Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration

The production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation of cus-tomised medications in small batches. This is particularly helpful for patients who need specific doses or for-mulations, such as children. Compounding pharmacies seek alternatives to convent...

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Autores: Rouaz El Hajoui, Khadija, Herrada Manchón, Helena, Rodríguez González, David, Fernández, Manuel Alejandro, Aguilar, Enrique, Suñé Pou, Marc, Nardi Ricart, Anna, Pérez Lozano, Pilar, García Montoya, Encarna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/201896
Acceso en línea:https://hdl.handle.net/2445/201896
Access Level:acceso abierto
Palabra clave:Posologia
Pediatria
Impressió 3D
Posology
Pediatrics
Three-dimensional printing
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spelling Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administrationRouaz El Hajoui, KhadijaHerrada Manchón, HelenaRodríguez González, DavidFernández, Manuel AlejandroAguilar, EnriqueSuñé Pou, MarcNardi Ricart, AnnaPérez Lozano, PilarGarcía Montoya, EncarnaPosologiaPediatriaImpressió 3DPosologyPediatricsThree-dimensional printingThe production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation of cus-tomised medications in small batches. This is particularly helpful for patients who need specific doses or for-mulations, such as children. Compounding pharmacies seek alternatives to conventional solid oral doses, opting for oral liquid formulations. However, ensuring quality and stability, especially for pH-sensitive APIs like omeprazole, remains a challenge. This paper presents the application of semi-solid extrusion 3D printing tech-nology to develop patient-tailored medicinal gummies, with an eye-catching appearances, serving as an inno-vative omeprazole pharmaceutical form for paediatric use. The study compares 3D printing hydrogels with dissolved omeprazole to hydrogels loaded with gastro-resistant omeprazole pellets, a ground-breaking approach.. Gastro-resistance and dissolution profiles were studied using different methods for better comparison and to emphasize the significance of the assay's methodology. Both developed formulas exhibit proper rheology, good printability, and meet content and mass uniformity standards. However, the high gastro-resistance and suitable release profile of 3D printed chewable semi-solid doses with enteric pellets highlight this as an effective strategy to address the challenge of paediatric medication.Elsevier BV2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/201896Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2023.123289International Journal of Pharmaceutics, 2023, vol. 643, p. 123289https://doi.org/10.1016/j.ijpharm.2023.123289cc by-nc-nd (c) Rouaz-El Hajoui, Khadija et al., 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2018962026-05-27T06:46:51Z
dc.title.none.fl_str_mv Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
title Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
spellingShingle Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
Rouaz El Hajoui, Khadija
Posologia
Pediatria
Impressió 3D
Posology
Pediatrics
Three-dimensional printing
title_short Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
title_full Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
title_fullStr Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
title_full_unstemmed Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
title_sort Pellets and gummies: seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration
dc.creator.none.fl_str_mv Rouaz El Hajoui, Khadija
Herrada Manchón, Helena
Rodríguez González, David
Fernández, Manuel Alejandro
Aguilar, Enrique
Suñé Pou, Marc
Nardi Ricart, Anna
Pérez Lozano, Pilar
García Montoya, Encarna
author Rouaz El Hajoui, Khadija
author_facet Rouaz El Hajoui, Khadija
Herrada Manchón, Helena
Rodríguez González, David
Fernández, Manuel Alejandro
Aguilar, Enrique
Suñé Pou, Marc
Nardi Ricart, Anna
Pérez Lozano, Pilar
García Montoya, Encarna
author_role author
author2 Herrada Manchón, Helena
Rodríguez González, David
Fernández, Manuel Alejandro
Aguilar, Enrique
Suñé Pou, Marc
Nardi Ricart, Anna
Pérez Lozano, Pilar
García Montoya, Encarna
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Posologia
Pediatria
Impressió 3D
Posology
Pediatrics
Three-dimensional printing
topic Posologia
Pediatria
Impressió 3D
Posology
Pediatrics
Three-dimensional printing
description The production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation of cus-tomised medications in small batches. This is particularly helpful for patients who need specific doses or for-mulations, such as children. Compounding pharmacies seek alternatives to conventional solid oral doses, opting for oral liquid formulations. However, ensuring quality and stability, especially for pH-sensitive APIs like omeprazole, remains a challenge. This paper presents the application of semi-solid extrusion 3D printing tech-nology to develop patient-tailored medicinal gummies, with an eye-catching appearances, serving as an inno-vative omeprazole pharmaceutical form for paediatric use. The study compares 3D printing hydrogels with dissolved omeprazole to hydrogels loaded with gastro-resistant omeprazole pellets, a ground-breaking approach.. Gastro-resistance and dissolution profiles were studied using different methods for better comparison and to emphasize the significance of the assay's methodology. Both developed formulas exhibit proper rheology, good printability, and meet content and mass uniformity standards. However, the high gastro-resistance and suitable release profile of 3D printed chewable semi-solid doses with enteric pellets highlight this as an effective strategy to address the challenge of paediatric medication.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/201896
url https://hdl.handle.net/2445/201896
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ijpharm.2023.123289
International Journal of Pharmaceutics, 2023, vol. 643, p. 123289
https://doi.org/10.1016/j.ijpharm.2023.123289
dc.rights.none.fl_str_mv cc by-nc-nd (c) Rouaz-El Hajoui, Khadija et al., 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Rouaz-El Hajoui, Khadija et al., 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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