240 min at a CO2 consumption of 101 kg CO2 kg acetone−1. Stability tests indicated that the capsules remained unchanged over long storage periods (6 and 12 months). |
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