Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2021 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/179843 |
| Acesso em linha: | https://hdl.handle.net/2445/179843 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Malaltia de Parkinson Parkinson's disease |
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Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-UpSantos García, DiegoDe Deus, TeresaCores, CarlosCanfield, HectorPaz González, JoseMartínez Miró, CristinaValdés Aymerich, LorenaSuárez, EsterJesús, SilviaAguilar, MiquelPastor, PauPlanellas, LluísCosgaya, MarinaGarcía Caldentey, JuanCaballol, NúriaLegarda, InesHernández-Vara, JorgeCabo, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, Maria AsunciónCatalán, MariaNogueira, VíctorPuente, VíctorDotor, JulioBorrué, CarmenSolano, BertaÁlvarez Sauco, MariaVela, LydiaEscalante, SoniaCubo, EstherCarrillo, FranciscoMartínez Castrillo, JuanSánchez Alonso, PilarAlonso, GemmaLópez Ariztegui, NuriaGastón, ItziarKulisevsky, JaimeBlázquez, MartaSeijo Martínez, ManuelRúiz Martínez, JavierValero, CaridadKurtis, MonicaFábregues, Oriol deArdura, JessicaAlonso, RubenOrdás, CarlosLópez Díaz, LuisMcafee, DarrianMartinez-Martin, PabloMir, PabloCoppadis Study GroupMalaltia de ParkinsonParkinson's diseaseBackground and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = -0.52), change from V0 to V2 in PDSS (Parkinson's Disease Sleep Scale) (β = -0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.MDPI AG2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/179843Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jpm11070626Journal of Personalized Medicine, 2021, vol. 11, issue. 7, p. 626-651https://doi.org/10.3390/jpm11070626cc by (c) Santos García, D. et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1798432026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| spellingShingle |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up Santos García, Diego Malaltia de Parkinson Parkinson's disease |
| title_short |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_full |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_fullStr |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_full_unstemmed |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_sort |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| dc.creator.none.fl_str_mv |
Santos García, Diego De Deus, Teresa Cores, Carlos Canfield, Hector Paz González, Jose Martínez Miró, Cristina Valdés Aymerich, Lorena Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández-Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, Maria Nogueira, Víctor Puente, Víctor Dotor, Julio Borrué, Carmen Solano, Berta Álvarez Sauco, Maria Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso, Gemma López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez, Marta Seijo Martínez, Manuel Rúiz Martínez, Javier Valero, Caridad Kurtis, Monica Fábregues, Oriol de Ardura, Jessica Alonso, Ruben Ordás, Carlos López Díaz, Luis Mcafee, Darrian Martinez-Martin, Pablo Mir, Pablo Coppadis Study Group |
| author |
Santos García, Diego |
| author_facet |
Santos García, Diego De Deus, Teresa Cores, Carlos Canfield, Hector Paz González, Jose Martínez Miró, Cristina Valdés Aymerich, Lorena Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández-Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, Maria Nogueira, Víctor Puente, Víctor Dotor, Julio Borrué, Carmen Solano, Berta Álvarez Sauco, Maria Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso, Gemma López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez, Marta Seijo Martínez, Manuel Rúiz Martínez, Javier Valero, Caridad Kurtis, Monica Fábregues, Oriol de Ardura, Jessica Alonso, Ruben Ordás, Carlos López Díaz, Luis Mcafee, Darrian Martinez-Martin, Pablo Mir, Pablo Coppadis Study Group |
| author_role |
author |
| author2 |
De Deus, Teresa Cores, Carlos Canfield, Hector Paz González, Jose Martínez Miró, Cristina Valdés Aymerich, Lorena Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández-Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, Maria Nogueira, Víctor Puente, Víctor Dotor, Julio Borrué, Carmen Solano, Berta Álvarez Sauco, Maria Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso, Gemma López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez, Marta Seijo Martínez, Manuel Rúiz Martínez, Javier Valero, Caridad Kurtis, Monica Fábregues, Oriol de Ardura, Jessica Alonso, Ruben Ordás, Carlos López Díaz, Luis Mcafee, Darrian Martinez-Martin, Pablo Mir, Pablo Coppadis Study Group |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Malaltia de Parkinson Parkinson's disease |
| topic |
Malaltia de Parkinson Parkinson's disease |
| description |
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = -0.52), change from V0 to V2 in PDSS (Parkinson's Disease Sleep Scale) (β = -0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/179843 |
| url |
https://hdl.handle.net/2445/179843 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3390/jpm11070626 Journal of Personalized Medicine, 2021, vol. 11, issue. 7, p. 626-651 https://doi.org/10.3390/jpm11070626 |
| dc.rights.none.fl_str_mv |
cc by (c) Santos García, D. et al, 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by (c) Santos García, D. et al, 2021 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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MDPI AG |
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MDPI AG |
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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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