Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study

Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (heal...

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Autores: Agostinis-Sobrinho, César, Rosário, Rafaela, Izquierdo Redín, Mikel, García Hermoso, Antonio, Ramírez Vélez, Robinson
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/37671
Acceso en línea:https://hdl.handle.net/2454/37671
Access Level:acceso abierto
Palabra clave:Metabolic
Healthy
Obese
Aerobic
Fitness
Inflammation
Youth
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spelling Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort studyAgostinis-Sobrinho, CésarRosário, RafaelaIzquierdo Redín, MikelGarcía Hermoso, AntonioRamírez Vélez, RobinsonMetabolicHealthyObeseAerobicFitnessInflammationYouthResults from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12–18 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age-and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy nonoverweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders.The Research Centre on Physical Activity Health and Leisure (CIAFEL) is supported by UID/DTP/00617/2013 (FCT). R.S. has a Discovery Early Career Research Award from the Australian Research Council (DE150101921). The FUPRECOL Study was carried out with the financial support of Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología 'Francisco José de Caldas' COLCIENCIAS (Contract Nº 671-2014 Code 122265743978). This study was funded by the Department of Education (Grand number: CENEDUCA1/2019) of the Government of Navarra (Spain). A.G.-H. is a Miguel Servet Fellow (Instituto de Salud Carlos III—CP18/0150). R.R.-V. is funded in part by a Postdoctoral Fellowship Resolution ID 420/2019 of the Universidad Pública de Navarra.MDPICiencias de la SaludOsasun ZientziakGobierno de Navarra / Nafarroako Gobernua, CENEDUCA1/2019Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/37671reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/376712026-06-17T12:41:47Z
dc.title.none.fl_str_mv Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
title Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
spellingShingle Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
Agostinis-Sobrinho, César
Metabolic
Healthy
Obese
Aerobic
Fitness
Inflammation
Youth
title_short Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
title_full Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
title_fullStr Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
title_full_unstemmed Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
title_sort Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and C-reactive protein in adolescents—a multi-cohort study
dc.creator.none.fl_str_mv Agostinis-Sobrinho, César
Rosário, Rafaela
Izquierdo Redín, Mikel
García Hermoso, Antonio
Ramírez Vélez, Robinson
author Agostinis-Sobrinho, César
author_facet Agostinis-Sobrinho, César
Rosário, Rafaela
Izquierdo Redín, Mikel
García Hermoso, Antonio
Ramírez Vélez, Robinson
author_role author
author2 Rosário, Rafaela
Izquierdo Redín, Mikel
García Hermoso, Antonio
Ramírez Vélez, Robinson
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
Gobierno de Navarra / Nafarroako Gobernua, CENEDUCA1/2019
Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.subject.none.fl_str_mv Metabolic
Healthy
Obese
Aerobic
Fitness
Inflammation
Youth
topic Metabolic
Healthy
Obese
Aerobic
Fitness
Inflammation
Youth
description Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12–18 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age-and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy nonoverweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/37671
url https://hdl.handle.net/2454/37671
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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