Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior

Ti prosthesis have shown better biological compatibility, mechanical performance, and resistance to corrosion in cases of bone replacements. Nevertheless, fully dense Ti in connection with bone-host tissues show stress-shielding phenomenon that, together with the development of frequent undesirable...

ver descrição completa

Detalhes bibliográficos
Autores: Gaviria, Juliana, Alcudia Cruz, Ana, Begines Ruiz, Belén, Beltrán, Ana M., Rodríguez-Ortiz, José Antonio, Trueba Muñoz, Paloma, Villarraga, Junes, Torres Hernández, Yadir
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/108031
Acesso em linha:https://hdl.handle.net/11441/108031
https://doi.org/10.3390/met11050692
Access Level:acceso abierto
Palavra-chave:Porous titanium
Silver nanoparticles
Biofunctionalized titanium
Antibacterial properties
id ES_bdebe5b5114f4e8291fa3fc0d1f45b05
oai_identifier_str oai:idus.us.es:11441/108031
network_acronym_str ES
network_name_str España
repository_id_str
spelling Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial BehaviorGaviria, JulianaAlcudia Cruz, AnaBegines Ruiz, BelénBeltrán, Ana M.Rodríguez-Ortiz, José AntonioTrueba Muñoz, PalomaVillarraga, JunesTorres Hernández, YadirPorous titaniumSilver nanoparticlesBiofunctionalized titaniumAntibacterial propertiesTi prosthesis have shown better biological compatibility, mechanical performance, and resistance to corrosion in cases of bone replacements. Nevertheless, fully dense Ti in connection with bone-host tissues show stress-shielding phenomenon that, together with the development of frequent undesirable microbial infections, may lead to implant failures. To overcome these issues, the present study aimed at the development of a novel combination of a chemically functionalized porous Ti substrate with a potentially therapeutic AgNPs coating. Fully dense and porous Ti substrates (30 and 60 vol.%, 100–200 and 355–500 μm, as spacer particles) were studied. Ti surface was treated with acid or basic medium followed by silanization and deposition of AgNPs by “submerged” and “in situ” methods. In general, for similar porosity, mechanical resistance decreased as pore size increased. Acidic reagent and submerged methodology were the best combination for fully dense Ti substrates. Hence, they were also employed for porous Ti substrates. Depending on the porosity of the substrates, variations can be observed both in the size and degree of agglomeration of the deposited AgNPs, entailing differences in the antibacterial behavior of the samples.Ministry of Science and Innovation of Spain PID2019-109371GB-I00Junta de Andalucía– FEDER (Spain) US-1259771Junta de Andalucía-Proyecto de Excelencia (Spain) P18-FR-2038MDPIQuímica Orgánica y FarmacéuticaIngeniería y Ciencia de los Materiales y del TransporteFQM135: Carbohidratos y PolímerosTEP123: Metalurgia e Ingeniería de los Materiales2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/108031https://doi.org/10.3390/met11050692reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMetals, 11 (5), 692-.PID2019-109371GB-I00US-1259771P18-FR-2038https://www.mdpi.com/2075-4701/11/5/692info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1080312026-06-17T12:51:07Z
dc.title.none.fl_str_mv Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
title Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
spellingShingle Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
Gaviria, Juliana
Porous titanium
Silver nanoparticles
Biofunctionalized titanium
Antibacterial properties
title_short Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
title_full Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
title_fullStr Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
title_full_unstemmed Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
title_sort Biofunctionalization of Porous Ti Substrates Coated with Ag Nanoparticles for Potential Antibacterial Behavior
dc.creator.none.fl_str_mv Gaviria, Juliana
Alcudia Cruz, Ana
Begines Ruiz, Belén
Beltrán, Ana M.
Rodríguez-Ortiz, José Antonio
Trueba Muñoz, Paloma
Villarraga, Junes
Torres Hernández, Yadir
author Gaviria, Juliana
author_facet Gaviria, Juliana
Alcudia Cruz, Ana
Begines Ruiz, Belén
Beltrán, Ana M.
Rodríguez-Ortiz, José Antonio
Trueba Muñoz, Paloma
Villarraga, Junes
Torres Hernández, Yadir
author_role author
author2 Alcudia Cruz, Ana
Begines Ruiz, Belén
Beltrán, Ana M.
Rodríguez-Ortiz, José Antonio
Trueba Muñoz, Paloma
Villarraga, Junes
Torres Hernández, Yadir
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Química Orgánica y Farmacéutica
Ingeniería y Ciencia de los Materiales y del Transporte
FQM135: Carbohidratos y Polímeros
TEP123: Metalurgia e Ingeniería de los Materiales
dc.subject.none.fl_str_mv Porous titanium
Silver nanoparticles
Biofunctionalized titanium
Antibacterial properties
topic Porous titanium
Silver nanoparticles
Biofunctionalized titanium
Antibacterial properties
description Ti prosthesis have shown better biological compatibility, mechanical performance, and resistance to corrosion in cases of bone replacements. Nevertheless, fully dense Ti in connection with bone-host tissues show stress-shielding phenomenon that, together with the development of frequent undesirable microbial infections, may lead to implant failures. To overcome these issues, the present study aimed at the development of a novel combination of a chemically functionalized porous Ti substrate with a potentially therapeutic AgNPs coating. Fully dense and porous Ti substrates (30 and 60 vol.%, 100–200 and 355–500 μm, as spacer particles) were studied. Ti surface was treated with acid or basic medium followed by silanization and deposition of AgNPs by “submerged” and “in situ” methods. In general, for similar porosity, mechanical resistance decreased as pore size increased. Acidic reagent and submerged methodology were the best combination for fully dense Ti substrates. Hence, they were also employed for porous Ti substrates. Depending on the porosity of the substrates, variations can be observed both in the size and degree of agglomeration of the deposited AgNPs, entailing differences in the antibacterial behavior of the samples.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/108031
https://doi.org/10.3390/met11050692
url https://hdl.handle.net/11441/108031
https://doi.org/10.3390/met11050692
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Metals, 11 (5), 692-.
PID2019-109371GB-I00
US-1259771
P18-FR-2038
https://www.mdpi.com/2075-4701/11/5/692
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418241898577920
score 15,300724

Registos relacionados