Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity
Abstract: We report the synthesis and in vitro activity against T. cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 values lower than 1.5 M. Moreover, unspecific cytot...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/40413 |
| Acceso en línea: | https://hdl.handle.net/10171/40413 |
| Access Level: | acceso abierto |
| Palabra clave: | Chagas disease Trypanosoma cruzi Quinoxaline N-oxide Cytotoxicity Genotoxicity Materias Investigacion::Farmacia::Química farmacéutica Materias Investigacion::Farmacia::Farmacia y farmacología |
| Sumario: | Abstract: We report the synthesis and in vitro activity against T. cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 values lower than 1.5 M. Moreover, unspecific cytotoxicity and genotoxicity studies are also reported. Compound 14 showed a SI higher than 24, whereas compound 10 was the only one that was negative in the genotoxicity screening. |
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