Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry
Background: Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/180937 |
| Acceso en línea: | https://hdl.handle.net/11441/180937 https://doi.org/10.1016/j.arbres.2024.06.019 |
| Access Level: | acceso abierto |
| Palabra clave: | Alpha1-antitrypsin Alpha1-antitrypsin deficiency Chronic obstructive pulmonary disease Gender |
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Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registryErsöz, HilalTorres-Durán, MaríaTurner, Alice M.Tanash, HananGarcía, Carlota RodríguezCorsico, Angelo GuidoLópez-Campos Bodineau, José LuisTrudzinski, Franziska C.Alpha1-antitrypsinAlpha1-antitrypsin deficiencyChronic obstructive pulmonary diseaseGenderBackground: Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort study. Methods: Baseline data from PiZZ individuals, enrolled in the registry with complete data on sex and smoking history were analysed by group comparisons and binary logistic regression analyses. Results: 1283 patients with AATD, 49.3% women were analysed. Females reported less tobacco consumption (16.8±12.2 vs. 19.6±14.5 PY, p=0.006), occupational exposures towards gases, dusts or asbestos (p<0.005 each) and consumed less alcohol (5.5±7.6 vs. 8.4±10.3u/week, p<0.001). Females reported COPD (41% vs. 57%, p<0.001) and liver disease (11% vs. 20%, p<0.001) less often. However, they had a higher prevalence of bronchiectasis (24% vs. 13%, p<0.001). Despite better lung function (FEV1%pred. 73.6±29.9 vs. 62.7±29.5, p<0.001) females reported a similar symptom burden (CAT 13.4±9.5 vs. 12.5±8.9, p=ns) and exacerbation frequency (at least one in the previous year 30% vs. 26%, p=ns) compared to males. In multivariate analyses, female sex was an independent risk factor for exacerbations in the previous year OR 1.6 p=0.001 in addition to smoking history, COPD, asthma and bronchiectasis and was also identified as risk factors for symptom burden (CAT≥10) OR 1.4 p=0.014 besides age, BMI, COPD and smoking history. Conclusion: Men had higher rates of COPD and liver disease, women were more likely to have bronchiectasis. Women's higher symptom burden and exacerbation frequency suggest they may need tailored treatment approaches.Elsevier España SLU; Elsevier doyma SLMedicinaInstituto de Biomedicina de Sevilla (IBIS)2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/180937https://doi.org/10.1016/j.arbres.2024.06.019reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésArchivos de bronconeumologia, 61 (1), 22-30.https://www.sciencedirect.com/science/article/pii/S0300289624002448?via%3Dihubinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1809372026-06-17T12:51:07Z |
| dc.title.none.fl_str_mv |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| title |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| spellingShingle |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry Ersöz, Hilal Alpha1-antitrypsin Alpha1-antitrypsin deficiency Chronic obstructive pulmonary disease Gender |
| title_short |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| title_full |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| title_fullStr |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| title_full_unstemmed |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| title_sort |
Sex-differences in alpha-1 antitrypsin deficiency: data from the EARCO registry |
| dc.creator.none.fl_str_mv |
Ersöz, Hilal Torres-Durán, María Turner, Alice M. Tanash, Hanan García, Carlota Rodríguez Corsico, Angelo Guido López-Campos Bodineau, José Luis Trudzinski, Franziska C. |
| author |
Ersöz, Hilal |
| author_facet |
Ersöz, Hilal Torres-Durán, María Turner, Alice M. Tanash, Hanan García, Carlota Rodríguez Corsico, Angelo Guido López-Campos Bodineau, José Luis Trudzinski, Franziska C. |
| author_role |
author |
| author2 |
Torres-Durán, María Turner, Alice M. Tanash, Hanan García, Carlota Rodríguez Corsico, Angelo Guido López-Campos Bodineau, José Luis Trudzinski, Franziska C. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Medicina Instituto de Biomedicina de Sevilla (IBIS) |
| dc.subject.none.fl_str_mv |
Alpha1-antitrypsin Alpha1-antitrypsin deficiency Chronic obstructive pulmonary disease Gender |
| topic |
Alpha1-antitrypsin Alpha1-antitrypsin deficiency Chronic obstructive pulmonary disease Gender |
| description |
Background: Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort study. Methods: Baseline data from PiZZ individuals, enrolled in the registry with complete data on sex and smoking history were analysed by group comparisons and binary logistic regression analyses. Results: 1283 patients with AATD, 49.3% women were analysed. Females reported less tobacco consumption (16.8±12.2 vs. 19.6±14.5 PY, p=0.006), occupational exposures towards gases, dusts or asbestos (p<0.005 each) and consumed less alcohol (5.5±7.6 vs. 8.4±10.3u/week, p<0.001). Females reported COPD (41% vs. 57%, p<0.001) and liver disease (11% vs. 20%, p<0.001) less often. However, they had a higher prevalence of bronchiectasis (24% vs. 13%, p<0.001). Despite better lung function (FEV1%pred. 73.6±29.9 vs. 62.7±29.5, p<0.001) females reported a similar symptom burden (CAT 13.4±9.5 vs. 12.5±8.9, p=ns) and exacerbation frequency (at least one in the previous year 30% vs. 26%, p=ns) compared to males. In multivariate analyses, female sex was an independent risk factor for exacerbations in the previous year OR 1.6 p=0.001 in addition to smoking history, COPD, asthma and bronchiectasis and was also identified as risk factors for symptom burden (CAT≥10) OR 1.4 p=0.014 besides age, BMI, COPD and smoking history. Conclusion: Men had higher rates of COPD and liver disease, women were more likely to have bronchiectasis. Women's higher symptom burden and exacerbation frequency suggest they may need tailored treatment approaches. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11441/180937 https://doi.org/10.1016/j.arbres.2024.06.019 |
| url |
https://hdl.handle.net/11441/180937 https://doi.org/10.1016/j.arbres.2024.06.019 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Archivos de bronconeumologia, 61 (1), 22-30. https://www.sciencedirect.com/science/article/pii/S0300289624002448?via%3Dihub |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier España SLU; Elsevier doyma SL |
| publisher.none.fl_str_mv |
Elsevier España SLU; Elsevier doyma SL |
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reponame:idUS. Depósito de Investigación de la Universidad de Sevilla instname:Universidad de Sevilla (US) |
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Universidad de Sevilla (US) |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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