Intraabdominal candidiasis
The clinical criteria for defining intraabdominal candidiasis (IAC) are not specific, although a recent European consensus of experts shortened the definition of an IAC episode [10]. Inter-national guidelines focus mostly on candidemia and make little reference to antifungal therapy for IAC [11,12]....
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:187212 |
| Acceso en línea: | https://ddd.uab.cat/record/187212 |
| Access Level: | acceso abierto |
| Palabra clave: | Candidiasi Septicèmia |
| Sumario: | The clinical criteria for defining intraabdominal candidiasis (IAC) are not specific, although a recent European consensus of experts shortened the definition of an IAC episode [10]. Inter-national guidelines focus mostly on candidemia and make little reference to antifungal therapy for IAC [11,12]. Patients in the intensive care unit (ICU) are at the highest risk for invasive candidiasis, mostly due to the severity of their disease immune-suppressive states, pro-longed length of stay, septic shock and Candidacolonization. Colonization occurs in the ICU population during the first week in up to 80% of cases [7,13], but few develop an ensuing se-vere infection [14]. The pathophysiology route of infection will determine the clinical scenario [15]; indeed, during a large recent study [9] focusing on intra-abdominal candidiasis, only 14% patients also developed candidemiaDelay in the initiation of treatment for invasive candidiasis has been associated with increased mortality [16-18]. It remains unclear which patients should receive empirical treatment or which not. According to current guidelines, appropriate treatment is based on azoles, poly-enes or echinocandins; however, the differences between these groups according to thetreatment of IAC have not been assessed, neither the differences between those more severe than those in regular wards. |
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